TITLE

Effect of Micrometer-Scale Roughness of the Surface of Ti6A14V Pedicle Screws in Vitro and in Vivo

AUTHOR(S)
Schwartz, Zvi; Raz, Perry; Ge Zhao; Barak, Yael; Tauber, Michael; Hai Yao; Boyan, Barbara D.
PUB. DATE
November 2008
SOURCE
Journal of Bone & Joint Surgery, American Volume;Nov2008, Vol. 90-A Issue 11, p2485
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Titanium implants that have been grit-blasted and acid-etched to produce a rough microtopography support more bone integration than do smooth-surfaced implants. In vitro studies have suggested that this is due to a stimulatory effect on osteoblasts. It is not known if grit-blasted and acid-etched Ti6Al4V implants also stimulate osteoblasts and increase bone formation clinically. In this study, we examined the effects of micrometer-scale-structured Ti6Al4V surfaces on cell responses in vitro and on tissue responses in vivo. Methods: Ti6Al4V disks were either machined to produce smooth surfaces with an average roughness (Ra) of 0.2 μm or grit-blasted, resulting in an Ra of 2.0, 3.0, or 3.3 μm. Human osteoblast-like cells were cultured on the disks and on tissue culture polystyrene. The cell number, markers of osteoblast differentiation, and levels of local factors in the conditioned media were determined at confluence. In addition, Ti6AI4V pedicle screws with smooth or rough surfaces were implanted into the L4 and L5 vertebrae of fifteen two-year-old sheep. Osteointegration was evaluated at twelve weeks with histomorphometry and on the basis of removal torque. Results: The cell numbers on the Ti6AI4V surfaces were lower than those on the tissue culture polystyrene; the effect was greatest on the roughest surface. The alkaline-phosphatase-specific activity of cell lysates was decreased in a surface-dependent manner, whereas osteocalcin, prostaglandin E2, transforming growth factor-β1, and osteoprotegerin levels were higher on the rough surfaces. Bone-implant contact was greater around the rough-surfaced Ti6AI4V screws, and the torque needed to remove the rough screws from the bone was more than twice that required to remove the smooth screws. Conclusions: Increased micrometer-scale surface roughness increases osteoblast differentiation and local factor production in vitro, which may contribute to increased bone formation and osteointegration in vivo. There was a correlation between in vitro and in vivo observations, indicating that the use of screws with rough surfaces will result in better bone- implant contact and implant stability. Clinical Relevance: The osteointegration of screws with rough microtopographies is likely to be better than that of screws with smoother surfaces.
ACCESSION #
35282024

 

Related Articles

  • The Heat Upsetting Process for the Titanium Alloy Spherical Bone Screws. Jianguang Liu; Fenglei Liu; Huadong Liu; Yufeng Wang; Lidong Wang // Advanced Materials Research;2014, Vol. 1021, p15 

    An advanced heat upsetting technology was studied according to the characteristics of the titanium alloy medical bone screws with spherical head. First, the reasons that punch demoulding is difficult during the upsetting forming have been discussed. Then the forming way with countersunk head in...

  • Assessment of preload in carbon coated prosthetic screws. Dziedzic, Dilcele Silva Moreira; Nhata, Juliane; Jamcoski, Vanessa Helena; Dziedzic, Maurício // RSBO: Revista Sul-Brasileira de Odontologia;apr-jun2012, Vol. 9 Issue 2, p137 

    Introduction: The mechanical aspects of tightening screws over implants are important to ensure a successful prosthetic rehabilitation. Screw loosening is a common problem that can be avoided with passive adaptation of the components and an increased tensile force developed in the screw, a...

  • Fatigue strength of a wire passing through a cannulated screw: implications for closure of the sternum following cardiac surgery. Jutley, R S; Shepherd, D E T; Hukins, D W L // Proceedings of the Institution of Mechanical Engineers -- Part H;May2003, Vol. 217 Issue 3, p221 

    It has been proposed that the incidence of sternal dehiscence can be decreased by passing the wires used for sternotomy closure through cannulated screws. However, there is a potential risk of fatigue failure as a result of the wire moving against the screw, e.g. during coughing and sneezing....

  • Unacceptable variation in the core diameters of some AO type cancellous screws. Radford, W. J. P.; Pozo, J. L.; Muirhead-Allwood, W. F. G. // Journal of the Royal Society of Medicine;Jul1988, Vol. 81 Issue 7, p384 

    This study assesses the variability in core diameter of a series of cancellous screws and its effect on torque strength. Analysis of a series of 107 cancellous screws revealed a wide variation of the core diameters in our sample. Tests to evaluate the effect of this variation showed that...

  • BIOMECHANICAL AND HISTOMORPHOMETRIC ANALYSES OF MONOCORTICAL SCREWS AT PLACEMENT AND 6 WEEKS POSTINSERTION. Huja, S. S.; Rao, J.; Struckhoff, J. A.; Beck, F. M.; Litsky, A. S. // Journal of Oral Implantology;2006, Vol. 32 Issue 3, p110 

    Maxillofacial screws are increasingly being used in orthodontics to provide anchorage for tooth movement. The objective of this study was to determine the biomechanical stability as well as the bone tissue response of screws at 6 weeks postinsertion in a canine model. Seven skeletally mature...

  • Effective combination of bone substitute and screws in the jail technique: a biomechanical study of tibial depression fractures. Doht, Stefanie; Lehnert, Teresa; Frey, Sönke; Fehske, Kai; Jansen, Hendrik; Blunk, Torsten; Meffert, Rainer // International Orthopaedics;Oct2012, Vol. 36 Issue 10, p2121 

    Purpose: The aim of this study was to investigate a new drillable calcium phosphate cement (Norian drillable Synthes GmbH) as a bone substitute either alone or in combination with screws in the jail technique (Petersen et al. Unfallchirurg Mar 109(3):219-234, ; Petersen et al. Unfallchirurg Mar...

  • A Biomechanical Comparison of Two Patterns of Screw Insertion. Lichtblau, Sheldon; Gallina, Jessica; Nasser, Philip; Munyoki, Musyoka; Jepsen, Karl // Bulletin of the NYU Hospital for Joint Diseases;2008, Vol. 66 Issue 4, p269 

    Inserting a screw into a long bone introduces a stress riser that can predispose the bone to fracture. Where multiple screws are inserted this vulnerability, may he increased. It is thought that the pattern of screw insertion plays an important part in determining the susceptibility of the bone...

  • Interfacial sliding properties of bone screw materials and their effect on screw fixation strength. Koistinen, Arto P.; Korhonen, Hannu; Kröger, Heikki; Lappalainen, Reijo // Journal of Applied Biomaterials & Functional Materials;2014, Vol. 12 Issue 2, p90 

    Background: This study examined the effect of interfacial sliding and test material properties on the fixation strength and insertional properties of self-tapping bone screws. Various substitute materials (polyacetal [POM], poly(methyl methacrylate) [PMMA] and E-glass-filled Epoxy...

  • Ruptura de tornillos de un fijador externo en una fractura de diáfisis humeral. Una complicación inusual. Reporte de un caso. D., Cesáreo Trueba; B., Alfredo Pozzo; Orbezo, Félix Gil // Acta Ortopedica Mexicana;nov/dic2003, Vol. 17 Issue 6, p306 

    We report the case of an unusual complication of the external fixators (Orthofix) in a diaphyseal humeral fracture, a man 38 years old with good bone quality present an open comminuted fracture II in the distal part. Ten weeks after operation without any trauma he presented breakage of the three...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics