TITLE

Biochemical Studies On The Effect Of Ponceau 4r And/Or Vitamin E Treatment On Young Male Albino Rats

AUTHOR(S)
Helal, Eman; M., Al-Kassas; Soliman, Ghada Z. A.; S., Zahkok; H., Abdel Wahed
PUB. DATE
June 2008
SOURCE
Egyptian Journal of Hospital Medicine;Jun2008, Vol. 31, p233
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Due to now a day's high technology, which make foods more attractable to children. This study aims to study the effect of Ponceau 4R (food colorant) and/or vitamin E (antioxidant) on rats. Material And Methods: Certain parameters were measured as percentage of body weight change, body temperature, heart beat, Red & white blood cells count, hemoglobin concentration, hematocrite value, serum total lipids, serum cholesterol, serum total protein, serum albumin, globulin, A/G ratio, serum glucose, serum alanine transaminase and aspartate transaminase (ALT & AST) activity and serum total cholinesterase. The organs (brain, liver, kidney, heart and skeletal muscle) were removed, cleared then weighted. Organs were prepared for total protein, total lipid determination and other biochemical analysis. Results: Body weight, respiration rate was significantly decreased till the 3rd month followed by a significant increase till the 6th month. WBCs count; serum total lipids, liver total lipids, serum glucose, serum cholinesterase activity were significantly reduced. Muscle total lipids, serum total cholesterol, serum total protein, serum total albumin, serum AST activity, liver AST activity were significantly increased. Conclusion: Due to the hazardous effect of food colourants as Ponceau 4R, it is recommended that the use of Ponceau 4R as food colourant must be limited and use vitamin E as antioxidant to prevent the toxic effect of food colouring substance.
ACCESSION #
35129584

 

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