TITLE

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

AUTHOR(S)
Bakker, Wineke; Eringa, Etto C,; Sipkema, Pieter; van Hinsbergh, Victor W. M.
PUB. DATE
December 2008
SOURCE
Cell & Tissue Research;Dec2008, Vol. 335 Issue 1, p165
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Endothelial dysfunction comprises a number of functional alterations in the vascular endothelium that are associated with diabetes and cardiovascular disease, including changes in vasoregulation, enhanced generation of reactive oxygen intermediates, inflammatory activation, and altered barrier function. Hyperglycemia is a characteristic feature of type 1 and type 2 diabetes and plays a pivotal role in diabetes-associated microvascular complications. Although hyperglycemia also contributes to the occurrence and progression of macrovascular disease (the major cause of death in type 2 diabetes), other factors such as dyslipidemia, hyperinsulinemia, and adipose-tissue-derived factors play a more dominant role. A mutual interaction between these factors and endothelial dysfunction occurs during the progression of the disease. We pay special attention to the possible involvement of endoplasmic reticulum stress (ER stress) and the role of obesity and adipose-derived adipokines as contributors to endothelial dysfunction in type 2 diabetes. The close interaction of adipocytes of perivascular adipose tissue with arteries and arterioles facilitates the exposure of their endothelial cells to adipokines, particularly if inflammation activates the adipose tissue and thus affects vasoregulation and capillary recruitment in skeletal muscle. Hence, an initial dysfunction of endothelial cells underlies metabolic and vascular alterations that contribute to the development of type 2 diabetes.
ACCESSION #
35622890

 

Related Articles

  • Third Annual World Congress on the Insulin Resistance Syndrome. Bloomgarden, Zachary T. // Diabetes Care;Aug2006, Vol. 29 Issue 8, p1973 

    The article highlights the 3rd Annual World Congress on the Insulin Resistance Syndrome held from November 17 to 19, 2005 in San Francisco, California. Peter Grant, of Leeds, England, discussed the role of insulin signaling pathways in acute coronary syndrome, pointing out that type 2 diabetes...

  • Metabolic Syndrome Model Definitions Predicting Type 2 Diabetes and Cardiovascular Disease. POVEL, CÉCILE M.; BEULENS, JOLINE W.; VAN DER SCHOUW, YVONNE T.; DOLLÉ, MARTIJN E. T.; SPIJKERMAN, NEMIEKE M. W.; VERSCHUREN, W. M. MONIQUE; FESKENS, EDITH J. M.; BOER, JOLANDA M. A. // Diabetes Care;Feb2013, Vol. 36 Issue 2, p362 

    OBJECTIVE--Metabolic syndrome (MetS) is a cluster of abdominal obesity, hyperglycemia, hypertension, and dyslipidemia, which increases the risk for type 2 diabetes and cardiovascular diseases (CVDs). Some argue that MetS is not a single disorder because the traditional MetS features do not...

  • Similarity of the Impact of Type 1 and Type 2 Diabetes on Cardiovascular Mortality in Middle-Aged Subjects. Juutilainen, Auni; Lehto, Seppo; Rönnemaa, Tapani; Pyörälä, Kalevi; Laakso, Markku // Diabetes Care;Apr2008, Vol. 31 Issue 4, p714 

    OBJECTIVE -- To compare the risk of cardiovascular disease (CVD) death and the impact of hyperglycemia on the risk of CVD mortality associated with type 1 diabetes to that associated with type 2 diabetes. RESEARCH DESIGN AND METHODS -- The study comprised 173 participants with type 1 diabetes,...

  • Postprandial Hyperglycemia and Cardiovascular Disease. Ceriello, Antonio // Diabetes Care;Mar2009, Vol. 32 Issue 3, p521 

    The author discusses whether the Hyperglycemia and its Effect After Acute Myocardial Infarction on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus (HEART2D) study can resolve the debate about the association of postprandial hyperglycemia with cardiovascular disease. He notes...

  • The Relationship of Cardiovascular Disease to Hyperglycemia. Ostrander Jr., Leon D.; Francis Jr., Thomas; Hayner, Norman S.; Kjelsberg, Marcus O.; Epstein, Frederick H. // Annals of Internal Medicine;Jun65, Vol. 62 Issue 6, p1188 

    Discusses studies on the relationship of cardiovascular disease to hyperglycemia. Percentage of diabetics who died of cardiovascular disease in 1957; Prevalence and severity of coronary atherosclerosis among hospitalized diabetics; Association between vascular disease and abnormalities of...

  • Insulin-Sensitizing Antihyperglycemic Drugs and Mortality After Acute Myocardial Infarction. Inzucchi, Silvio E.; Masoudi, Frederick A.; Wang, Yongfei; Kosiborod, Mikhail; Foody, Joanne M.; Setaro, John F.; Havranek, Edward P.; Krumholz, Harlan M. // Diabetes Care;Jul2005, Vol. 28 Issue 7, p1680 

    OBJECTIVE -- Thiazolidinediones (TZDs) and metformin are insulin-sensitizing antihyperglycemic agents with reported benefits on atherosclerosis. Despite extensive use in patients with diabetes and cardiovascular disease, there is a paucity of outcomes data with metformin and none yet with TZDs....

  • Reducing cardiovascular risk in patients with diabetes. Pasternak, Richard; Snow, Vincenza // Patient Care for the Nurse Practitioner;Sep2003, Vol. 6 Issue 9, p4 

    The article discusses the reduction of cardiovascular risk in patients with diabetes. Preventive treatment requires lifestyle modification and medication in a multifactorial intervention aimed at normalization of lipid levels and blood pressure, optimal treatment of hyperglycemia and insulin...

  • THE STUDY OF PROTHROBOTIC STATE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CARDIOVASCULAR DISEASES. Bădulescu, Oana; Bădescu, Codruţa; Ciocoiu, Manuela; Bădescu, Magda // Annals of the Romanian Society for Cell Biology;2011, Vol. 16 Issue 1, p81 

    Epidemiologic studies consider vascular complications as the first cause of death in diabetic patients. Persistent hyperglycemia is responsible for the affection of large vessels, causing severe diseases, such as myocardial infarction, cerebrovascular accident or diabetic gangrene. The objective...

  • Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals. Major-Pedersen, A.; Ihlemann, N.; Hermann, T. S.; Christiansen, B.; Dominguez, H.; Kveiborg, B.; Nielsen, D. B.; Svendsen, O. L.; Kø, L.; Torp-Pedersen, C. // Experimental Diabetes Research;2009, Special section p1 

    Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics