Pulsed laser triggered high speed microfluidic switch

Wu, Ting-Hsiang; Gao, Lanyu; Chen, Yue; Wei, Kenneth; Chiou, Pei-Yu
October 2008
Applied Physics Letters;10/6/2008, Vol. 93 Issue 14, p144102
Academic Journal
We report a high-speed microfluidic switch capable of achieving a switching time of 10 μs. The switching mechanism is realized by exciting dynamic vapor bubbles with focused laser pulses in a microfluidic polydimethylsiloxane (PDMS) channel. The bubble expansion deforms the elastic PDMS channel wall and squeezes the adjacent sample channel to control its fluid and particle flows as captured by the time-resolved imaging system. A switching of polystyrene microspheres in a Y-shaped channel has also been demonstrated. This ultrafast laser triggered switching mechanism has the potential to advance the sorting speed of state-of-the-art microscale fluorescence activated cell sorting devices.


Related Articles

  • Laser switching and sorting for high speed digital microfluidics. de Saint Vincent, Matthieu Robert; Wunenburger, Régis; Delville, Jean-Pierre // Applied Physics Letters;4/14/2008, Vol. 92 Issue 15, p154105 

    We used thermocapillary stresses locally induced by laser on flowing drops to build high throughput drop switchers and sorters for digital microfluidics. Since the laser is disconnected to the chip, the method does not require dedicated micropatterning. We show switching efficiencies of 100% for...

  • An electrically tunable focusing liquid crystal lens with a built-in planar polymeric lens. Lin, Hung-Chun; Lin, Yi-Hsin // Applied Physics Letters;2/21/2011, Vol. 98 Issue 8, p083503 

    An electrically tunable focusing liquid crystal (LC) lens with a built-in planar polymeric lens with a short focal length (∼4.41 to 8.82 cm) is demonstrated. The focal length of the LC lens is contributed by two parts: one is the LC layer and the other is planar polymeric layer. In the...

  • Efficient switchless multi-Joule TE-CO2 laser. Bhadani, P. K.; Sylvan, A.; Harrison, R. G. // Review of Scientific Instruments;Jun91, Vol. 62 Issue 6, p1404 

    Switchless mode operation of a pulse TE-CO[sub 2] laser is reported. The system has provided an output energy of 7 J at atmospheric pressure from a discharge volume of 3 cm × 3.3 cm × 42 cm with an efficiency of 8%. Under long pulse loading, it has provided 3.5 J in a 5 μs pulse at an...

  • Lifetime-selective fluorescence imaging using an rf phase-sensitive camera. Lakowicz, Joseph R.; Berndt, Klaus W. // Review of Scientific Instruments;Jul1991, Vol. 62 Issue 7, p1727 

    We report the creation of two-dimensional fluorescence lifetime images, based on a sinusoidally modulated image intensifier that is operated as a radio-frequency phase-sensitive camera, synchronized to a mode-locked and cavity dumped picosecond dye laser. By combining the image intensifier with...

  • Low-frequency noise reduction in SQUID measurements using a laser-driven superconducting switch. Part B: Modulated inductance switching. Anderson, J. T.; Cabrera, B.; Taber, M. A. // Review of Scientific Instruments;Feb1989, Vol. 60 Issue 2, p209 

    We describe a technique for substantially decreasing the noise in SQUID measurement applications which are intrinsically low frequency or dc and thus fall below the 1/f knee in the SQUID noise energy spectrum. Direct switching of the SQUID input leads at a frequency above the 1/f knee, a...

  • Theoretical analysis of switching times in polarization switching lasers. Numai, Takahiro // Journal of Applied Physics;2/15/2000, Vol. 87 Issue 4, p1610 

    Presents a study which considered the switching characteristics of polarization switching lasers whose net gains for the two orthogonally polarized lights are electrically controlled. Factors that influenced the coupling strength of polarization switching lasers; Fundamentals of analysis;...

  • Multi-perspective scanning microscope based on Talbot effect. Yangyang Sun; Shuo Pang // Applied Physics Letters;2016, Vol. 108 Issue 2, p1 

    We report a multi-perspective scanning microscope based on the Talbot effect of a periodic focal spot array. Talbot illumination decouples the lateral scanning and the focal spots tuning. Large field of view fluorescence Talbot Microscope has been demonstrated by globally changing the incident...

  • Fluorescence nanoscopy by ground-state depletion and single-molecule return. Fölling, Jonas; Bossi, Mariano; Bock, Hannes; Medda, Rebecca; Wurm, Christian A.; Hein, Birka; Jakobs, Stefan; Eggeling, Christian; Hell, Stefan W. // Nature Methods;Nov2008, Vol. 5 Issue 11, p943 

    We introduce far-field fluorescence nanoscopy with ordinary fluorophores based on switching the majority of them to a metastable dark state, such as the triplet, and calculating the position of those left or those that spontaneously returned to the ground state. Continuous widefield illumination...

  • Two-color upconversion in rare-earth-ion-doped ZrO2 nanocrystals. Chen, G. Y.; Zhang, Y. G.; Somesfalean, G.; Zhang, Z. G.; Sun, Q.; Wang, F. P. // Applied Physics Letters;10/16/2006, Vol. 89 Issue 16, p163105 

    To develop fluorescent labels for multicolor imaging, rare-earth-ion-doped ZrO2 nanocrystals were prepared by a complex precursor method. Laser excitation of 976 nm induced single fluorescent bands of green and red upconversion (UC) in ZrO2:Er3+ and ZrO2:Er3++Yb3+ nanocrystals, respectively. A...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics