TITLE

Radio-Adaptive Response to Environmental Exposures at Chernobyl

AUTHOR(S)
Rodgers, Brenda E.; Holmes, Kristen M.
PUB. DATE
April 2008
SOURCE
Dose-Response;2008, Vol. 6 Issue 2, p209
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The genetic consequences resulting from environmental exposure to ionizing radiation have a significant impact on both radiation regulatory policies and the comprehension of the human health risks associated with radiation exposure. The primary objectives of the study were to assess 1) genotoxicity of exposure to radiation as a function of absorbed dose and dose rate, and 2) induction of a radio-adaptive response following a priming dose at varying dose rates. Results demonstrated that sub-acute environmental exposures of 10cGy gamma radiation resulted in indistinguishable levels of chromosomal damage as compared to controls. A radio-adaptive response was observed in all experimental groups, exposed to a subsequent acute challenge dose of 1.5 Gy, demonstrating that low dose rates of low energy transfer (LET) radiation are effective in reducing genetic damage from a subsequent acute low-LET radiation exposure. Furthermore, the data presented herein demonstrate a potential beneficial effect of sub-chronic exposure to low levels of low-LET radiation in an environmental setting and do not support the Linear No Threshold (LNT) hypothesis.
ACCESSION #
35560589

 

Related Articles

  • THYROID CANCER AND THE CHORNOBYL ACCIDENT IN UKRAINE: EXPERIENCE WITH THE IMPLEMENTATION OF A FOLLOW-UP PROGRAMME. Bazyka, Dimitry A.; Prysyazhnyuk, Anatoly Ye.; Fuzik, Mykola M.; Fedorenko, Zoya P. // Radiation Protection Dosimetry;Sep2016, Vol. 171 Issue 1, p32 

    Thyroid cancer incidence, its annual variation pattern and influence of gender and age at exposure were analyzed in population groups of Ukraine exposed to ionizing radiation by the Chornobyl accident. Significant radiation risks are demonstrated in the recovery operation workers and evacuees...

  • GENETIC POLYMORPHISM OF 12S rRNA GENE AMONG DERMACENTOR RETICULATUS FABRICIUS TICKS IN THE CHERNOBYL NUCLEAR POWER PLANT EXCLUSION ZONE. Movila, Alexandru; Morozov, Alexandr; Sitnicov, Natalia // Journal of Parasitology;Feb2013, Vol. 99 Issue 1, p40 

    The molecular genetic variability of the 12S rRNA gene, on the basis of partial primary sequence and in silico-redicted secondary structures among Dermacentor reticulatus (Fabricius 1794) ticks, was studied in the Chernobyl Nuclear Power Plant (ChNPP) Exclusion Zone. In total, 20, 20, and 25...

  • DETERMINISTIC EFFECT OF LENS AT LEUKERGY OF PATIENTS WHO RECEIVED LOW DOSES OF IONISING RADIATION. Yeltokova, M.; Zharliganova, D.; Shaidarov, M.; Bakhtin, M.; Kazymbet, P.; Tel, L.; Dossakhanov, A.; Kozhakbayeva, M.; Hoshi, M. // Radiation Protection Dosimetry;2015 Special Isuue, Vol. 166, p324 

    To explore the possibility to use the lens extract as an in vitro stimulator to conduct a test of stimulated leukergy in liquidators of the accident consequences (LAC) on Chernobyl Nuclear Power Plant (CNPP) with a cataract in the long-term period. The study sample included 72 men--LAC on CNPP,...

  • A Review: Development of a Microdose Model for Analysis of Adaptive Response and Bystander Dose Response Behavior. Leonard, Bobby E. // Dose-Response;2008, Vol. 6 Issue 2, p113 

    Prior work has provided incremental phases to a microdosimetry modeling program to describe the dose response behavior of the radio-protective adaptive response effect. We have here consolidated these prior works (Leonard 2000, 2005, 2007a, 2007b, 2007c) to provide a composite, comprehensive...

  • Chernobyl reactor shut down amid uncertainty.  // Modern Power Systems;Jan97, Vol. 17 Issue 1, p10 

    Reports on Ukraine's shutdown of one of the nuclear reactors at the Chernobyl nuclear power plant. Plans to restart another unit at the power station; Agreement to close the Chernobyl site in 2000 due to pressure from the West.

  • Safe demise is finally planned for Ukraine's Chernobyl plant.  // ENR: Engineering News-Record;11/25/96, Vol. 237 Issue 22, p17 

    Reports that international funds have been committed to close the Chernobyl nuclear plant in Ukraine. Pledges by the Nuclear Safety Account and the European Union; Engineering projects at the plant.

  • Paying Chernobyl to go away. Greek, Dinah // Professional Engineering;09/03/97, Vol. 10 Issue 16, p16 

    Reports on financial issues involved in international efforts to completely shut down the Chernobyl nuclear power station in Ukraine. Agreement among G7 countries to launch the Shelter Implementation Program to stabilize the containment structure put over the power station's number four...

  • The shutdown question. A.R.S. // Bulletin of the Atomic Scientists;May/Jun1996, Vol. 52 Issue 3, p36 

    Discusses the possible consequences of the proposed closing of the Chernobyl Nuclear Power Station in Chornobyl, Ukraine. Power supply problems in Ukraine; Need to operate the power plant to provide all residents with sufficient power; Status of other energy plants in Ukraine.

  • Chernobyl to close by the year 2,000.  // UNESCO Courier;Sep95, Vol. 48 Issue 9, p46 

    Reports that Chernobyl's reactors will be closed by the end of the century. Assistance of other nations to maintain the steel and concrete protective shell surrounding the reactor that leaked; Management of radioactive waste.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics