Mannose-Binding Lectin Concentrations, MBL2 Polymorphisms, and Susceptibility to Respiratory Tract Infections in Young Men

Rantala, Aino; Lajunen, Taina; Juvonen, Raija; Bloigu, Aini; Silvennoinen-Kassinen, Sylvi; Peitso, Ari; Saikku, Pekka; Vainio, Olli; Leinonen, Maija
October 2008
Journal of Infectious Diseases;10/15/2008, Vol. 198 Issue 8, p1247
Academic Journal
Background. Mannose-binding lectin (MBL) is an important component of innate immunity, and its deficiency is associated with susceptibility to recurrent infections. Methods. This exploratory study investigated the association of serum MBL concentrations and MBL2 gene polymorphisms with respiratory tract infections in young men. We genotyped 6 single-nucleotide polymorphisms (SNPs) in the promoter region (alleles H/L, X/Y, and P/Q) and exon 1 (variant alleles B, C, and D and wild-type allele A) of the MBL2 gene by real-time polymerase chain reaction and measured serum MBL concentrations in 111 Finnish military recruits with asthma and 362 without. Results. An MBL level below the median concentration was a significant risk factor for infections (asthma status- adjusted odds ratio [OR], 2.5 [95% confidence interval {CI}, 1.4-4.5]). Among the 6 SNPs, there was a significant association between the promoter Y/Y genotype and infections (OR, 2.3 [95% CI, 1.2- 4.4]) and a borderline significant association between exon 1 variant alleles and infections (OR, 1.7 [95% CI, 0.9 -3.1]), after adjustment for asthma status. Conclusion. These preliminary results suggest, for the first time, an association between MBL level and respiratory tract infections in young men and a possible association between infections and MBL2 polymorphisms.


Related Articles

  • Polymorphisms and Serum Level of Mannose-Binding Lectin: An Iranian Survey. Soltani, Ahmad; RahmatiRad, Sara; Pourpak, Zahra; Alizadeh, Zahra; Saghafi, Shiva; HajiBeigi, Bashir; Zeidi, Majid; Farazmand, Ali // Iranian Journal of Allergy, Asthma & Immunology;Dec2014, Vol. 13 Issue 6, p428 

    Mannose-binding lectin (MBL) is a Ca+2 -dependent collagenous lectin, that is produced by liver and mediates innate immune responses by opsonization of pathogens. The serum level of MBL varies widely among healthy individuals, ranging from 0.05&g/ml (or lower) to over 5&g/ml, mainly depending on...

  • Structural gene variants in the porcine mannose-binding lectin 1 (MBL1) gene are associated with low serum MBL-A concentrations. Juul-Madsen, Helle; Kjærup, Rikke; Toft, Charlotte; Henryon, Mark; Heegaard, Peter; Berg, Peer; Dalgaard, Tina // Immunogenetics;May2011, Vol. 63 Issue 5, p309 

    Mannose-binding lectin (MBL) is a collagenous lectin that kills a wide range of pathogenic microbes through complement activation. The MBL1 and MBL2 genes encode MBL-A and MBL-C, respectively. MBL deficiency in humans is associated with higher susceptibility to viral as well as bacterial...

  • The Association of SERPINE2 Gene with COPD in a Chinese Han Population. Aihua Wang; Yingqiu Yin; Ping Chen; Qiji Liu; Qinfeng Yu; Wei Xiao // Yonsei Medical Journal;11/1/2011, Vol. 52 Issue 6, p953 

    Purpose: Polymorphisms of several candidate genes have been studied and associated with the development of chronic obstructive pulmonary disease (COPD). One such candidate is the SERPINE2 (Serpin peptidase inhibitor, clade E member 2) gene. Materials and Methods: To assess whether the SERPINE2...

  • Toll-Like Receptor 2 Gene Polymorphisms Arg677Trp and Arg753Gln in Chronic Obstructive Pulmonary Disease. Pabst, Stefan; Yenice, Vildan; Lennarz, Martina; Tuleta, Izabela; Nickenig, Georg; Gillissen, Adrian; Grohé, Christian // Lung;May/Jun2009, Vol. 187 Issue 3, p173 

    Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, with a continually rising mortality rate. As COPD is driven by abnormal pulmonary and systemic inflammation, Toll-like receptors (TLRs) seem to be important. TLRs play a key role in innate response, and in...

  • Association study of genetic variants at single nucleotide polymorphism rs109231409 of mannose-binding lectins 1 gene with mastitis susceptibility in Vrindavani crossbred cattle. Muhasin Asaf, V. N.; Bhushan, Bharat; Panigrahi, Manjit; Dewangan, Prashant; Kumar, Amod; Kumar, Pushpendra; Gaur, G. K. // Veterinary World;Oct2014, Vol. 7 Issue 10, p807 

    Aim: The present study was undertaken to identify whether single nucleotide polymorphism (SNP) rs109231409 located on mannose-binding lectins 1 (MBL1) gene was associated with mastitis tolerance/susceptibility. Materials and Methods: After grouping 100 Vrindavani crossbred cattle as mastitis...

  • Variants in the Toll-Like Receptor Signaling Pathwayand Clinical Outcomes of Malaria. Leoratti, Fabiana M. S.; Farias, Lilian; Alves, Fabiana P.; Suarez-Mútis, Martha C.; Coura, José R.; Kalil, Jorge; Camargo, Erney P.; Moraes, Sandra L.; Ramasawmy, Rajendranath // Journal of Infectious Diseases;9/1/2008, Vol. 198 Issue 5, p772 

    Background. Malaria is one of the most significant infectious diseases in the world and is responsible for a large proportion of infant deaths. Toll-like receptors (TLRs), key components of innate immunity, are central to countering infection. Variants in the TLR-signaling pathway are associated...

  • CD14 C(-159)T Polymorphism Is a Risk Factor for Development of Pulmonary Tuberculosis. Rosas-Taraco, Adrian G.; Revol, Agnès; Salinas-Carmona, Mario C.; Rendon, Adrian; Caballero-Olin, Guillermo; Arce-Mendoza, Alma Y. // Journal of Infectious Diseases;12/1/2007, Vol. 196 Issue 11, p1698 

    Background. Neither the expression of CD14 and Toll-like receptor 4 (TLR4) on monocytes' surface nor the mutations CD14 -159TT and TLR4 Asp299Gly have yet been evaluated as risk factors for development of pulmonary tuberculosis (TB) in the Mexican population. Methods. Level of membrane CD14...

  • Association of macrophage migration inhibitory factor and mannose-binding lectin-2 gene polymorphisms in acute rheumatic fever. Col-Araz, Nilgun; Pehlivan, Sacide; Baspinar, Osman; Sever, Tugce; Oguzkan-Balci, Sibel; Balat, Ayse // Cardiology in the Young;Aug2013, Vol. 23 Issue 4, p486 

    BackgroundMacrophage migration inhibitory factor and mannose-binding lectin-2 play important roles in the pathogenesis of several acute and chronic inflammatory/autoimmune disorders. The aim of the study was to investigate any possible association between migration inhibitory factor and...

  • Chicken mannose-binding lectin ( MBL) gene variants with influence on MBL serum concentrations. Kjærup, Rikke; Norup, Liselotte; Skjødt, Karsten; Dalgaard, Tina; Juul-Madsen, Helle // Immunogenetics;Jun2013, Vol. 65 Issue 6, p461 

    Mannose-binding lectin (MBL) plays a major role in the innate immune defence by activating the lectin complement pathway or by acting as an opsonin. Two forms of MBL have been characterised from several species, but for humans and chickens, only one form of functional MBL has been described. The...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics