TITLE

Human thyroid tumours, the puzzling lessons from E7 and RET/PTC3 transgenic mice

AUTHOR(S)
Jin, L.; Burniat, A.; Dumont, J.-E.; Miot, F.; Corvilain, B.; Franc, B.
PUB. DATE
December 2008
SOURCE
British Journal of Cancer;12/2/2008, Vol. 99 Issue 11, p1874
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Human rearranged RET/PTC3 (papillary thyroid carcinoma) proto-oncogene and high-risk human papillomavirus (HPV) type 16 E7 oncogene induces in the mouse a neoplastic transformation of thyroid follicular cells. We present a detailed immuno-histological study (170 mouse thyroids: RET/PTC3, E7, wild type, 2- to 10-month-old) with cell cycle proliferation and signalling pathway indicators. The characteristics of both models are different. There is an ‘oncogene dependent’ cellular signature, maintained at all studied ages in the E7 model, less in the RET/PTC3 model. During tumour development a large heterogeneity occurred in the Tg-RET/PTC3 model within a same tumour or within a same thyroid lobe. The Tg-E7 model was less heterogeneous, with a dominant goitrous pattern. The solid tumour already described in the RET/PTC3 models associated with cribriform patterns, suggested ‘PTC spindle cell changes’ as in humans PTC rather than the equivalent of the solid human PTC. Proliferation and apoptosis in the two thyroid models are related to the causal oncogene rather than reflect a general tumorigenic process. The thyroids of RET/PTC3 mice appeared as a partial and transient model of human PTCs, whereas the Tg-E7 mice do not belong to the usual PTC type.British Journal of Cancer (2008) 99, 1874–1883. doi:10.1038/sj.bjc.6604740 www.bjcancer.com Published online 4 November 2008
ACCESSION #
35413567

 

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