The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor
- Synergism among Ternary Mixtures of Fourteen Sweeteners. Schiffman, Susan S.; Sattely-Miller, Elizabeth A.; Graham, Brevick G.; Booth, Barbara J.; Gibes, Kernon M. // Chemical Senses;Apr2000, Vol. 25 Issue 2, p131
The purpose of the present study was to determine the degree of synergism of sweet taste among ternary mixtures of 14 sweeteners. A trained panel evaluated ternary mixtures of 14 sweeteners varying in chemical structure and type. The ternary mixtures that were tested were limited to those in...
- From Aldrovandi's â€œHomuncioâ€ (1592) to Buffon's girl (1749) and the â€œWart Manâ€ of Tilesius (1793): antique illustrations of mosaicism in neurofibromatosis? Ruggieri, M.; Polizzi, A. // Journal of Medical Genetics;Mar2003, Vol. 40 Issue 3, p227
Examines antique illustrations of mosaicism in neurofibromatosis. Occurence of dominant disorders; Reflection of heterozygosity for a postzygotic mutation; Limitation of segmental lesions.
- Effect of Repeated Presentation on Sweetness Intensity of Binary and Ternary Mixtures of Sweeteners. Schiffman, Susan S.; Sattely-Miller, Elizabeth A.; Graham, Brevick G.; Zervakis, Jennifer; Butchko, Harriett H.; Stargel, W. Wayne // Chemical Senses;Mar2003, Vol. 28 Issue 3, p219
The purpose of the present study was to determine the effect of repeated presentation of the same sweet stimulus on sweetness intensity ratings. The sweet stimuli tested in this study were binary and ternary blends of 14 sweeteners that varied widely in chemical structure. A trained panel...
- The new sugar alternatives: are they safe? Broihier, Kitty // Shape;Feb2003, Vol. 22 Issue 6, p117
Presents information on artificial sweeteners and their health risks, if any. Form of availability, sweetness and uses of sweeteners Agave, Neotame, Stevia and Sucralose; Health concern owing to the use of Stevia.
- Your Brain on Bubbles. // Prevention;Jan2014, Vol. 66 Issue 1, p24
The article informs that according to a study published in the journal "Gastroenterology," brain regions in the drinkers of sugar-free and sugary sodas detect same sweetness, because of the carbon dioxide, which makes sugar and artificial sweeteners taste similar.
- Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings. Wada, Taizo; Konno, Akihiro; Schurman, Shepherd H.; Garabedian, Elizabeth K.; Anderson, Stacie M.; Kirby, Martha; Nelson, David L.; Candotti, Fabio // Journal of Clinical Investigation;5/1/2003, Vol. 111 Issue 9, p1389
Describes somatic mosaicism in two brothers affected with Wiskott-Aldrich syndromes (WAS). Original mutation causing disease in the family; Factor which abrogated the effects of the original mutation and restored the WAS protein reading frame; Evidence for potential beneficial outcomes of...
- Mosaicism for ATP2A2 Mutations Causes Segmental Darier's Disease. Sakuntabhai, Anavaj; Dhitavat, Jittima; Burge, Susan; Hovnanian, Alain // Journal of Investigative Dermatology;Dec2000, Vol. 115 Issue 6, p1144
Summary Epidermal naevi are localized malformations of the epidermis consisting of verrucoid scaly papules and plaques following Blaschko's lines. Genetic mosaicism has been proposed to underlie the development of linear epidermal naevi. Rarely, epidermal naevi show acantholytic histology...
- PAX2 mutations in renal—coloboma syndrome: mutational hotspot and germline mosaicism. Amiel, Jeanne; Audollent, Sophie; Joly, Dominique; Dureau, Pascal; Salomon, Rémi; Tellier, Anne-Lorraine; Augé, Joelle; Bouissou, François; Antignac, Corinne; Gubler, Marie-Claire; Eccles, Michel R; Munnich, Arnold; Vekemans, Michel; Lyonnet, Stanislas; Attié-Bitach, Tania // European Journal of Human Genetics;Nov2000, Vol. 8 Issue 11, p820
The renal-coloboma syndrome (RCS, MIM 120330) is an autosomal dominant disorder caused by PAX2 gene mutations. We screened the entire coding sequence of the PAX2 gene for mutations in nine patients with RCS. We found five heterozygous PAX2 gene mutations: a dinucleotide insertion (2G) at...
- Postzygotic mutation and germline mosaicism in the otopalatodigital syndrome spectrum disorders. Robertson, Stephen P; Thompson, Sarah; Morgan, Timothy; Holder-Espinasse, Muriel; Martinot-Duquenoy, Véronique; Wilkie, Andrew O M; Manouvrier-Hanu, Sylvie // European Journal of Human Genetics;May2006, Vol. 14 Issue 5, p549
The otopalatodigital syndrome (OPD) spectrum disorders are a heterogeneous group of skeletal dysplasias caused by mutations in the X-linked gene, FLNA. All OPD spectrum disorders (otopalatodigital syndromes types 1 and 2, frontometaphyseal dysplasia and Melnick-Needles syndrome) exhibit...