Surgical treatment of benign neurogenic tumours of the mediastinum: a single institution report

Cardillo, Giuseppe; Carleo, Francesco; Khalil, Mohammed W.; Carbone, Luigi; Treggiari, Stefano; Salvadori, Lorenzo; Petrella, Lea; Martelli, Massimo
December 2008
European Journal of Cardio-Thoracic Surgery;Dec2008, Vol. 34 Issue 6, p1210
Academic Journal
Abstract: Objective: Neurogenic tumours of the mediastinum are uncommon neoplasms arising from nerve tissues within the thorax. We sought to evaluate and compare the outcome following surgical resection of such tumours by VATS, open thoracotomy, and by either combined with hemilaminectomy. Methods: From February 1992 to March 2007, 93 patients underwent surgical resection of neurogenic tumours of the mediastinum in our institution. A videothoracoscopic approach was used in 57 cases (61.3%) (group V), of which 44 underwent VATS only and 13 required conversion to open approach. In the remaining 36 cases, 32 patients underwent thoracotomy (group T) and 4 had combined procedure with the neurosurgeons (group N). Results: No postoperative mortality was reported. Postoperative morbidity rate was 23.6% (22/93; 14 of group T, 4 of group N, and 4 of group V; p <0.0001). Histology showed benign neurogenic tumours in all patients. Statistical analysis showed differences between the two groups (group V and T respectively) in mean operative time (111.3±58.2min vs 149.06±77.05min; p: 0.01), median postoperative stay (4 days vs 6 days p: 0.0009) and median postoperative pain on day 1, day 7 and 1 month after surgery (respectively p <0.0001, p <0.0001 and p: 0.001). At a mean follow-up of 73 months no patients showed recurrence of the tumour. Conclusions: VATS represents the gold standard for the treatment of benign neurogenic tumours of the mediastinum with better results in terms of morbidity, operative time, postoperative stay and postoperative pain compared to open approach. Dumbbell tumours require a combined thoracic and neurosurgical approach.


Related Articles

  • Surgical outcomes in patients with primary mediastinal non-seminomatous germ cell tumours and elevated post-chemotherapy serum tumour markers†. De Latour, Bertrand; Fadel, Elie; Mercier, Olaf; Mussot, Sacha; Fabre, Dominique; Fizazi, Karim; Dartevelle, Philippe // European Journal of Cardio-Thoracic Surgery;Jul2012, Vol. 42 Issue 1, p66 

    OBJECTIVE Platinum-based chemotherapy followed by surgical resection of residual masses has become the standard treatment of patients with primary mediastinal non-seminomatous germ cell tumours (NSGCTs). Persistent serum tumour marker (STM) elevation after chemotherapy usually indicates a poor...

  • The Volume—Outcome Conundrum. Kizer, Kenneth W. // New England Journal of Medicine;11/27/2003, Vol. 349 Issue 22, p2159 

    This article focuses on a study by Birkmeyer and colleagues which described outcome relation with respect to several types of cardiovascular procedures and cancer resections. For all the procedures studied, the finding that patients treated by high-volume surgeons had lower operative mortality...

  • Pulmonary metastases of breast cancer. When is resection indicated? Welter, Stefan; Jacobs, Jan; Krbek, Thomas; Tötsch, Martin; Stamatis, Georgios // European Journal of Cardio-Thoracic Surgery;Dec2008, Vol. 34 Issue 6, p1228 

    Abstract: Objective: While resection of pulmonary metastases is a common treatment in other primaries, the role of breast cancer metastasectomy is still unclear. The objective of the present study was to investigate the clinical outcome of our operated patients with pulmonary breast cancer...

  • Associations Between Hospital and Surgeon Procedure Volumes and Patient Outcomes After Ovarian Cancer Resection. Schrag, Deborah; Earle, Craig; Feng Xu; Panageas, Katherine S.; Yabroff, K. Robin; Bristow, Robert E.; Trimble, Edward L.; Warren, Joan L. // JNCI: Journal of the National Cancer Institute;2/1/2006, Vol. 98 Issue 3, p163 

    Background: Strong associations between provider (i.e., hospital or surgeon) procedure volumes and patient outcomes have been demonstrated for many types of cancer operation. We performed a population-based cohort study to examine these associations for ovarian cancer resections. Methods: We...

  • Functional outcome in patients with advanced head and neck cancer: surgery and reconstruction with free flaps versus primary radiochemotherapy. Tschiesner, Uta; Schuster, Lena; Strieth, Sebastian; Harréus, Ulrich // European Archives of Oto-Rhino-Laryngology;Feb2012, Vol. 269 Issue 2, p629 

    The objective was to compare functional outcome in patients with advanced head and neck cancer (HNC) treated with (a) surgical resection and reconstruction with microvascular free flaps (MVFF) followed by radiochemotherapy versus (b) primary radiochemotherapy (RCT) on the basis of the...

  • Comparison of minimally invasive and open colorectal resections for patients undergoing simultaneous R0 resection for liver metastases: a propensity score analysis. Lin, Qi; Ye, Qinghai; Zhu, Dexiang; Wei, Ye; Ren, Li; Zheng, Peng; Xu, Pingping; Ye, Lechi; Lv, Minzhi; Fan, Jia; Xu, Jianmin // International Journal of Colorectal Disease;Mar2015, Vol. 30 Issue 3, p385 

    Purpose: The role of minimally invasive colorectal resection for patients undergoing a simultaneous resection for synchronous liver metastases had not been established. This study compared the short- and long-term outcomes between minimally invasive and open colorectal resection for patients...

  • The Impact of Tumor Size on Long-Term Survival Outcomes After Resection of Solitary Hepatocellular Carcinoma: Single-Institution Experience with 2558 Patients. Hwang, Shin; Lee, Young-Joo; Kim, Ki-Hun; Ahn, Chul-Soo; Moon, Deok-Bog; Ha, Tae-Yong; Song, Gi-Won; Jung, Dong-Hwan; Lee, Sung-Gyu // Journal of Gastrointestinal Surgery;Jul2015, Vol. 19 Issue 7, p1281 

    Background: According to the 7th AJCC TNM staging system, solitary hepatocellular carcinoma (HCC) is classified as T1 or T2 based on microvascular invasion (MVI) regardless of tumor size. This study intended to evaluate the prognostic impact of tumor size on survival outcomes after macroscopic...

  • Visceral Obesity Predicts Fewer Lymph Node Metastases and Better Overall Survival in Colon Cancer. Park, Se; Lee, Hang; Doo, Eun; Lee, Kang; Jun, Dae; Lee, Oh; Han, Dong; Yoon, Byung; Choi, Ho // Journal of Gastrointestinal Surgery;Aug2015, Vol. 19 Issue 8, p1513 

    Background: The relationship between visceral obesity and colon cancer outcome has not been well studied. The goal of this study was to determine the impact of visceral obesity on lymph node (LN) metastasis and overall survival (OS) in colon cancer. Materials and Methods: Metastatic LN ratio...

  • Laparoscopic Versus Open Low Anterior Resection for Rectal Cancer: Results from the National Cancer Data Base. Nussbaum, Daniel; Speicher, Paul; Ganapathi, Asvin; Englum, Brian; Keenan, Jeffrey; Mantyh, Christopher; Migaly, John // Journal of Gastrointestinal Surgery;Jan2015, Vol. 19 Issue 1, p124 

    Background: While the use of laparoscopy has increased among patients undergoing colorectal surgery, there is ongoing debate regarding the oncologic equivalence of laparoscopy compared to open low anterior resection (LAR) for rectal cancer. Methods: The 2010-2011 NCDB was queried for patients...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics