A liquid waveguide based evanescent wave sensor integrated onto a microfluidic chip

Li, X. C.; Wu, J.; Liu, A. Q.; Li, Z. G.; Soew, Y. C.; Huang, H. J.; Xu, K.; Lin, J. T.
November 2008
Applied Physics Letters;11/10/2008, Vol. 93 Issue 19, p193901
Academic Journal
An evanescent wave sensor based on liquid waveguide is integrated onto a microfluidic chip. The structure of the liquid waveguide consists of three streams with two low refractive index fluids as cladding layers, which envelop a high refractive index fluid as a core layer along a microchannel. Light is coupled into the core layer, and a detected sample is injected into one cladding layer. The profile of the output light modal power is changed by varying the concentration of the sample. The sensor with a sensitivity of 275 μm2 l/mol can be used for real-time, low-cost, and label-free measurements in a wide range of applications.


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