TITLE

Effect of maternal asthma, exacerbations and asthma medication use on congenital malformations in offspring: a UK population-based study

AUTHOR(S)
Tata, L. J.; Lewis, S. A.; McKeever, T. M.; Smith, C. J. P.; Doyle, P.; Smeeth, L.; Gibson, J. E.; Hubbard, R. B.
PUB. DATE
November 2008
SOURCE
Thorax;Nov2008, Vol. 63 Issue 11, p981
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: Clinical advice to pregnant women with asthma is to maintain optimal therapeutic management; however, potential adverse effects of asthma treatments on fetal development remain uncertain. A study was undertaken to assess the association between maternal asthma and gestational exposure to asthma medications with risk of congenital malformation in offspring.Methods: A matched case-control study was performed using The Health Improvement Network primary care database. Children with malformations were matched to control children on birth year, general practice and singleton or twin delivery.Results: 5124 cases of liveborn children with major congenital malformations and 30,053 controls were included in the study. The risk of any malformation in children born to women with asthma was marginally higher than that in children born to women without asthma (adjusted OR 1.10, 95% CI 1.01 to 1.20). However, no association was present in children born to mothers receiving asthma treatment in the year before or during pregnancy (OR 1.06, 95% CI 0.94 to 1.20). In assessing teratogenicity of medications, no increased risk of malformation was found with gestational exposures to short- or long-acting beta agonists, inhaled corticosteroids, oral corticosteroids, other bronchodilators or cromones. These findings were similar for each of 11 system-specific malformation groups, except for an increase in musculo-skeletal system malformation associated with cromone exposure.Conclusions: Gestational exposure to commonly used asthma medications was found to be safe overall, although a moderate teratogenic risk of cromones cannot be excluded. There was some evidence of a small increased risk of congenital malformation in children born to women with asthma, but this was not explained by gestational exposure to asthma drugs.
ACCESSION #
35420161

 

Related Articles

  • How Do We Best Detect Toxic Effects of Drugs Taken During Pregnancy?: A EuroMap Paper. Lie, R.T.; Olsen, J.; de Vries, C.S.; Czeizel, A.; Bergman, U.; Sørensen, H.T.; Nielsen, G.L.; de Jong van den Berg, L.T.W.; Irgens, L.M.; Olesen, C.; Pedersen, L.; Larsen, H. // Drug Safety;2002, Vol. 25 Issue 1, p21 

    It is a major clinical and public health problem that there is no clear strategy as to how we best make use of information obtained when pregnant women take drugs. For this reason, some pregnant women are not treated as they should be and some are given drugs they should not use. We suggest a...

  • Treatment of asthma during pregnancy: more solid evidence needed. Cazzola, Mario; Matera, Maria Gabriella // Thorax;Nov2008, Vol. 63 Issue 11, p944 

    The article reports on the need of a more solid evidence leading to treatment of asthma during pregnancy. The author explains the association of risks in the development of congenital malformations with pregnant women undergoing asthma medications. An important study showed evidence of safe...

  • Accutane registry compulsory in US, but not Canada. Andresen, Margot // CMAJ: Canadian Medical Association Journal;6/6/2006, Vol. 174 Issue 12, p1701 

    Focuses on the efforts of the U.S. to mitigate the risk of birth defects associated with isotretinoin Accutane by requiring physicians and patients to register before they can prescribe or take the drug. Response of Canada to the move by the U.S.; Side effects of isotretinoin; Aim of the iPLEDGE...

  • Long-Term Use of Glatiramer Acetate by 11 Pregnant Women with Multiple Sclerosis. Fragoso, Yára D.; Finkelsztejn, Alessandro; Kaimen-Maciel, Damacio R.; Grzesiuk, Anderson K.; Gallina, Andre S.; Lopes, Josiane; Morales, Nivea M. O.; Alves-Leon, Soniza V.; de Almeida, Sandra M. G. // CNS Drugs;2010, Vol. 24 Issue 11, p969 

    Background: Glatiramer acetate is a US FDA category B drug with regard to use by pregnant women with multiple sclerosis (MS). There are no data currently available for the continuous use of glatiramer acetate during pregnancy. Objective: To assess the risks and benefits of glatiramer acetate...

  • Maternal Asthma Medication Use and the Risk of Gastroschisis. Shao Lin; Jean Pierre W. Munsie; Michele L. Herdt-Losavio; Erin Bell; Charlotte Druschel; Paul A. Romitti; Richard Olney; the National Birth Defects Prevention Study // American Journal of Epidemiology;Jul2008, Vol. 168 Issue 1, p73 

    The objective of this study was to examine the association between maternal asthma medication use during the periconceptional period and the risk of gastroschisis. In this case-control study, the authors used data on deliveries enrolled in the National Birth Defects Prevention Study...

  • Maternal Asthma Medication Use and the Risk of Gastroschisis. Shao Lin; Jean Pierre W. Munsie; Michele L. Herdt-Losavio; Erin Bell; Charlotte Druschel; Paul A. Romitti; Richard Olney; the National Birth Defects Prevention Study // American Journal of Epidemiology;Jul2008, Vol. 168 Issue 1, p73 

    The objective of this study was to examine the association between maternal asthma medication use during the periconceptional period and the risk of gastroschisis. In this case-control study, the authors used data on deliveries enrolled in the National Birth Defects Prevention Study...

  • Teratogenic mechanisms of medical drugs. Van Gelder, Marleen M. H. J.; Van Rooij, Iris A. L. M.; Miller, Richard K.; Zielhuis, Gerhard A.; Den Berg, Lolkje T. W. de Jong-van; Roeleveld, Nel // Human Reproduction Update;Jul2010, Vol. 16 Issue 4, p378 

    BACKGROUND: Although prescription drug use is common during pregnancy, the human teratogenic risks are undetermined for more than 90% of drug treatments approved in the USA during the past decades. A particular birth defect may have its origins through multiple mechanisms and possible exposures,...

  • Slipping Back Into Depression. Querna, Betsy // U.S. News & World Report;2/13/2006, Vol. 140 Issue 5, p58 

    This article reports on depression and pregnant women, focusing on women who continued to take antidepressants while pregnant and those who gave them up. The pros and cons of taking antidepressants while pregnant are discussed. Some antidepressants, such as Paxil, are associated with birth...

  • Asthma puts babies at greater risk for birth defects.  // Infectious Diseases in Children;Jul2008, Vol. 21 Issue 7, p28 

    The article reports on the findings of a study conducted by researchers from Université de Montréal regarding the impact of asthma in pregnant women on their offspring. The research noted that the risk of birth defects is increased when uncontrollable asthma during the first trimester of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics