TITLE

Host- rather than virus-related factors reduce health- related quality of life in hepatitis C virus infection

AUTHOR(S)
Helbling, B.; Overbeck, K.; Gonvers, J.-J.; Malinverni, A.; Dufour, J.-F.; Borovicka, J.; Heim, M.; Cerny, A.; Negro, F.; Bucher, S.; Rickenbach, M.; Aenner, E. L.; Mullhaupt, B.
PUB. DATE
November 2008
SOURCE
Gut;Nov2008, Vol. 57 Issue 11, p1597
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Hepatitis C virus (HCV) infection is associated with decreased health-related quality of life (HAQOL). Although HCV has been suggested to directly impair neuropsychiatric functions, other factors may also play a role. Patients and methods: In this cross-sectional study, we assessed the impact of various host-, diseaseand virusrelated factors on HRQOL in a large, unselected population of anti-HCV-positive subjects. All individuals (n = 1736) enrolled in the Swiss Hepatitis C Cohort Study (SCCS) were asked to complete the Short Form 36 (SF-36) and the Hospital Anxiety Depression Scale (HADS). Results: 833 patients (48%) returned the questionnaires. Survey participants had significantly worse scores in both assessment instruments when compared to a general population. By multivariable analysis, reduced HRQOL (mental and physical summary scores of SF-36) was independently associated with income. In addition, a low physical summary score was associated with age and diabetes, whereas a low mental summary score was associated with intravenous drug use. HADS anxiety and depression scores were independently associated with income and intravenous drug use. In addition, HADS depression score was associated with diabetes. None of the SF-36 or HADS scores correlated with either the presence or the level of serum HCV RNA. In particular, SF36 and HADS scores were comparable in 555 HCV RNA-positive and 262 HCV RNA-negative individuals. Conclusions: Anti-HCV-positive subjects have decreased HAQOL compared to controls. The magnitude of this decrease was clinically important for the SF-36 vitality score. Host and environmental, rather than viral factors, seem to impact on HRQOL level.
ACCESSION #
35151085

 

Related Articles

  • Does the care dependency of nursing home residents influence their health-related quality of life?-A cross-sectional study. Tabali, Manuela; Ostermann, Thomas; Jeschke, Elke; Dassen, Theo; Heinze, Cornelia // Health & Quality of Life Outcomes;2013, Vol. 11 Issue 1, p1 

    Background: Studies on health-related quality of life (HRQOL) are missing for nursing home residents independent from their health conditions or interventions after admission. Our aim was to analyse if the care dependency of nursing home residents influence their HRQOL and to describe HRQOL of...

  • Exploring the quality of life (QOL) in the Indian software industry: a public health viewpoint. Jha, Ayan; Sadhukhan, Sanjoy; Velusamy, Saravanan; Banerjee, Gargi; Banerjee, Arpita; Saha, Amitava; Talukdar, Sumit // International Journal of Public Health;Apr2012, Vol. 57 Issue 2, p371 

    Objectives: Our objectives were to describe the QOL and its determinants among software professionals of Kolkata, and to compare the same according to information technology (IT) and IT-enabled services (ITeS) sub-sectors. Methods: An institution-based cross-sectional study was conducted among...

  • Evaluation of health related quality of life in irritable bowel syndrome patients.  // Health & Quality of Life Outcomes;2012, Vol. 10 Issue 1, p12 

    The article presents a study examining the factors associated with quality of life (QOL) in Iranian irritable bowel syndrome patients (IBS). As mentioned, QOL was not different between IBS subtypes, and QOL was found to be inversely correlated with anxiety symptom. It is also mentioned that,...

  • Emigration-related attitudes of the final year medical students in Croatia: a cross-sectional study at the dawn of the EU accession. Kolčić, Ivana; Čikeš, Mihaela; Boban, Kristina; Bućan, Jasna; Likić, Robert; Ćurić, Goran; Đogaš, Zoran; Polašek, Ozren // Croatian Medical Journal;Oct2014, Vol. 55 Issue 5, p452 

    Aim: To investigate the emigration-related attitudes of final year medical students in Croatia at the dawn of the EU accession in 2013. Methods: All final-year medical students at four Croatian medical schools (Zagreb, Rijeka, Split, and Osijek) were invited to participate in a cross-sectional...

  • Baixo peso e dependência funcional em idosos institucionalizados de Uberlândia (MG), Brasil. de Sousa, Kamilla Tavares; de Mesquita, Laura Anália Silva; Pereira, Leandro Alves; Azeredo, Catarina Machado // Revista Ciência & Saúde Coletiva;ago2014, Vol. 19 Issue 8, p3513 

    This article seeks to identify the association between nutritional status and functional dependence in institutionalized elderly interns in Uberlândia, Minas Gerais. It involved a cross-sectional study with 233 elderly interns in which sociodemographic variables, nutritional status and degree...

  • Unhealthy Days and Quality of Life in Irish Patients with Diabetes. Clifford, Emma Louise; Collins, Margaret M.; Buckley, Claire M.; Fitzgerald, Anthony P.; Perry, Ivan J. // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    Objectives: To study the determinants of health-related quality of life (HRQoL) in Irish patients with diabetes using the Centres for Disease Controls' (CDC's) ‘Unhealthy Days’ summary measure and to assesses the agreement between this generic HRQoL measure and the disease-specific...

  • Promising insights into the health related quality of life for children with severe obesity. Selewski, David T.; Collier, David N.; MacHardy, Jackie; Gross, Heather E.; Pickens, Edward M.; Cooper, Alan W.; Bullock, Selam; Earls, Marian F.; Pratt, Keeley J.; Scanlon, Kelli; McNeill, Jonathan D.; Messer, Kassandra L.; Yee Lu; Thissen, David; DeWalt, Darren A.; Gipson, Debbie S. // Health & Quality of Life Outcomes;2013, Vol. 11 Issue 1, p1 

    Background: Childhood obesity is a growing health concern known to adversely affect quality of life in children and adolescents. The Patient Reported Outcomes Measurement Information System (PROMIS) pediatric measures were developed to capture child self-reports across a variety of health...

  • Health-re1ated quality of life and its relationship with clinical symptoms among Iranian patients with polycystic ovarian syndrome. Bazarganipour, Fatemeh; Ziaei, Saeide; Montazeri, Ali; Foroozanfard, Fatemeh; Faghihzadeh, Soghrat // Iranian Journal of Reproductive Medicine;May2013, Vol. 11 Issue 5, p371 

    Background: Polycystic ovarian syndrome (PCOS) has been shown to cause a reduction in Health-related quality of life (HRQOL). Objective: This study examines the extent of different clinical symptoms in PCOS patients on HRQOL. Materials and Methods: A cross-sectional study was undertaken to...

  • Hepatitis C Virus Infection as a Traumatic Experience. Morais-de-Jesus, Mychelle; Daltro-Oliveira, Renato; Pettersen, Karine Miranda; Dantas-Duarte, Adriana; Amaral, Luciana Di-Domizio; Cavalcanti-Ribeiro, Patrícia; Santos, Carlos Teles; Schinoni, Maria Isabel; Netto, Liana R.; Araújo-de-Freitas, Lucas; Paraná, Raymundo; Miranda-Scippa, Ângela; Koenen, Karestan C.; Quarantini, Lucas C. // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Objective: The purpose of this study was to evaluate whether individuals consider their HCV infection to be a potentially traumatic experience. Additionally, we investigated its association with Post-Traumatic Stress Disorder (PTSD) and the impact of PTSD diagnosis on health-related quality of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics