TITLE

Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition

AUTHOR(S)
Fujisawa, T.; Endo, H.; Tomimoto, A.; Sugiyama, M.; Takahashi, H.; Saito, S.; Inamori, M.; Nakajima, N.; Watanabe, M.; Kubota, N.; Yamauchi, T.; Kadowaki, T.; Wada, K.; Nakagama, H.; Nakajima, A.
PUB. DATE
November 2008
SOURCE
Gut;Nov2008, Vol. 57 Issue 11, p1531
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: The effect of adiponectin on colorectal carcinogenesis has been proposed but not fully investigated. We investigated the effect of adiponectin deficiency on the development of colorectal cancer. Methods: We generated three types of gene-deficient mice (adiponectin-deficient, adiponectin receptor 1- deficient, and adiponectin receptor 2-deficient) and investigated chemical-induced colon polyp formation and cell proliferation in colon epithelium. Western blot analysis was performed to elucidate the mechanism which affected colorectal carcinogenesis by adiponectin defi- ciency. Results: The numbers of colon polyps were significantly increased in adiponectin-deficient mice compared with wild-type mice fed a high-fat diet. However, no difference was observed between wild-type and adiponectin- deficient mice fed a basal diet. A significant increase in cell proliferative activity was also observed in the colonic epithelium of the adiponectin-deficient mice when compared with wild-type mice fed a high-fat diet; however, no difference was observed between wild-type and adiponectin-deficient mice fed a basal diet. Similarly, an increase in epithelial cell proliferation was observed in adiponectin receptor 1-deficient mice, but not in adiponectin receptor 2-deficient mice. Western blot analysis revealed activation of mammalian target of rapamycin, p70 S6 kinase, S6 protein and inactivation of AMP-activated protein kinase in the colon epithelium of adiponectin-deficient mice fed with high-fat diet. Conclusions: Adiponectin suppresses colonic epithelial proliferation via inhibition of the mammalian target of the rapamycin pathway under a high-fat diet, but not under a basal diet. These studies indicate a novel mechanism of suppression of colorectal carcinogenesis induced by a Western-style high-fat diet.
ACCESSION #
35151073

 

Related Articles

  • Advances in adipose tissue metabolism. Lafontan, M. // International Journal of Obesity;Dec2008 Supplement 7, Vol. 32, pS39 

    This review will focus on the recent findings in adipose tissue metabolism with special attention to human adipocyte biology and physiology. There are major advances stemming from the concomitant results obtained from studies on mature human adipocytes, human preadipocytes differentiated in...

  • Forkhead Transcription Factor Fox01 in Adipose Tissue Regulates Energy Storage and Expenditure. Nakae, Jun; Yongheng Cao; Oki, Miyo; Orba, Yasuko; Sawa, Hirofumi; Kiyonari, Hiroshi; Iskandar, Kristy; Suga, Koji; Lombes, Marc; Hayashi, Yoshitake // Diabetes;Mar2008, Vol. 57 Issue 3, p563 

    OBJECTIVE--Adipose tissue serves as an integrator of various physiological pathways, energy balance, and glucose homeostasis. Forkhead box-containing protein O subfamily (FoxO) 1 mediates insulin action at the transcriptional level. However, physiological roles of FoxO1 in adipose tissue remain...

  • Pharmacological Effects of the Water Fraction of Key Components in the Traditional Chinese Prescription Mai Tong Fang on 3T3-L1 Adipocytes and ob/ob Diabetic Mice. Liang Ma; Li Huang; Heying Pei; Zhuowei Liu; Caifeng Xie; Lei Lei; Xiaoxin Chen; Haoyu Ye; Aihua Peng; Lijuan Chen // Molecules;Sep2014, Vol. 19 Issue 9, p14687 

    Mai Tong Fang (MTF), a Chinese herbal combination, has been used for the treatment of diabetic nephropathy in traditional medical clinics in China. However, the antiadipogenic and anti-hyperglycemic effects of MTF have not been fully elucidated, so this study explored these pharmacological...

  • Stay lean without dieting. Huot, Marc-Étienne; Richard, Stéphane // Adipocyte;Oct-Dec2012, Vol. 1 Issue 4, p246 

    Alternative splicing is well known to be tissue-specific. Although several genes have been shown to undergo alternative splicing in adipocytes, little is known about the mechanism that regulates alternative splicing during adipogenesis. We recently reported that Sam68-/- mice exhibit a lean...

  • Retinol-Binding Protein 4 in Human Obesity. Janke, Jürgen; Engeli, Stefan; Boschmann, Michael; Adams, Frauke; Böhnke, Jana; Luft, Friedrich C.; Sharma, Arya M.; Jordan, Jens // Diabetes;Oct2006, Vol. 55 Issue 10, p2805 

    Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans. RBP4 was highly expressed in isolated mature human adipocytes and secreted by...

  • Depletion of white adipocyte progenitors induces beige adipocyte differentiation and suppresses obesity development. Daquinag, A C; Tseng, C; Salameh, A; Zhang, Y; Amaya-Manzanares, F; Dadbin, A; Florez, F; Xu, Y; Tong, Q; Kolonin, M G // Cell Death & Differentiation;Feb2015, Vol. 22 Issue 2, p351 

    Overgrowth of white adipose tissue (WAT) in obesity occurs as a result of adipocyte hypertrophy and hyperplasia. Expansion and renewal of adipocytes relies on proliferation and differentiation of white adipocyte progenitors (WAP); however, the requirement of WAP for obesity development has not...

  • Deletion of Serum Amyloid A3 Improves High Fat High Sucrose Diet-Induced Adipose Tissue Inflammation and Hyperlipidemia in Female Mice. den Hartigh, Laura J.; Wang, Shari; Goodspeed, Leela; Ding, Yilei; Averill, Michelle; Subramanian, Savitha; Wietecha, Tomasz; O'Brien, Kevin D.; Chait, Alan // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Serum amyloid A (SAA) increases in response to acute inflammatory stimuli and is modestly and chronically elevated in obesity. SAA3, an inducible form of SAA, is highly expressed in adipose tissue in obese mice where it promotes monocyte chemotaxis, providing a mechanism for the macrophage...

  • News about Fat Cells. Bliss, Rosalie Marion // Agricultural Research;Mar2006, Vol. 54 Issue 3, p4 

    The article reports on the results of a study on fat cells. The new study explains important aspects of these immune cells in body fat, such as why they infiltrate, how they function and just where they gather. The fat cells, or adipocytes, within this tissue have several functions, such as...

  • Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth. Klöting, Nora; Koch, Linda; Wunderlich, Thomas; Kern, Matthias; Ruschke, Karen; Krone, Wilhelm; Brüning, Jens C.; Blüher, Matthias // Diabetes;Aug2008, Vol. 57 Issue 8, p2074 

    OBJECTIVE--IGF-1 and the IGF-1 receptor (IGF-1R) have been implicated in the regulation of adipocyte differentiation and lipid accumulation in vitro. RESEARCH DESIGN AND METHODS--To investigate the role of IGF-1 receptor in vivo, we have inactivated the Igf-1r gene in adipose tissue (IGF-1R[sup...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics