A master regulator of nociceptor differentiation

Markus, Annette
November 2008
Nature Neuroscience;Nov2008, Vol. 11 Issue 11, p1246
Academic Journal
The article discusses the study on the significance of the transcription factor Islet1 on sensory neuron development. It is noted that the authors genetically excised Islet1 from the early mouse neural crest and dorsal neural tube, where the dorsal root and trigeminal ganglia formed normally but from E12.5 onwards, most pain-and touch-sensitive neurons died. The results revealed that the proprioceptive cells had downregulated Islet1 by E14.5.


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