TITLE

Crosstalk between small GTPases and polarity proteins in cell polarization

AUTHOR(S)
Iden, Sandra; Collard, John G.
PUB. DATE
November 2008
SOURCE
Nature Reviews Molecular Cell Biology;Nov2008, Vol. 9 Issue 11, p846
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to various diseases, including cancer. How cell polarity is established and how it is maintained remain fascinating questions. Conserved proteins of the partitioning defective (PAR), Scribble and Crumbs complexes guide the establishment of cell polarity in various organisms. Moreover, GTPases that regulate actin cytoskeletal dynamics have been implicated in cell polarization. Recent findings provide insights into polarization mechanisms and show intriguing crosstalk between small GTPases and members of polarity complexes in regulating cell polarization in different cellular contexts and cell types.
ACCESSION #
34883928

 

Related Articles

  • Cytoskeleton: Formin' filaments. Bussell, Katrin // Nature Reviews Molecular Cell Biology;Jul2002, Vol. 3 Issue 7, p470 

    Discusses research being done on the role of formins in actin-filament assembly. Reference to a study by D. Pruyne and colleagues, published in the June 6, 2002 issue of the journal "Science Express"; Domains of Bni1 formin; Analysis of the nucleating activity of formins; Findings on the...

  • Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton. Cui, Cheng; Chatterjee, Bishwanath; Lozito, Thomas P.; Zhang, Zhen; Francis, Richard J.; Yagi, Hisato; Swanhart, Lisa M.; Sanker, Subramaniam; Francis, Deanne; Yu, Qing; San Agustin, Jovenal T.; Puligilla, Chandrakala; Chatterjee, Tania; Tansey, Terry; Liu, Xiaoqin; Kelley, Matthew W.; Spiliotis, Elias T.; Kwiatkowski, Adam V.; Tuan, Rocky; Pazour, Gregory J. // PLoS Biology;Nov2013, Vol. 11 Issue 11, p1 

    Wdpcp, a protein required for both planar cell polarity and ciliogenesis, regulates cell polarity and alignment via direct modulation of the actin cytoskeleton.

  • Changes in the Apolar Organic Fraction Through The Composting Process. Grego, S.; Mezzetti, M.; Bucci, G.; Corradini, D.; Mincione, E. // Compost Science & Utilization;Spring2000, Vol. 8 Issue 2, p116 

    The organic fraction soluble in different organic solvents with increasing polarity was studied during the composting process, following its transformation from raw material until the stable final product with the aim to establish new quality indices of compost maturity. All apolar fractions...

  • Phosphatidylinositol 3-kinase activity and asymmetrical accumulation of F-actin are necessary for establishment of cell polarity in the early development of monospores from the marine red alga Porphyra yezoensis. Lin Li; Saga, Naotsune; Mikami, Koji // Journal of Experimental Botany;Oct2008, Vol. 59 Issue 13, p3575 

    The polarized distribution of F-actin is important in providing the driving force for directional migration in mammalian leukocytes and Dictyostelium cells, in which compartmentation of phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositol phosphatase is critical for the establishment of...

  • Beyond polymer polarity: how the cytoskeleton builds a polarized cell. Rong Li; Gundersen, Gregg G. // Nature Reviews Molecular Cell Biology;Nov2008, Vol. 9 Issue 11, p860 

    Cell polarity relies on the asymmetric organization of cellular components and structures. Actin and microtubules are well suited to provide the structural basis for cell polarization because of their inherent structural polarity along the polymer lattices and intrinsic dynamics that allow them...

  • Stretching Actin Filaments within Cells Enhances their Affinity for the Myosin II Motor Domain. Uyeda, Taro Q. P.; Iwadate, Yoshiaki; Umeki, Nobuhisa; Nagasaki, Akira; Yumura, Shigehiko // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    To test the hypothesis that the myosin II motor domain (S1) preferentially binds to specific subsets of actin filaments in vivo, we expressed GFP-fused S1 with mutations that enhanced its affinity for actin in Dictyostelium cells. Consistent with the hypothesis, the GFP-S1 mutants were localized...

  • Lipid rafts enriched in monosialylGb5Cer carrying the stage-specific embryonic antigen-4 epitope are involved in development of mouse preimplantation embryos at cleavage stage. Sato, Ban; Katagiri, Yohko U.; Miyado, Kenji; Okino, Nozomu; Ito, Makoto; Akutsu, Hidenori; Okita, Hajime; Umezawa, Akihiro; Fujimoto, Junichiro; Toshimori, Kiyotaka; Kiyokawa, Nobutaka // BMC Developmental Biology;2011, Vol. 11 Issue 1, p22 

    Background: Lipid rafts enriched in glycosphingolipids (GSLs), cholesterol and signaling molecules play an essential role not only for signal transduction started by ligand binding, but for intracellular events such as organization of actin, intracellular traffic and cell polarity, but their...

  • Surface polarity determination of wood fibres after different pretreatments and bisulphite pulping. Meincken, M.; Matyumza, N. C. // South African Journal of Science;Nov/Dec2008, Vol. 104 Issue 11/12, p453 

    THE SURFACE POLARITY OF PULP FIBRES originating from four different wood species commonly used for pulping in South Africa has been determined after various pre-treatments, and after magnesium bisulphite pulping. The presence as well as the distribution of polar groups on the fibre surface...

  • Human papillomaviruses, cervical cancer and cell polarity. Thomas, M; Narayan, N; Pim, D; Tomaić, V; Massimi, P; Nagasaka, K; Kranjec, C; Gammoh, N; Banks, L // Oncogene;11/24/2008, Vol. 27 Issue 55, p7018 

    Human papillomaviruses (HPVs) are the causative agents of a number of human cancers, of which cervical cancer is the most important. This occurs following persistent infection with a limited number of viral subtypes and is characterized by continued expression of the viral E6 and E7...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics