Relationship between symptoms and ingestion of a meal in functional dyspepsia

Bisschops, R.; Karamanolis, G.; Arts, J.; Caenepeel, P.; Verbeke, K.; Janssens, J.; Tack, J.
November 2008
Gut;Nov2008, Vol. 57 Issue 11, p1495
Academic Journal
Backgound and aims: A subset of functional dyspepsia (FD) patients report meal-related symptoms, possibly representing a pathophysiologically homogeneous subgroup. The aim of the present study was to establish the time-course of symptoms in relation to meal ingestion, and to assess the relationship between self-reported meal-related symptoms and pathophysiological mechanisms in FD. Methods: 218 FD patients (149 women, mean (SEM) age 39 (1) years) filled out a symptom questionnaire, including meal-induced aggravation. All patients underwent a gastric emptying breath test with severity (0-4) scoring of six symptoms (pain, fullness, bloating, nausea, burning and belching) at each sampling (15 mm interval for 4 h). In 129 patients, gastric sensitivity and accommodation were assessed by barostat. Results: The intensity of each FO symptom was significantly increased 15 mm after the meal, compared with the premeal score, and remained elevated until the end of the measurement period (all p


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