Chromatin remodeling: The interface between extrinsic cues and the genetic code?

Ezzat, Shereen
October 2008
Clinical & Investigative Medicine;Oct2008, Vol. 31 Issue 5, pE272
Academic Journal
The article presents several studies which illustrates the importance of epigenetics and its potential implications. A research focusing on the importance of Ikaros in hematopoietic stem cells. Another research examines the role of Ikaros in the anterior pituitary gland and in hypothalamus. The studies indicated that Ikaros can influence hypothalamic/pituitary cell development, differentiation, and offer evidence that these effects are mediated through overlapping and redundant.


Related Articles

  • Differentiation of Pluripotent Stem Cells into Hypothalamic and Pituitary Cells. Suga, Hidetaka // Neuroendocrinology;Apr2015, Vol. 101 Issue 1, p18 

    The hypothalamic-pituitary system is essential to maintain life and control systemic homeostasis, but it is negatively affected by various diseases, leading to serious symptoms. Embryonic stem (ES) cells differentiate into neuroectodermal progenitors when cultured as floating aggregates under...

  • A pituitary gland in a dish. Le Bot, Nathalie // Nature Cell Biology;Jan2012, Vol. 14 Issue 1, p50 

    The article offers information on the study conducted by Sasai and colleagues published in the 2011 issue of Nature regarding the embryonic stem cell-derived functional pituitary gland.

  • Workshop 3 O13-O18.  // International Journal of Obesity & Related Metabolic Disorders;May2001 Supplement, Vol. 25, pS7 

    Presents articles related to obesity published in the May 3, 2001 issue of the periodical 'International Journal of Obesity.' Effect of food ingestion selectivity on the activity of hypothalamic pituitary adrenal axis in obese women; Influence of exercise on hunger, appetite and energy balance...

  • Regenerative Medicine: Organ recital in a dish. Rizzoti, Karine; Lovell-Badge, Robin // Nature;12/1/2011, Vol. 480 Issue 7375, p44 

    The article focuses on a research, according to which pituitary gland regulates essential physiological processes, such as growth, puberty and reproduction. It mentions that the presumptive hypothalamus induces the formation of Rathke's pouch in the developing embryo and also regulates the...

  • Pharmacological Role of Oxytocin — A Short Review. kabilan, Anirudha // Journal of Pharmaceutical Sciences & Research;2014, Vol. 6 Issue 4, p220 

    Oxytocin is a hormone, predominately belonging to mammalian family; it is secreted by the posterior pituitary gland. After its release in the blood stream it cannot re-enter the brain due to the presence of blood brain barrier .Oxytocin is a hormone that has both peripheral and central actions...

  • Pituitary in a dish. Aschheim, Kathy // Nature Biotechnology;Jan2012, Vol. 30 Issue 1, p60 

    The article reports on a study which investigated how much intervention is required to coax embryonic stem cells to form complex organ structures, such as the pituitary gland, in vitro.

  • Basic Research Advances on Pituitary Stem Cell Function and Regulation. Russell, John P.; Lodge, Emily J.; Andoniadou, Cynthia L. // Neuroendocrinology;Sep2018, Vol. 107 Issue 2, p196 

    As a central regulator of major physiological processes, the pituitary gland is a highly dynamic organ, capable of responding to hormonal demand and hypothalamic influence, through adapting secretion as well as remodelling cell numbers among its seven populations of differentiated cells. Stem...

  • Regulatory System for Stem/Progenitor Cell Niches in the Adult Rodent Pituitary. Yoshida, Saishu; Kato, Takako; Kato, Yukio // International Journal of Molecular Sciences;2016, Vol. 17 Issue 1, p75 

    The anterior lobe of the pituitary gland is a master endocrine tissue composed of five types of endocrine cells. Although the turnover rate of pituitary endocrine cells is as low as about 1.6% per day, recent studies have demonstrated that Sex-determining region Y-box 2 (SOX2)+-cells exist as...

  • A piece in the puzzle of puberty. McCarthy, Margaret M // Nature Neuroscience;Mar2013, Vol. 16 Issue 3, p251 

    The article discusses research being done on the epigenetic repression of the onset of puberty in females. It reference a study by Lomniczi et al. published in the March 2013 issue of "Nature Neuroscience," which identified an increase in luteinizing hormone release from the anterior pituitary....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics