TITLE

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

AUTHOR(S)
Hochegger, Helfrid; Takeda, Shunichi; Hunt, Tim
PUB. DATE
November 2008
SOURCE
Nature Reviews Molecular Cell Biology;Nov2008, Vol. 9 Issue 11, p910
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a dominant-negative mutation of CDK1 blocks the cell cycle at G2–M phase, whereas dominant-negative CDK2 inhibits the transition into S phase, a model of cell-cycle control has emerged in which each transition is regulated by a specific subset of CDKs and cyclins. Recent work with gene-targeted mice has led to a revision of this model. We discuss cell-cycle control in light of overlapping and essential functions of the different CDKs and cyclins.
ACCESSION #
34883916

 

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