TITLE

Insulin resistance and daytime sleepiness in patients with sleep apnoea

AUTHOR(S)
Barceló, A.; Barbé, F.; de Ia Peña, M.; Martinez, P.; Soriano, J. B.; Piérola,, J.; Agusti, A.G. N.
PUB. DATE
November 2008
SOURCE
Thorax;Nov2008, Vol. 63 Issue 11, p946
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Excessive daytime sleepiness (EDS), obesity and insulin resistance (IR) occur frequently in patients with obstructive sleep apnoea syndrome (OSAS). We hypothesised that in these patients, EDS is a marker of IR, independent of obesity. Methods: We studied 44 patients with OSAS (22 with and 22 without EDS) matched for age (±5 years), body mass index (BMI ±3 kg/m²) and severity of OSAS (as determined by the apnoea-hypopnoea index (AHI)), and 23 healthy controls. Patients (n = 35) were re-examined after 3 months of effective therapy with continuous positive airway pressure (CPAP). EDS was assessed by both subjective (Epworth Sleepiness Scale) and objective (Multiple Sleep Latency Test) methods. IA was deter- mined by the HOMA index. Serum levels of glucose, triglycerides, cholesterol, cortisol, insulin, thyrotropin, growth hormone and insulin-like growth factor I (IGF-l) were also determined. Results: Despite the fact that age, BMI and AHI were similar, patients with EDS had higher plasma levels of glucose (p<0.05) and insulin (p<0.01), as well as evidence of IR (p<0.01) compared with patients without EDS or healthy controls. CPAP treatment reduced cholesterol, insulin and the HOMA index and increased IGF-1 levels in patients with EDS, but did not modify any of these variables in patients without EDS. Conclusion: EDS in OSAS is associated with IA, independent of obesity. Hence EDS may be a useful clinical marker to identify patients with OSAS at risk of metabolic syndrome.
ACCESSION #
35420153

 

Related Articles

  • Sleep apnoea and sleep breathing disorders. O'Reilly, John // British Journal of Hospital Medicine (17508460);Jun2009, Vol. 70 Issue 6, p320 

    Sleep apnoea and related sleep breathing disorders are a major cause of medical, social and occupational disability. Excessive sleepiness may be associated with respiratory failure, obesity, hypertension and insulin resistance in the cardiometabolic syndrome. This article reviews practical...

  • Risk for obstructive sleep apnea in obese, nondiabetic adults varies with insulin resistance status. Liu, Alice; Kushida, Clete; Reaven, Gerald // Sleep & Breathing;Mar2013, Vol. 17 Issue 1, p333 

    Purpose: Obstructive sleep apnea (OSA) is an increasingly common sleep disorder, especially among obese adults. Early identification of adults at risk for OSA would be of substantial benefit; however, the magnitude of the obesity epidemic requires that screening be performed judiciously. The...

  • Daytime Sleepiness a Possible Marker for Insulin Resistance.  // Pulmonary Reviews;Dec2008, Vol. 13 Issue 12, p20 

    The article discusses research being done on insulin resistance and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea syndrome (OSAS.) It references a study by Antonia Barcelo et al published in the November 2008 issue of "Thorax." Findings show that EDS is associated...

  • Obstructive sleep apnoea, insulin resistance and sleepiness. Ip, Mary S.M. // Thorax;Nov2008, Vol. 63 Issue 11, p939 

    The article discusses the implications of insulin resistance and sleepiness in obstructive sleep apnoea (OSA). The author reports on the issues concerning the relationship of daytime sleepiness in the condition connecting it to manifestations of various abnormalities and metabolic dysfunction....

  • The need for co-ordinated studies for obesity-related problems like diabetes mellitus in Libyan population. Sheriff, Dhastagir S.; Alshaari, Abdul Aziz; Manopriya, Thiruvagounder // Libyan Journal of Medicine;Jan2012, Vol. 7 Issue 1, p1 

    The author discusses the research methods to study obesity and obesity-related disorders in Libya. He notes that obesity is reported to affect insulin action by changing the secretion of adipocytokines that leads to proinflammatory conditions. He also notes a pathophysiological link shown...

  • Continuous Positive Airway Pressure Treatment in Patients with Sleep Apnoea: Does it Really Improve Glucose Metabolism? Steiropoulos, Paschalis; Papanas, Nikolaos; Nena, Evangelia; Maltezos, Efstratios; Bouros, Demosthenes // Current Diabetes Reviews;2010, Vol. 6 Issue 3, p156 

    Obstructive Sleep Apnoea Syndrome (OSAS) is a common disorder, characterised by repetitive episodes of partial or complete obstruction of the upper airway during sleep and associated with increasing respiratory efforts. These perturbations lead, in turn, to oxyhaemoglobin desaturation, sleep...

  • The Association Between Insulin Resistance and Obstructive Sleep Apnea. Sato, Tatsuya; Kasai, Takatoshi; Dohi, Tomotaka; Takaya, Hisashi; Kawana, Fusae; Narui, Koji // Diabetes;Jun2007 Supplement 1, Vol. 56, pA628 

    The insulin resistance OR) is often observed in patients with obstructive sleep apnea (OSA) and it was suggested that the IR in OSA patients was associated with underlying obesity. However, the repetitive episodes of apnea and hypopnea during sleep in patients with OSA, result in sympathetic...

  • OBESITY, INSULIN RESISTANCE AND NOCTURNAL OXYHAEMOGLOBIN SATURATION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA AND DAYTIME SLEEPINESS. Dumitrache-Rujinski, Şt.; Calcaianu, G.; Zaharia, D.; Dinu, Ioana; Toma, Claudia Lucia; Bogdan, M. // Internal Medicine / Medicina Interna;2013, Vol. 10 Issue 3, p31 

    Background. Obesity and obstructive sleep apnea syndrome (OSAS) are two prevalent conditions and risk factors for metabolic abnormalities. Thus, it is difficult to demonstrate an independent causal effect of OSAS in the occurrence of metabolic derangements. Aim: to evaluate the relation between...

  • Obstructive sleep apnoea.  // Thorax;Dec2006 Supplement 2, Vol. 61, pii78 

    The article presents abstracts of medical research related to obstructive sleep apnoea. They include "The Understanding and Comprehensibility of Pictograms Used in a New Screening Tool for Sleepiness and Obstructive Sleep Apnoea Syndrome," "Prevalence and Clinical Characteristics of Obesity...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics