TITLE

Low Incidence of Anti-Osteoporosis Treatment After Hip Fracture

AUTHOR(S)
Rabenda, Véronique; Vanoverloop, Johan; Fabri, Valérie; Mertens, Raf; Sumkay, François; Vannecke, Carine; Deswaef, André; Verpooten, Gert A.; Reginster, Jean-Yves
PUB. DATE
October 2008
SOURCE
Journal of Bone & Joint Surgery, American Volume;Oct2008, Vol. 90-A Issue 10, p2142
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Following hip fracture, pharmacologic treatment can reduce the rate of subsequent fragility fractures. The objective of the present study was to assess the proportion of patients who are managed with bisphosphonates or selective estrogen-receptor modulators after hip fracture and to evaluate, among those managed with alendronate, the twelve-month compliance and persistence with treatment. Methods: Data were gathered from health insurance companies and were collected by AIM (Agence Intermutualiste) for the Belgian National Social Security Institute (INAMI). We selected all postmenopausal women who had been hospitalized for a hip fracture between April 2001 and June 2004 and had not been previously managed with bisphosphonates. Patients who had received alendronate treatment after the hip fracture were categorized according to their formulation use during the follow-up study (daily, weekly, daily followed by weekly, or weekly followed by weekly). Compliance at twelve months was quantified with use of the medication possession ratio (i.e.,the number of days of alendronate supplied during the first year of treatment, divided by 365). Persistence with prescribed treatment was calculated as the number of days from the initial prescription to a lapse of more than five weeks after completion of the previous prescription refill. The cumulative treatment persistence rate was determined with use of Kaplan-Meier survival curves. Results: A total of 23,146 patients who had sustained a hip fracture were identified. Of these patients, 6% received treatment during the study period: 4.6% received alendronate, 0.7% received risedronate, and 0.7% received raloxifene. Bisphosphonate treatment was dispensed to 2.6% and 3.6% of the patients within six months and one year after the occurrence of the hip fracture, respectively. Amongwomen who received alendronate daily (n = 124) orweekly(n = 182) and were followed forat least one yearafterthe hip fracture, the twelve-month mean medication possession ratio was 67% (65.9% in the daily group and 67.7% in the weekly group). The analysis of persistence with treatment included a total of 726 patients (142 in the daily group, 261 in the weekly group, and 323 in the switch group). At twelve months, the rate of persistence was 41% and the median duration of persistence was 40.3 weeks. Conclusions: The vast majority of patients who experience a hip fracture do not take anti-osteoporotic therapy after the fracture. Furthermore, among patients who begin alendronate treatment after the fracture, the adherence to treatment decreases overtime and remains suboptimal.
ACCESSION #
34775830

 

Related Articles

  • Crutches in Cushing's disease. Davies, M. B.; Scott, I. R.; Babu, V. V. Suresh // Journal of the Royal Society of Medicine;Jul2001, Vol. 94 Issue 7, p348 

    The article discusses the medical case of a 25-year-old woman who reported pain in her shoulder after using crutches for six months. Before using crutches, the woman was diagnosed with hip fracture and was treated with dynamic hip screw and plate fixation. The pain had been present at the time...

  • Operative treatment of the ischial tuberosity avulsion fracture - a case report.  // Arthroscopy & Joint Surgery;Jul2010, Vol. 6 Issue 3/4, p24 

    The article presents a clinical case report where the avulsion fracture of ischial tuberosity was surgically treated. It is mentioned that most common treatment procedures have been non-surgical but after these treatments few patients have been able to move back to sports. The case discusses an...

  • A retrospective analysis of bilateral fractures over sixteen years: localisation and variation in treatment of second hip fractures. Kok, Laura; Steenhoven, Tim; Nelissen, Rob // International Orthopaedics;Oct2011, Vol. 35 Issue 10, p1545 

    The aim of this study was the evaluation of contralateral hip fractures after a previous hip fracture. For this retrospective analysis patients were selected from the database of the LUMC, a teaching hospital in the south-west of the Netherlands. We analyzed all patients with a second fracture...

  • Surgery for hip fractures: Does surgical delay affect outcomes? Simunovic, Nicole; Devereaux, P. J.; Bhandari, Mohit // Indian Journal of Orthopaedics;Jan-Mar2011, Vol. 45 Issue 1, p27 

    Hip fractures are associated with a high rate of mortality and profound temporary and sometimes permanent impairment of quality of life. Current guidelines indicate that surgeons should perform surgery for a hip fracture within 24 hours of injury because earlier surgery is associated with better...

  • OSTEOPOROTIC PERTROCHANTERIC FRACTURES CAN BE SUCCESSFULLY TREATED WITH EXTERNAL FIXATION. Moroni, Antonio; Faldini, Cesare; Pegreffi, Francesco; Hoang-Kim, Amy; Giannini, Sandro // Journal of Bone & Joint Surgery, American Volume;Dec2005 Supplement 2, Vol. 87-A, p42 

    The article presents information related to treatment of hip fractures. Hip fractures are the most severe of all fragility fractures. It has been calculated that more deaths are caused by hip fractures than by other common severe diseases such as cancer of the stomach or the pancreas. The most...

  • Treating intertrochanteric hip fractures: Nails or plates? Leahy, Maureen // AAOS Now;Jan2011, Vol. 5 Issue 1, p18 

    The article focuses on the difference in the outcomes of patients with intertrochanteric hip fractures treated with Intramedullary (IM) nails or plate fixation. It states that patients treated with IM nails were found to have higher risks of having pulmonary embolism (PE) and mortality at 90...

  • Osteoporosis drug can prevent broken hips.  // Brown University Long-Term Care Quality Advisor;7/15/96, Vol. 8 Issue 13, p8 

    Reports on a study which indicated that the new bone-building drug known as alendronate can cut the hip fracture rate in some high-risk, post-menopausal women by about 50 percent. Fewer spinal and wrist fractures in women taking the drug for three years; Costs of treating each fracture;...

  • Comment on: "Outcome of short proximal femoral nail antirotation and dynamic hip screw for fixation of unstable trochanteric fractures. A randomised prospective comparative trial". Fang-Jie Zhang; Guang-Hua Lei // Hip International;Apr-Jun2012, Vol. 22 Issue 2, p234 

    A letter to the editor is presented in response to the article "Outcome of Short Proximal Femoral Nail Antirotation and Dynamic Hip Screw for Fixation of Unstable Trochanteric Fractures. A Randomised Prospective Comparative Trial” by Garg et al., which appeared in a 2011 issue.

  • Use of the Schanz screw as a joystick and the Poller screw in intramedullary nailing for subtrochanteric or proximal femoral fracture. Chen, Chun-Yu; Lin, Kai-Cheng; Yang, Shan-Wei; Tarng, Yih-Wen; Hsu, Chien-Jen; Renn, Jenn-Huei // European Journal of Orthopaedic Surgery & Traumatology;Feb2013, Vol. 23 Issue 2, p241 

    A letter to the editor is presented in response to the article "Use of Blocking Screws in Intramedullary Fixation of Subtrochanteric Fractures’’ by N. Amin et al.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics