Ionometric determination of cefotaxime in biological media

Kulapina, O.; Baraguzina, V.; Skoblikova, N.
March 2008
Pharmaceutical Chemistry Journal;Mar2008, Vol. 42 Issue 3, p150
Academic Journal
Ion-selective electrodes based on ion exchangers of tetradecylammonium (TDA) with cefotaxime (claforan) anions have been developed. The proposed electrodes are sensitive to cephalosporins in the concentration range from 1 × 10− 5 to 1 × 10− 1 M. The time for establishing a steady-state potential is 1–2 min. The potential drift does not exceed 2 mV/d. The detection threshold for cefotaxime is 3.6 × 10− 5 M in the optimum pH range of 4.3–6.5. Comparison of the main electrochemical characteristics of the ion-selective electrodes based on TDA associates with cephalosporins showed that the best parameters are found in electrodes with membranes containing claforan.


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