Heat shock proteins 27 and 70 regulating angiotensin II-induced NF-κB: a possible connection to blood pressure control?

Voegeli, Tracy S.; Wintink, Amanda J.; Chen, Yu; Currie, R. William
October 2008
Applied Physiology, Nutrition & Metabolism;Oct2008, Vol. 33 Issue 5, p1042
Academic Journal
Heat shock proteins (HSPs) are critical for cell survival and have several mechanisms of action. HSPs regulate protein folding, suppress apoptosis, and regulate anti-oxidative activity. In addition, HSPs are involved in the regulation of the pro-inflammatory transcription factor nuclear factor (NF)-κB. When angiotensin (Ang) II is infused into rats, there is a significant increase in systolic blood pressure, and NF-κB is activated in the heart. If rats are heat shocked to induce the heat shock response and HSPs before Ang II infusion, there is a significant suppression of both the Ang II-induced increase in blood pressure and NF-κB activation in the heart. Although the role of specific HSPs in the regulation of NF-κB is unclear, several HSPs, including Hsp27 and Hsp70, are thought to be involved in the regulation of Ang II-induced NF-κB. The role of Hsp27 and Hsp70 in NF-κB activation is reviewed here, along with evidence suggesting that HSPs regulate Ang II-induced blood pressure through the regulation of NF-κB.


Related Articles

  • PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms. Deres, Laszlo; Bartha, Eva; Palfi, Anita; Eros, Krisztian; Riba, Adam; Lantos, Janos; Kalai, Tamas; Hideg, Kalman; Sumegi, Balazs; Gallyas, Ferenc; Toth, Kalman; Halmosi, Robert // PLoS ONE;Jul2014, Vol. 9 Issue 7, p1 

    Spontaneously hypertensive rat (SHR) is a suitable model for studies of the complications of hypertension. It is known that activation of poly(ADP-ribose) polymerase enzyme (PARP) plays an important role in the development of postinfarction as well as long-term hypertension induced heart...

  • The Role of HSPA12B in Regulating Neuronal Apoptosis. Kang, Lihua; Zhang, Guowei; Yan, Yaohua; Ke, Kaifu; Wu, Xinmin; Gao, Yilu; Li, Jing; Zhu, Lin; Wu, Qiyun; Zhou, Zhengming // Neurochemical Research;Feb2013, Vol. 38 Issue 2, p311 

    Heat shock protein A12B (HSPA12B) is the newest member of a recently defined subfamily of proteins distantly related to the 70-kDa family of heat shock proteins (HSP70) family. HSP70s play a crucial role in protecting cells, tissues, organs and animals from various noxious conditions. Here we...

  • Effect of Cell Transplantation on Induction of Heat Shock Proteins in Damaged Heart. B. Baduev; G. Borovskii; V. Voinikov; S. Golubev; I. Babushcina; T. Kurilskaya; Yu. Pivovarov // Bulletin of Experimental Biology & Medicine;Jul2009, Vol. 148 Issue 1, p132 

    Variations in the amount of heat shock proteins of various classes in the damaged myocardium of rats were studied after xenogeneic transplantation of heart cells.

  • Localization and Expression of Hsp27 and αB-Crystallin in Rat Primary Myocardial Cells during Heat Stress In Vitro. Tang, Shu; Buriro, Rehana; Liu, Zhijun; Zhang, Miao; Ali, Islam; Adam, Abdelnasir; Hartung, Jörg; Bao, Endong // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Neonatal rat primary myocardial cells were subjected to heat stress in vitro, as a model for investigating the distribution and expression of Hsp27 and αB-crystallin. After exposure to heat stress at 42°C for different durations, the activities of enzymes expressed during cell damage...

  • Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein Inhibits Angiotensin II-Induced Cardiac Remodeling. Yang, Kun; Zhang, Tian-Peng; Tian, Cui; Jia, Li-xin; Du, Jie; Li, Hui-Hua // American Journal of Hypertension;Sep2012, Vol. 25 Issue 9, p994 

    BackgroundThe carboxyl terminus of heat shock protein 70-interacting protein (CHIP), an E3 ligase/chaperone, was found to protect cardiomyocytes against apoptosis induced by ischemic injury; however, the functional role of CHIP in remodeling induced by angiotensin II (Ang II) remains...

  • P53 pseudogene: potential role in heat shock induced apoptosis in a rat histiocytoma. Sreedhar, Amere Subbarao // Health (1949-4998);Sep2010, Vol. 2 Issue 9, p1065 

    The p53 tumor suppressor gene is either nonfunctional or highly and frequently mutated in majority of cancers. In our study towards understanding cellular adaptations to stress using a rat histiocytic tumor model, we have identified mis-sense mutation in p53 that led to premature termination of...

  • Favorable cardiac and aortic remodeling in olmesartan-treated spontaneously hypertensive rats. Fernandes-Santos, Caroline; Souza Mendonça, Leonardo; Mandarim-de-Lacerda, Carlos // Heart & Vessels;May2009, Vol. 24 Issue 3, p219 

    Cardiovascular remodeling contributes to the progression of cardiovascular disease. Thus, our aim was to evaluate the action of long-term treatment with olmesartan on cardiac and aortic adverse remodeling and its relationship with blood pressure (BP) and tensile forces acting on the aortic wall....

  • Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation. Yu Duan; Xin Zhao; Wei Ren; Xin Wang; Ke-Fu Yu; Dan Li; Xuan Zhang; Qiang Zhang // OncoTargets & Therapy;2013, Vol. 6, p189 

    Dichloroacetate (DCA), a small molecule mitochondria-targeting agent, can penetrate the blood--brain barrier, showing potential therapeutic effects on brain tumors. Considering the effects of DCA on tumor cellular metabolism, penetrating across the blood--brain barrier, as well as having...

  • Regulatory effect of heat shock protein 70 in stress-induced rat intestinal epithelial barrier dysfunction. Ping-Chang Yang; Ya-Hong Tu; Perdue, Mary H.; Oluwol, Christine; Struiksma, Stevie // North American Journal of Medical Sciences;Jun2009, Vol. 1 Issue 1, p9 

    Background: Psychological stress is one of the factors associated with many human diseases; the mechanisms need to be further understood. Methods: Rats were subjected to chronic water avoid stress. Intestinal epithelial heat shock protein (HSP) 70 was evaluated. The intestinal epithelial...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics