Spontaneous Hepatitis C Virus Clearance in HIV-Infected Patients: New Insights for Improving Management

Bruno, Raffaele; Sacchi, Paolo
November 2008
Journal of Infectious Diseases;11/1/2008, Vol. 198 Issue 9, p1262
Academic Journal
The article reflects on the implication of hepatitis C virus to patients in the U.S. It was found that progressive chronic liver disease associated with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection cause morbidity and mortality in patients infected with HIV. Figures shows that one-third of HIV-infected individuals are coinfected with HCV while 10%-45% will die from complications associated with HCV-related liver disease. Studies shows that infection with HIV exacerbates the natural history of chronic HBV and HCV infection. The successful control of viral infections depends on the generation and maintenance of long-lasting specific memory CD4 T cells, which support the production of antibodies and the function of specific CD8 T cells.


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