Separation enhancement in pinched flow fractionation

Vig, Asger Laurberg; Kristensen, Anders
November 2008
Applied Physics Letters;11/17/2008, Vol. 93 Issue 20, p203507
Academic Journal
A method for enhancing the separation in the microfluidic size separation technique called pinched flow fractionation (PFF) is demonstrated experimentally and analyzed by numerical calculations. The enhancement is caused by a geometrical modification of the original PFF design. Seven different polystyrene bead sizes ranging from 0.25 to 2.5 μm in radius were separated in a PFF and in an enhanced PFF device. The separation in the two types of devices were compared and an amplification in the separation of up to 70% was achieved. Numerical calculations, which include an edge effect, are used to analyze the device.


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