Clinical implication and prognostic significance of standardised uptake value of primary non-small cell lung cancer on positron emission tomography: analysis of 176 cases

Al-Sarraf, Nael; Gately, Kathy; Lucey, Julie; Aziz, Rashid; Doddakula, Kishore; Wilson, Lorraine; McGovern, Eillish; Young, Vincent
October 2008
European Journal of Cardio-Thoracic Surgery;Oct2008, Vol. 34 Issue 4, p892
Academic Journal
Abstract: Objective: We sought to assess the clinical implication and prognostic significance of maximum standardised uptake value (SUVmax) of primary non-small cell lung cancer (NSCLC) staged by integrated PET-CT. Methods: A retrospective review was carried out on 176 consecutive patients with histologically proven NSCLC who underwent staging with integrated PET-CT prior to curative intent surgical resection. SUVmax of primary NSCLC were measured and correlated with tumour characteristics, lymph node involvement, surgical stage, type of surgical resection and survival following resection. Results: SUVmax was significantly higher in centrally located tumours, tumours ≥4.0cm, squamous cell subtype, poorly differentiated tumours, advanced T stage, advanced nodal stage, pleural invasion, and patients requiring complex surgical resection. SUVmax value of 15 was the best discriminative cut-off value for survival generated by log-rank test. When patients were stratified based on this value, those with SUVmax >15 were more likely to have centrally located tumours, squamous cell subtype, advanced T stage, advanced nodal stage, advanced American Joint Committee on Cancer (AJCC) stage, larger tumour size and required more advanced surgical resections than a simple lobectomy. Overall survival was significantly longer for patients with SUVmax ≤15 than those with SUVmax >15. Furthermore, nodal stage specific survival following resection (i.e. non-N2 and N2) were significantly better in patients with SUVmax ≤15 than SUVmax >15. Conclusion: SUVmax correlates with tumour characteristics, surgical stage and prognosis following resection. SUVmax may be a useful preoperative tool, in addition to other known prognostic markers, in allocating patients with potentially poor prognosis preoperatively to neoadjuvant chemotherapy prior to resection in order to improve their overall survival. Prospective and randomised trials are warranted.


Related Articles

  • Limited resection for clinical Stage IA non-small-cell lung cancers based on a standardized-uptake value index†. Shiono, Satoshi; Abiko, Masami; Sato, Toru // European Journal of Cardio-Thoracic Surgery;Jan2013, Vol. 43 Issue 1, pe7 

    OBJECTIVES In a previous study, we found that a standardized-uptake value (SUV) index obtained from positron emission tomography (PET)/computed tomography (CT) data was significantly correlated with prognosis in patients with pathological Stage I lung adenocarcinoma. However, this value has not...

  • Detecting Spread of Non--Small-Cell Lung Cancer within the Chest.  // Annals of Internal Medicine;12/2/2003, Vol. 139 Issue 11, pI-18 

    Presents the results of a study on the detection of the spread of non-small-cell lung cancer within the chest. Prevalence of cancer; Comparison of the accuracy of computed tomography and positron emission tomography scans for detection; Number of participants in the study; Procedures for the...

  • Prognostic factors in patients undergoing complete resection of pulmonary metastases of colorectal cancer: a multi-institutional cumulative follow-up study. Hirosawa, Tomoichiro; Itabashi, Michio; Ohnuki, Takamasa; Yamaguchi, Naohito; Sugihara, Kenichi; Kameoka, Shingo // Surgery Today;May2013, Vol. 43 Issue 5, p494 

    Purpose: The aim of this retrospective study was to establish the prognostic factors for overall survival after pulmonary resection for lung metastases of colorectal carcinoma (CRC). Methods: The baseline characteristics and outcomes of 266 CRC patients undergoing complete pulmonary resection...

  • Whole-body metabolic tumour volume of F-FDG PET/CT improves the prediction of prognosis in small cell lung cancer. Oh, Jong-Ryool; Seo, Ji-Hyoung; Chong, Ari; Min, Jung-Joon; Song, Ho-Chun; Kim, Young-Chul; Bom, Hee-Seung // European Journal of Nuclear Medicine & Molecular Imaging;Jun2012, Vol. 39 Issue 6, p925 

    Purpose: We investigated whether the whole-body metabolic tumour volume (WBMTV) measured by F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can improve the prediction of prognosis in patients with small cell lung cancer (SCLC). Methods: We reviewed 106...

  • FDG-PET appears promising for predicting prognosis of patients with inoperable NSCLC.  // Biomedical Market Newsletter;10/10/2011, Vol. 21, p286 

    The article reports that F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) scans seems to be a promising tool for predicting the prognosis of nonsmall cell lung cancer (NSCLC) patients.

  • Role of surgical resection in colorectal lung metastases: analysis of 137 patients. Borasio, Piero; Gisabella, Mara; Billé, Andrea; Righi, Luisella; Longo, Marina; Tampellini, Marco; Ardissone, Francesco // International Journal of Colorectal Disease;Feb2011, Vol. 26 Issue 2, p183 

    Purpose: The aim of this study is to investigate clinicopathologic characteristics and to identify prognostic factors in patients undergoing pulmonary metastasectomy for colorectal carcinoma. Methods: This study is a single-institution retrospective study of 137 consecutive patients who...

  • Clinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer. Yilmaz, Aydin; Duyar, Sezgi Sahin; Cakir, Ebru; Aydin, Ertan; Demirag, Funda; Karakaya, Jale; Yazici, Ulku; Erdogan, Yurdanur // European Journal of Cardio-Thoracic Surgery;Sep2011, Vol. 40 Issue 3, p664 

    Abstract: Objectives: This study is conducted to show the relationship between visceral pleural, lymphovascular, and perineural invasion, and other clinicopathologic characteristics and their significance as prognostic factors. Methods: The clinicopathologic characteristics of 289 patients who...

  • Growth patterns of lung metastases from sarcomas. Welter, Stefan; Grabellus, Florian; Bauer, Sebastian; Schmid, Kurt; Stamatis, Georgios; Tötsch, Martin; Schmid, Kurt Werner; Tötsch, Martin // Virchows Archiv;Aug2011, Vol. 459 Issue 2, p213 

    Complete resection of pulmonary metastases from sarcomas is an established method of treatment. While resection margins are well described for primary sarcoma lesions, minimal knowledge is available about margins and factors influencing local tumour control in the lung. The objective of the...

  • Role of positron emission tomography in mediastinal lymphatic staging of non-small cell lung cancer. Melek, Huseyin; Gunluoglu, Mehmet Zeki; Demir, Adalet; Akin, Hasan; Olcmen, Aysun; Dincer, Seyyit Ibrahim // European Journal of Cardio-Thoracic Surgery;Feb2008, Vol. 33 Issue 2, p294 

    Abstract: Objective: Positron emission tomography (PET) is used increasingly in staging of non-small cell lung cancer (NSCLC) as a non-invasive tool. The role of the PET in mediastinal lymphatic staging of NSCLC is not clear. We aimed to demonstrate the efficacy of PET in determining mediastinal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics