TITLE

Clustering of risk factors, metabolic syndrome, and coronary heart disease risk in hypertensive patients

PUB. DATE
December 2005
SOURCE
Asia Pacific Journal of Clinical Nutrition;2005 Supplement, Vol. 14, pS44
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background -- Hypertension and cardiovascular risk factors increase the risk of developing coronary heart disease. This study investigates the risk factors and metabolic syndrome present in hypertensive individuals. Objective -- To determine the common clustering of risk factors, prevalence of metabolic syndrome, and coronary heart disease risk among hypertensive individuals Design -- This is a descriptive cross-sectional pilot study done in Internal Medicine and Cardiology clinics of UP-Philippine General Hospital. Adult hypertensive patients and household members were recruited and screened for hypertension, diabetes, dyslipidemia, obesity, smoking, sedentarism, and metabolic syndrome (MetS: based on NCEP III criteria with IAS modification for Asians). Outcomes included proportion of individuals with combination of risk factors, prevalence of metabolic syndrome, and estimated coronary heart disease (CHD) risks using the Framingham risk prediction algorithm. Outcomes -- A total of 134 hypertensive individuals (100 patients and 34 household members) were included (age 5611 years, BMI 25.14.4 kg/m²). Dyslipidemia was most prevalent risk factor followed by sedentarism, obesity, diabetes, and active smoking. Reduced HDL level was most common form of dyslipidemia. In hypertensive patients, having at least three risk factors was most common. Hypertension and dyslipidemia plus one other risk factor was most frequently encountered. Hypertension, dyslipidemia, and sedentarism were the most common clustering. The prevalence of MetS was 66%. Among hypertensive patients with MetS, the average estimated CHD risk in the next 10 years is 18% and at least half are at high risk for CHD events. Among those without MetS, the average CHD risk is 10% and majority (73%) are at low risk. Conclusions -- Hypertensive individuals can have multiple risk factors and metabolic syndrome. Those with metabolic syndrome are at high risk to have CHD events in the next 10 years, similar to CHD risk equivalents. Emphasis should be given on early identification, intervention, and prevention of coronary heart disease in hypertensive individuals, especially those with metabolic syndrome.
ACCESSION #
35601749

 

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