TITLE

Combined Gum Acacia of Meloxicam therapy versus Meloxicam monotherapy : A Biochemical and Histopathological Study

AUTHOR(S)
El-Saeid, M. E. El-Bawab; H. Abdel-Rahman, Ahmed; H. Osman, Hosam; Ibrahim, Atif
PUB. DATE
June 2008
SOURCE
Egyptian Journal of Hospital Medicine;Jun2008, Vol. 31, p244
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To study the protective action of Gum Acacia against the damaging effects of,meloxicam on intestine and digestive enzymes Study design: This study was performed on thirty albino rats divided into three groups each group contains 10 rats, the first group treated with meloxicam only , the second group treated with meloxicam and Gum Acacia and the third group acts as controls. After 21 days of feeding, all rats were killed, the activity of digestive enzymes ; lipase (intestinal & pancreatic), amylase(pancreatic & intestinal).Also lactate dehydrogenase (LDH) & alkaline phosphatase (ALP) activities were assayed. In addition, the histopathological examination of intestinal tissues were carried out. Results: The first group showed a significant decrease (P<0.001) in pancreatic lipase and amylase activities together with a significant increase (P<0.001) in the intestinal amylase, lipase, alkaline phosphatase ( ALP) and lactate dehydrogenase (LDH) activities when compared with controls. The second group showed a significant increase (P<0.001) in pancreatic and intestinal lipase and amylase activities as well as in intestinal ALP and LDH activities when compared to the controls. Histopathologically, there were an intestinal epithelial damage (shedding of the mucosa with focal inflammation) in meloxicam treated group. But, the co-treated rat group displayed small changes of denuded intestinal mucosa.. Conclusion: Our study concluded that gum acacia exhibits a protective action that can antagonize the damaging effects of meloxicam therapy.
ACCESSION #
35129585

 

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