TITLE

Heat shock proteins 27 and 70 regulating angiotensin II-induced NF-κB: a possible connection to blood pressure control?

AUTHOR(S)
Voegeli, Tracy S.; Wintink, Amanda J.; Chen, Yu; Currie, R. William
PUB. DATE
October 2008
SOURCE
Applied Physiology, Nutrition & Metabolism;Oct2008, Vol. 33 Issue 5, p1042
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Heat shock proteins (HSPs) are critical for cell survival and have several mechanisms of action. HSPs regulate protein folding, suppress apoptosis, and regulate anti-oxidative activity. In addition, HSPs are involved in the regulation of the pro-inflammatory transcription factor nuclear factor (NF)-κB. When angiotensin (Ang) II is infused into rats, there is a significant increase in systolic blood pressure, and NF-κB is activated in the heart. If rats are heat shocked to induce the heat shock response and HSPs before Ang II infusion, there is a significant suppression of both the Ang II-induced increase in blood pressure and NF-κB activation in the heart. Although the role of specific HSPs in the regulation of NF-κB is unclear, several HSPs, including Hsp27 and Hsp70, are thought to be involved in the regulation of Ang II-induced NF-κB. The role of Hsp27 and Hsp70 in NF-κB activation is reviewed here, along with evidence suggesting that HSPs regulate Ang II-induced blood pressure through the regulation of NF-κB.
ACCESSION #
34716328

 

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