TITLE

Engineering and assaying of cytochrome P450 biocatalysts

AUTHOR(S)
Rabe, Kersten S.; Gandubert, Valérie J.; Spengler, Mark; Erkelenz, Michael; Niemeyer, Christof M.
PUB. DATE
November 2008
SOURCE
Analytical & Bioanalytical Chemistry;Nov2008, Vol. 392 Issue 6, p1059
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cytochrome P450s constitute a highly fascinating superfamily of enzymes which catalyze a broad range of reactions. They are essential for drug metabolism and promise industrial applications in biotechnology and biosensing. The constant search for cytochrome P450 enzymes with enhanced catalytic performances has generated a large body of research. This review will concentrate on two key aspects related to the identification and improvement of cytochrome P450 biocatalysts, namely the engineering and assaying of these enzymes. To this end, recent advances in cytochrome P450 development are reported and commonly used screening methods are surveyed.
ACCESSION #
34940178

 

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