The serum levels of Th1 and Th2 cytokine profiles in patients with different stages of chronic kidney disease

Rafice, A. R.; Makhlough, A.; Nasab, S. Hashemi; Amiri, A. Hosseinian; F. Abedian
April 2008
Journal of Mazandaran University of Medical Sciences (JMUMS);2008, Vol. 18 Issue 63, p5
Academic Journal
Background and Purpose: Various abnormalities of the immune system have been demonstrated in patients with chronic kidney disease (CKD). Patients with CKD commonly present with abnormalities of immune function related with impaired kidney function and the accumulation of uremic toxins. Th1 and Th2 cells produce predominantly some cytokine profiles. The aim of the present study was the determination of the levels of IL- 13 and IFN-γ in sera of end-stage renal disease. The correlations of IL-13 and IFN-γ levels with clinical presentation of the disease were assessed. Materials and Methods: In this case-control study the serum levels of IL-13 and IFN-γ were determined by a sandwich enzyme-linked immunosorbent assay in 30 patients on hemodialysis (HD), 30 patients with chronic renal failure (CRF), and 60 healthy individuals . Renal function was evaluated by measuring serum levels of creatinin, albumin and urea. Results: The serum levels of IL- 13 and IFN-γ were differed significantly between patients and healthy controls. The serum levels of IL-l3 was significantly increased in the HD group than in the CRF and control groups (13.7± 3.9, 6.7± 3.4, 4.5±3.3 pg/ml, respectively) (P0.001). On the other hand, the IFN-γ plasma levels were significantly higher in CRF patients than HD patients and controls (38.8±18.8, 17.4±8.78, 12.5±8.9 pg/ml, respectively). Conclusion: In the HD patients, low production of IFN-γ in line with upregulation of IL-13 indicates that Th1/Th2 balance may shift towards Th2 dominance. It is possible that this imbalance contributes to the abnormality of the immune system in HD patients.


Related Articles

  • Plasma adiponectin levels and clinical outcomes among haemodialysis patients. Madhumathi Rao; Lijun Li; Hocine Tighiouart; Bertrand L. Jaber; Brian J. G. Pereira; Vaidyanathapuram S. Balakrishnan; the HEMO Study Group // Nephrology Dialysis Transplantation;Aug2008, Vol. 23 Issue 8, p2619 

    Background. Adiponectin (ADPN) levels are consistently elevated among patients with advanced chronic kidney disease, but its relationship with cardiovascular outcomes in this population remains controversial. Methods. We measured baseline and yearly plasma ADPN in 182 prevalent haemodialysis...

  • Evolution of chronic hypertensive nephropathies treated with ACE inhibitors on patients in pre-dialysis stage. Costea, Andreea-Cristina; Costea, DO; David, Cristiana; Grasa, CN // Journal of Medicine & Life;Apr-Jun2010, Vol. 3 Issue 2, p144 

    Arterial hypertension (HT), being the main factor of negative evolution for chronic nephropathies, has imposed a careful adjustment of pharmacological treatment. The widespread use of angiotensin conversion enzyme inhibitors (ACE inhibitors) has brought into attention the side effects of this...

  • Acute effect of hemodialysis on serum levels of the proinflammatory cytokines. Tarak�ioglu, Mehmet; Erbagci, Ayse Binnur; Usalan, Celalettin; Deveci, Rukiye; Kocabas, Ramazan // Mediators of Inflammation;Feb2003, Vol. 12 Issue 1, p15 

    CHRONIC inflammation is a common feature of end-stage renal disease, which carries a heightened risk of atherosclerosis and other co-morbid conditions. Dialysis treatment per se can bring additional risk factors for inflammation, such as increased risk of local graft and fistula infections,...

  • End-stage renal failure and regulatory activities of CD4+CD25bright+FoxP3+ T-cells. Hendrikx, Thijs K.; van Gurp, Eveline A. F. J.; Mol, Wendy M.; Schoordijk, Wenda; Sewgobind, Varsha D. K. D.; IJzermans, Jan N. M.; Weimar, Willem; Baan, Carla C. // Nephrology Dialysis Transplantation;Jun2009, Vol. 24 Issue 6, p1969 

    Background. The defensive immune system in patients with end-stage renal failure is impaired at multiple levels. This state of immune incompetence is associated with continuous activation of the immune system. An additional explanation for this state of activation may be the disturbed function...

  • Measurement of health related quality of life in children with chronic kidney disease using a specific test. Influence of treatment. López, C. Aparicio; Escribano, A. Fernández; García, E. Izquierdo; de Pablos, A. Luque; Cantanero, G. Garrido // Nefrologia;04/01/2010, Vol. 30 Issue 2, p177 

    Introduction: Chronic kidney disease (CKD) affects the daily life of the child especially during the stage where their personal development takes place. Adult renal patients have a demonstrated worse health related quality of life (HRQL) mainly under hemodialysis (HD), however there are few...

  • Factors associated with health-related quality of life among hemodialysis patients in the DOPPS. Lopes, Antonio; Bragg-Gresham, Jennifer; Goodkin, David; Fukuhara, Shunichi; Mapes, Donna; Young, Eric; Gillespie, Brenda; Akizawa, Tadao; Greenwood, Roger; Andreucci, Vittorio; Akiba, Takashi; Held, Philip; Port, Friedrich; Lopes, Antonio Alberto; Bragg-Gresham, Jennifer L; Goodkin, David A; Mapes, Donna L; Young, Eric W; Gillespie, Brenda W; Greenwood, Roger N // Quality of Life Research;May2007, Vol. 16 Issue 4, p545 

    Objective: To identify modifiable factors associated with health-related quality of life (HRQOL) among chronic hemodialysis patients.Methods: Analysis of baseline data of 9,526 hemodialysis patients from seven countries enrolled in phase I of the Dialysis Outcomes and...

  • Quality of Life of Caregivers and Patients Undergoing Haemodialysis at Ministry of Health, Jordan. Shdaifat, Emad A.; Manaf, Mohd R. Abdul // International Journal of Applied Science & Technology;Mar2012, Vol. 2 Issue 3, p75 

    Quality of life (QOL) has become an important aspect in assessing the burden of chronic disease. A cross-sectional study was conducted from August to November 2010 at Ministry of Health (MOH), Jordan. The aims of the study were; to measure the patients' and caregivers' QOL, and subsequently to...

  • Mortality in dialysis patients may not be associated with ESA dose: a 2-year prospective observational study. McMahon, Lawrence P.; Cai, Michael X.; Baweja, Sanjeev; Holt, Stephen G.; Kent, Annette B.; Perkovic, Vlado; Leikis, Murray J.; Becker, Gavin J. // BMC Nephrology;2012, Vol. 13 Issue 1, p40 

    Background: Anaemia of chronic kidney disease increases the risk of death and adverse events, but can be managed using erythropoiesis stimulating agents (ESAs). However, recent evidence suggests that targeting a higher haemoglobin concentration ([Hb]) increases mortality risk, and both higher...

  • Cellular and Molecular Pathways that Lead to Progression and Regression of Renal Fibrogenesis. Okada, Hirokazu; Kalluri, Raghu // Current Molecular Medicine;Aug2005, Vol. 5 Issue 5, p467 

    Renal fibrosis is a common consequence and often a central feature of all the progressive renal diseases that lead to end-stage renal failure. In comparison to wound healing, during kidney fibrosis the length of the post-inflammatory phase often exceeds and continues unchecked resulting in scar...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics