TITLE

Improvement of left ventricular myocardial short- axis, but not long-axis function or torsion after cardiac resynchronisation therapy: an assessment by two-dimensional speckle tracking

AUTHOR(S)
Zhang, Q.; Fung, J. W.-H.; Yip, G. W. K.; Chan, J. Y.-S.; Lee, A. P.-W.; Lam, Y.-Y.; Wu, L.-W.; Wu, E. B.; Yu, C.-M.
PUB. DATE
November 2008
SOURCE
Heart;Nov2008, Vol. 94 Issue 11, p1464
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aims: To evaluate whether short-axis function plays a part in determining left ventricular (LV) geometric and functional improvement after cardiac resynchronisation therapy (CAT). Methods and results: 39 patients who received CAT were enrolled. 2D speckle tracking echocardiography was performed at baseline and three months after CAT to assess mean systolic circumferential (8-circum), radial (c- radial) and longitudinal (c-long) strain and torsion. Aesponders of reverse remodelling )n = 21) had higher baseline mean c-circum than non-responders (p<0.05), who also had improvement in mean c-circum and mean c-radial (both p<0.05) after CAT. Also, the increase in mean c-circum correlated with increase in ejection fraction (r = 0.57, p<0.001) and decrease in mid-cavity width (r= -0.52, p = 0.001). A baseline mean c-circum of ≥6.5% predicted a gain in ejection fraction ≥5%, with a sensitivity of 73% and a specificity of 71%. The baseline c-long was not different between the two groups, and remained unchanged after CAT. The torsion did not improve in responders, but was worsened in non-responders (p<0.05). Conclusions: The improvement of LV short-axis function but not long-axis function or torsion contributes to the improvement in LV global function and geometry at three-month follow up. A relatively preserved mean c-circum of ≥6.5% might be useful to predict favourable responses after CAT.
ACCESSION #
35131539

 

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