TITLE

Association study of interleukin 2 ( IL2) and IL4 with schizophrenia in a Japanese population

AUTHOR(S)
Watanabe, Yuichiro; Nunokawa, Ayako; Shibuya, Masako; Kaneko, Naoshi; Nawa, Hiroyuki; Someya, Toshiyuki
PUB. DATE
October 2008
SOURCE
European Archives of Psychiatry & Clinical Neuroscience;Oct2008, Vol. 258 Issue 7, p422
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Interleukin 2 (IL-2) and IL-4 are pleiotropic cytokines regulating Th1/Th2 balance and have a regulatory activity in brain function. Thus these cytokines have been implicated in the pathophysiology of schizophrenia. The latest studies provided controversial results regarding the genetic associations of these cytokines. The functional polymorphisms, IL2-330T/G and IL4-590C/T, were associated with schizophrenia in a German population, although contradictory findings were also reported in a Korean population. To ascertain whether IL2 and IL4 contribute to vulnerability to schizophrenia, we conducted a moderate-scale case-control (536 patients and 510 controls) association study for seven polymorphisms in Japanese subjects. There were no significant associations of these genes with schizophrenia using either single marker or haplotype analyses. The present study suggests that IL2 and IL4 do not contribute to vulnerability to schizophrenia in the Japanese population.
ACCESSION #
34939868

 

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