Turning anti-ageing genes against cancer

Longo, Valter D.; Lieber, Michael R.; Vijg, Jan
November 2008
Nature Reviews Molecular Cell Biology;Nov2008, Vol. 9 Issue 11, p903
Academic Journal
Recent studies in diverse organisms implicate proto-oncogenic pathways, including insulin-like growth factor-I (IGF-I), Ras and AKT/protein kinase B in the ageing process. Although IGF-I is thought to contribute to cancer by promoting growth and preventing apoptosis, evidence from model organisms suggests that proto-oncogene homologues might contribute to the DNA mutations and chromosomal damage that are observed in tumour cells by increasing DNA damage, in both dividing and non-dividing cells, and involving error-prone systems in DNA repair. This raises the possibility that cancer can be reduced by chronic downregulation of pro-ageing pathways.


Related Articles

  • Inhibition of Both EGFR and IGF1R Sensitized Prostate Cancer Cells to Radiation by Synergistic Suppression of DNA Homologous Recombination Repair. Wang, Yong; Yuan, Jian Lin; Zhang, Yun Tao; Ma, Jian Jun; Xu, Peng; Shi, Chang Hong; Zhang, Wei; Li, Yu Mei; Fu, Qiang; Zhu, Guang Feng; Xue, Wei; Lei, Yong Hua; Gao, Jing Yu; Wang, Juan Ying; Shao, Chen; Yi, Cheng Gang; Wang, He // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    Reduced sensitivity of prostate cancer (PC) cells to radiation therapy poses a significant challenge in the clinic. Activation of epidermal growth factor receptor (EGFR), type 1 insulin-like growth factor receptor (IGF1R), and crosstalk between these two signaling pathways have been implicated...

  • Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms. Schumacher, Björn; van der Pluijm, Ingrid; Moorhouse, Michael J.; Kosteas, Theodore; Robinson, Andria Rasile; Yousin Suh; Breit, Timo M.; van Steeg, Harry; Niedernhofer, Laura J.; van IJcken, Wilfred; Bartke, Andrzej; Spindler, Stephen R.; Hoeijmakers, Jan H. J.; van der Horst, Gijsbertus T. J.; Garinis, George A. // PLoS Genetics;Aug2008, Vol. 4 Issue 8, p1 

    Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the...

  • DNA double-strand break repair in Caenorhabditis elegans. Lemmens, Bennie; Tijsterman, Marcel // Chromosoma;Feb2011, Vol. 120 Issue 1, p1 

    Faithful repair of DNA double-strand breaks (DSBs) is vital for animal development, as inappropriate repair can cause gross chromosomal alterations that result in cellular dysfunction, ultimately leading to cancer, or cell death. Correct processing of DSBs is not only essential for maintaining...

  • Cetuximab Augments Cytotoxicity with Poly (ADPRibose) Polymerase Inhibition in Head and Neck Cancer. Nowsheen, Somaira; Bonner, James A.; LoBuglio, Albert F.; Trummell, Hoa; Whitley, Alexander C.; Dobelbower, Michael C.; Yang, Eddy S. // PLoS ONE;2011, Vol. 6 Issue 8, p1 

    Overexpression of the epidermal growth factor receptor (EGFR) is a hallmark of head and neck cancers and confers increased resistance and inferior survival rates. Despite targeted agents against EGFR, such as cetuximab (C225), almost half of treated patients fail this therapy, necessitating...

  • Higher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer. Klauke, Marie-Luise; Hoogerbrugge, Nicoline; Budczies, Jan; Bult, Peter; Prinzler, Judith; Radke, Cornelia; Krieken, J.; Dietel, Manfred; Denkert, Carsten; Müller, Berit // Virchows Archiv;Oct2012, Vol. 461 Issue 4, p425 

    Poly(ADP-ribose) polymerase 1 (PARP) is a key element of the single-base excision pathway for repair of DNA single-strand breaks. To compare the cytoplasmic and nuclear poly(ADP-ribose) expression between familial (BRCA1, BRCA2, or non BRCA1/2) and sporadic breast cancer, we investigated 39...

  • Novel Targeted Radiosensitisers in Cancer Treatment. Zaidi, Shane H.; Huddart, Robert A.; Harrington, Kevin J. // Current Drug Discovery Technologies;Jul2009, Vol. 6 Issue 2, p103 

    The last few years have seen a significant increase in our understanding of the molecular pathways governing cell function in cancer. This has led to an explosive interest in novel molecularly-targeted agents and, until recently, the focus of research effort has been to combine these agents with...

  • KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study. van Grieken, N C T; Aoyma, T; Chambers, P A; Bottomley, D; Ward, L C; Inam, I; Buffart, T E; Das, K; Lim, T; Pang, B; Zhang, S L; Tan, I B; Carvalho, B; Heideman, D A M; Miyagi, Y; Kameda, Y; Arai, T; Meijer, G A; Tsuburaya, A; Tan, P // British Journal of Cancer;4/16/2013, Vol. 108 Issue 7, p1495 

    Background:Inhibitors of the epidermal growth factor (EGFR) signaling pathway have a major role in the treatment of KRAS wild-type colorectal cancer patients. The EGFR pathway has been shown to be activated in gastric cancer (GC). However, published data on KRAS and BRAF mutation status is...

  • Brain metastases in gastro-oesophageal adenocarcinoma: insights into the role of the human epidermal growth factor receptor 2 (HER2). Feilchenfeldt, J; Varga, Z; Siano, M; Grabsch, H I; Held, U; Schuknecht, B; Trip, A; Hamaguchi, T; Gut, P; Balague, O; Khanfir, K; Diebold, J; Jochum, W; Shoji, H; Kushima, R; Wagner, D; Shimada, Y; Cats, A; Knuth, A; Moch, H // British Journal of Cancer;9/1/2015, Vol. 113 Issue 5, p716 

    Background:Gastro-oesophageal adenocarcinomas rarely metastasize to the central nervous system (CNS). The role of the human epidermal growth factor receptor 2 (HER2) in patients with these cancers and CNS involvement is presently unknown.Patients and Methods:A multicentre registry was...

  • Epidermal growth factor enhances cisplatin-induced apoptosis by a caspase 3 independent pathway. Cenni, Bruno; Aebi, Stefan; Nehmé, Alissar; Christen, Randolph D. // Cancer Chemotherapy & Pharmacology;May2001, Vol. 47 Issue 5, p397 

    Purpose: Activation of the epidermal growth factor (EGF) receptor has previously been shown to increase the sensitivity of cancer cells to DNA-damaging agents, including cisplatin, UV-B, and γ-radiation. We now investigated the mechanisms by which EGF enhances the sensitivity of human ovarian...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics