TITLE

Histological And Histochemical Studies After Partial Hepatoectomy In Liver And Spleen Of Rats

AUTHOR(S)
Motaal, Abdel
PUB. DATE
June 2008
SOURCE
Egyptian Journal of Hospital Medicine;Jun2008, Vol. 31, p165
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction :- The aim of this investigation is to study the effect of partial hepatoectomy on the histology and histochemistry of liver and spleen of male rats. Material And Methods:- Twenty four rats were used in the present study and were divided into four groups"six rats each".group(I) and classified into four groups: Negative control group (I). 6 rats and group (II) hepatoectomized rats were given sub. Cut 0.1 ml vitamin K 3 days consequently before surgical hepatectomy was performed. Histopathological examination of liver and spleen and frozen sections for alkaline phosphatase demonstration were undertaken in the 1st day, 7th day and 15th day following the surgical operation. Results:- The histopathological results were manifested in hepatoectomized rats as congested portal vein, vacuolation and pyknosis in liver cells, fibrosis inflammatory cells infiltration around hepatic vein and increasing kupffer cells. In splenic tissue the histopathological changes were in the form of ill defined pulps with marked congestion and necrotic nuclei. After 15th days of operation marked recovery in both white and red pulps were recorded. The histochemical examination of alkaline phosphatase revealed marked attenuation after 1th and 7th days of operation in both liver and spleen of hepatoectomized rats followed by regeneration after 15th day of operation in comparison to the control group.
ACCESSION #
35129576

 

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