Molecular Study on Cytokine Gene Polymorphism among Cases of Psoriasis

Settin, Ahmad; Hassan, Hanaa A.; El-Baz, Rizk; Hassan, Tahai A.
June 2008
Egyptian Journal of Hospital Medicine;Jun2008, Vol. 31, p222
Academic Journal
Background: Psoriasis is a chronic inflammatory skin disease that varies in age and mode of onset, severity, course, duration and clinical morphology from one individual to another. Objectives: To check for the association of polymorphisms of cytokine genes with the susceptibility and severity of Psoriasis in cases from Egypt. Subjects: 46 cases with Psoriasis in addition to 98 healthy unrelated controls. Cases were classified into aggressive or early onset Psoriasis (17 cases, 36.9%) and late onset Psoriasis (29 cases, 63.1%). Methods: DNA was amplified using PCR-SSP for detection of polymorphisms related to TNF-α-308 (G/A), IL-10-1082 (G/A), IL-6-174 (G/C) and (IL-1 receptor antagonist) IL-1Ra (VNTR). Results: Total cases showed high significant frequency of homozygous IL-10-1082 (G/G) (OR=3.9, P<0.05), TNF-α-308 (G/G) (OR=3.7, P<0.05) and IL-6-174 C/C (OR=6.7, P<0.001). Where as early and late onset cases showed high significant frequency of homozygous for IL-6-174 (C/C) (P<0.05) only. On the other hand, combined heterozygosity for IL-6-174 (G/C) with IL-10-1082 (G/A) showed lowest significant frequency among all cases (P<0.05) and were considered low risk genotypes. Conclusions: Cytokine gene polymorphisms may be used as a marker for Psoriasis susceptibility, and severity helping for early diagnosis.


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