- Toxicological Defense Mechanisms and the Shape of Dose-Response Relationships. Calabrese, Edward J. // Environmental Health Perspectives Supplements;Feb98 Supplement 1, Vol. 106, p273
Introduces a series of articles on the dose-response relationship, hazard assessment toxicology studies, and molecular and cellular defense mechanisms.
- Dear Synergy... Cassidy, Mark; Higgins, Robert // Synergy: Imaging & Therapy Practice;Sep2011, p30
A letter to the editor, along with its reply, is presented in response to an article by Robert Higgins on the RITE Project, that was published in one of the previous issues.
- The impact of compliance in pharmacokinetic studies. Vrijens, B.; Goetghebeur, E. // Statistical Methods in Medical Research;1999, Vol. 8 Issue 3, p247
In population pharmacokinetic (PK) studies, one observes just a few concentration measures spread out in time, on a sizable sample of the target population. Common-sense dictates that for estimation of a drug exposure--plasma concentration relationship, one needs accurate information on drug...
- Estimation of toxicity of chemical mixtures through modeling of chemical interactions. Mumtaz, M.M.; De Rosa, C.T.; Groten, J.; Feron, V.J.; Hansen, H.; Durkin, P.R. // Environmental Health Perspectives Supplements;Dec98 Supplement 6, Vol. 106, p1353
Focuses on the estimation of toxicity of low-level exposure to chemical mixtures through modeling of chemical interactions. Use of individual chemical dose-response assessments; Estimation of overall toxicities of the mixtures using the weight-of-evidence algorithm for the mixture.
- A nonlinear isobologram model with Box-Cox transformation to both sides for chemical mixtures. Chen, Ding G.; Pounds, Joel G. // Environmental Health Perspectives Supplements;Dec98 Supplement 6, Vol. 106, p1367
Presents a nonlinear isobologram model to analyze the joint action of chemical mixtures for quantitative dose-response relationships. Incorporation of additional two parameters to the model; Introduction of Box-Cox transformation; Application of the model to describe the toxicity of citrinin...
- Dose-response curve and plot symbols. // Environmental Health Perspectives Supplements;Aug99 Supplement 4, Vol. 107, p593
Presents a chart on definitions of symbols used in dose-response curve and plot of experiments in carcinogenesis. Includes symbols of consistent with linearity; Significant departure from linearity, upward curvature; Significant departure from linearity, downward curvature.
- Quantitative mechanistically based dose-response modeling with endocrine-active compounds. Andersen; Conolly, Melvin E. // Environmental Health Perspectives Supplements;Aug99 Supplement 4, Vol. 107, p631
Presents a method for testing toxicity of endocrine-active compounds on human health. Use of a quantitative mechanistically based dose-response (MBDR) model; Description and application of MBDR in risk assessments; Requirements for acceleration of model development and acceptance.
- Comments on papers by Andersen and Conolly and by Downs and Frankowski. Bogen, K.T. // Human & Experimental Toxicology;1998, Vol. 17 Issue 12, p711
Comments on studies which described a mechanistic cancer model fit to U-shaped dose-response data on enzymatically altered hepatocellular foci in rats. Prediction of a U-shaped dose-response relation; Discussion on a dose-response function involving a linear ratio modelling competing saturable...
- Introduction to BELLE Newsletter: Special issue on Chemical carcinogenesis epigenetic mechanisms and dose response. Calabrese, E. // Human & Experimental Toxicology;Oct2000, Vol. 19 Issue 10, p541
Introduces a series of articles on the assessment of epigenetic carcinogens and the shape of the dose-response curve.