TITLE

N-terminal pro-B-type natriuretic peptide levels increases after hyperbaric oxygen therapy in diabetic patients

AUTHOR(S)
Yildiz, Senol; Uzun, Gunalp; Uz, Omer; Ipcioglu, Osman Metin; Kardesoglu, Ejder; Ozcan, Omer
PUB. DATE
October 2008
SOURCE
Clinical & Investigative Medicine;Oct2008, Vol. 31 Issue 5, pE231
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Diabetic patients receive hyperbaric oxygen therapy for non-healing lower extremity ulcers. Exposure to hyperbaric hyperoxia during hyperbaric oxygen therapy may affect cardiovascular functions by different mechanisms. Patients may experience serious problems such as pulmonary edema and death during hyperbaric oxygen therapy. The effect of hyperbaric oxygen therapy on cardiovascular functions in diabetic patients is not well documented. N-terminal pro-B-type natriuretic peptide (NTproBNP) has been suggested as powerful biochemical marker of cardiac function. The aim of this study was to investigate the effect of hyperbaric oxygen therapy on NTproBNP levels in diabetic patients. Methods: Twenty-five diabetic patients (19 male and 6 female, 64.7 ± 10.2 yr), who were planning to undergo hyperbaric oxygen therapy for non-healing lower extremity ulcers, were prospectively enrolled into the study. All patients were evaluated with echocardiography before the study. Heart rate and arterial blood pressure of patients were measured, and venous blood samples were drawn from each patient for NT-proBNP analysis before and immediately after the hyperbaric oxygen therapy. Results: NT-proBNP levels increased from 815 ± 1096 pg/ml to 915 ± 1191 pg/ml after HBO2 therapy (P<0.05). Heart rate and arterial blood pressure did not change with HBO2 therapy (P>0.05). Conclusion: Hyperbaric oxygen therapy induces considerable ventricular wall stress in diabetic patients. Care should be taken when a diabetic patient with cardiovascular disease is treated with hyperbaric oxygen therapy.
ACCESSION #
34879926

 

Related Articles

  • Acute pulmonary edema secondary to hyperbaric oxygen therapy. Obiagwu, Chukwudi; Paul, Vishesh; Chadha, Sameer; Hollander, Gerald; Shani, Jacob // Oxford Medical Case Reports;2015, Vol. 2015 Issue 2, p183 

    Hyperbaric oxygen therapy (HBOT) has been shown to be effective in the treatment of diabetic ulcers, air embolism, carbon monoxide poisoning and gas gangrene with minimal adverse effects. Very few cases of HBOT causing acute pulmonary edema (PE) has been described; with a study on dogs...

  • Lack of Effectiveness of Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcer and the Prevention of Amputation. MARGOLIS, DAVID J.; GUPTA, JAYANTA; HOFFSTAD, OLE; PAPDOPOULOS, MARYTE; GLICK, HENRY A.; THOM, STEPHEN R.; MITRA, NANDITA // Diabetes Care;Jul2013, Vol. 36 Issue 7, p1961 

    OBJECTIVE--Hyperbaric oxygen (HBO) is a device that is used to treat foot ulcers. The study goal was to compare the effectiveness of HBO with other conventional therapies administered in a wound care network for the treatment of a diabetic foot ulcer and prevention of lower-extremity amputation....

  • Point: Hyperbaric Oxygen Is Beneficial for Diabetic Foot Wounds. Barnes, Robert C. // Clinical Infectious Diseases;7/15/2006, Vol. 43 Issue 2, p188 

    The article discusses the evidence supporting the use of adjunctive hyperbaric oxygen therapy (HOT) in non-healing diabetic foot wounds. HOT is the intermittent administration of inhaled 100% oxygen while the subject is at an ambient pressure >1 atmosphere absolute. The adverse effects and cost...

  • Counterpoint: Hyperbaric Oxygen for Diabetic Foot Wounds Is Not Effective. Berendt, A. R. // Clinical Infectious Diseases;7/15/2006, Vol. 43 Issue 2, p193 

    Background. Diabetic foot ulceration is common, affecting 1.0%-4.1% of diabetic persons per year and up to 25% in a lifetime. Diabetic foot ulcers are multifactorial in origin, and many are slow to heal and/or are complicated by infection, frequently leading to amputation. Hyperbaric oxygen...

  • Does hyperbaric oxygenation therapy benefit in the treatment of non-healing wounds in diabetic patients? Novaleski, Carla // Internet Journal of Academic Physician Assistants;2009, Vol. 6 Issue 2, p4 

    As the incidence of diabetes mellitus type II is steadily increasing in our society, diabetic non-healing lower extremity wounds are complicating patient care. Hospitalization and amputation rates relating to diabetic lower extremity wounds are increasing causing concern relating to quality of...

  • Hyperbaric Oxygen Therapy in Patients with Chronic Wounds. Barry, Henry // American Family Physician;5/1/2005, Vol. 71 Issue 9, p1775 

    Discusses research being done on hyperbaric oxygen therapy in the management of patients with chronic wounds. Reference to a study by I. Roeckl-Wiedmann, et al, published in the January 2005 issue of the "British Journal of Surgery"; Varieties of chronic wounds which were evaluated; Reduction...

  • Fundamento científico de la oxígenoterapia hiperbárica en el tratamiento del pie diabético infectado grave en medicina basada en evidencias. Rodríguez, César L. Luna // Medicina Interna de Mexico;jul/ago2010, Vol. 26 Issue 4, p374 

    No abstract available.

  • Role of Hyperbaric Oxygen Therapy in Ischemic Diabetic Lower Extremity Ulcers: A Double-Blind Randomised-Controlled Trial. Marston, William A. // Perspectives in Vascular Surgery & Endovascular Therapy;Apr2004, Vol. 16 Issue 2, p141 

    The authors conducted a study to evaluate the rote of hyperbaric oxygen in the treatment of ischemic lower-extremity ulcers in patients with peripheral arterial disease. In patients with diabetes mellitus, these ulcers are associated with high risk of limb-threatening complications. Diabetic...

  • Can major amputation rates be decreased in diabetic foot ulcers with hyperbaric oxygen therapy? Kaya, Ahmet; Aydin, Figen; Altay, Taskin; Karapinar, Levent; Ozturk, Hasan; Karakuzu, Cengiz // International Orthopaedics;Apr2009, Vol. 33 Issue 2, p441 

    Although hyperbaric oxygen therapy has been used for diabetic foot ulcer since the 1980s, there is little information on its efficacy. The aim of this study is to evaluate whether hyperbaric oxygen can decrease major amputation rates and to determine the predictive factors. A total of 184...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics