TITLE

Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano--Monghidoro study

AUTHOR(S)
Zagari, R. M.; Fuccio, L.; Wallander, M.-A.; Johansson, S.; Fiocca, R.; Casanova, S.; Farahmand, B. Y.; Winchester, C. C.; Roda, E.; Bazzoli, F.
PUB. DATE
October 2008
SOURCE
Gut;Oct2008, Vol. 57 Issue 10, p1354
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Existing endoscopy-based data on gastro-oesophageal reflux disease (GOAD) in the general population are scarce. This study aimed to evaluate typical symptoms and complications of GOAD, and their associated risk factors, in a representative sample of the Italian population. Methods: 1533 adults from two Italian villages were approached to undergo symptom assessment using a validated questionnaire and upper gastrointestinal endoscopy. Data were obtained from 1033 individuals (67.4% response rate). Results: The prevalence of reflux symptoms was 44.3%; 23.7% of the population experienced such symptoms on at least 2 days per week (frequent symptoms). The prevalence rates of oesophagitis and Barrett's oesophagus in the population were 11.8% and 1.3%, respectively. Both frequent (relative risk (AR) 2.6; 95% confidence interval (Cl) 1.7 to 3.9) and infrequent (AR 1.9; 95% Cl 1.2 to 3.0) reflux symptoms were associated with the presence of oesophagitis. No reflux symptoms were reported by 32.8% of individuals with oesophagitis and 46.2% of those with Barrett's oesophagus. Hiatus hernia was associated with frequent reflux symptoms and oesophagitis, and was present in 76.9% of those with Barrett's oesophagus. We found no association between body mass index and ref lux symptoms or oesophagitis. Conclusions: GOAD is common in Italy, but the prevalence of Barrett's oesophagus in the community is lower than has been reported in selected populations. Both frequent and infrequent reflux symptoms are associated with an increased risk of oesophagitis. Individuals with oesophagitis and Barrett's oesophagus often have no reflux symptoms.
ACCESSION #
34640814

 

Related Articles

  • Correlation of the gastroesophageal flap valve grade with the surgery rate in patients with gastroesophageal reflux disease. Kayaoglu, Huseyin // Surgical Endoscopy;Mar2013, Vol. 27 Issue 3, p801 

    Background: The importance of endoscopic evaluation and grading of the gastroesophageal flap valve (GEFV) in patients with gastroesophageal reflux disease (GERD) was previously demonstrated with increased acid exposure and high grades of esophagitis in those with high-grade valves. On the other...

  • Recent advances in oesophageal diseases. Dulaimi, David Al // Gastroenterology & Hepatology from Bed to Bench;Summer2014, Vol. 7 Issue 3, p186 

    The article presents several studies related to oesophageal diseases which was published in various science periodical including Clinical Endoscopy, World Journal of Gastroenterology and Clinical Endoscopy as of July 2014. Topics discussed include Barrett esophagus disease in Asia, gender and...

  • DOES THE LENGTH OF BARRETT'S OESOPHAGUS HAVE AN IMPACT ON CLINICAL PRACTICE? Arebi, N.; Pouzey, A.; Beveridge, I. // Gut;Apr2004 Supplement 3, Vol. 53, pA62 

    The article presents a study to see if the length of Barrett's oesophagus (BO) has an impact on clinical practice. There is widespread variation in clinical practice for managing BO and for surveillance in relation to the length of BO. The development of BO has been linked to gastro-oesophageal...

  • Gastro-oesophageal reflux disease. Warren, Ed // Update;10/20/2005, Vol. 71 Issue 4, p16 

    This article focuses on the gastro-oesophageal reflux disease (GORD) and its treatment. The term GORD, defined by Great Britain guidelines, is one used to describe diseases that cause reflux of gastric contents into the oesophagus, causing symptoms show no endoscopic signs of oesophageal damage....

  • Impact of hiatal hernia on histological pattern of non-erosive reflux disease. Gatopoulou, Anthie; Mimidis, Konstantinos; Giatromanolaki, Alexandra; Papadopoulos, Vassilios; Polychronidis, Alexandros; Lyratzopoulos, Nikolaos; Sivridis, Efthimios; Minopoulos, Georgios // BMC Gastroenterology;2005, Vol. 5, p2 

    Background: Hiatus hernia (HH) has major pathophysiological effects favoring gastroesophageal reflux and hence contributing to esophageal mucosa injury, especially in patients with severe gastroesophageal disease. However, prospective studies investigating the impact of HH on the esophageal...

  • Barrett's Esophagus: Prevalence and Size of Hiatal Hernia. Cameron, Alan J. // American Journal of Gastroenterology;Aug1999, Vol. 94 Issue 8, p2054 

    OBJECTIVE: Barrett's esophagus is caused by gastroesophageal reflux and predisposes to adenocarcinoma. Hiatal hernia may cause reflux. The prevalence and size of hernias in patients with Barrett's esophagus was investigated. METHODS: Axial hernia length and the width of the diaphragmatic hiatus...

  • Correlation Between Helicobacter pylori, Hiatal Hernia and Barrett's Esophagus. Melania, Macarie; Simona, Băţagă; Daniela, Crosnoi; Macarie, I.; Imola, Török; Georgescu, D.; Silvia, Sârbu-Pop // Acta Medica Marisiensis;Jan2011, Vol. 57 Issue 1, p31 

    Background: The incidence of adenocarcinoma of the esophagus has dramatically increased during the last 2 decades and so has the incidence of Barrett's esophagus, one of the most important risk factors for esophageal adenocarcinoma. Aim: The aim of this study was to determine whether infection...

  • Radiofrequency Ablation of Barrett’s Esophagus. Watson, Thomas J. // Journal of Gastrointestinal Surgery;Feb2010 Supplement 1, Vol. 14, p88 

    Barrett’s esophagus (BE) is known to be due to chronic gastroesophageal reflux disease and is a precursor of esophageal adenocarcinoma. The ability to eliminate BE is appealing, given the neoplastic potential of this condition and the continued increase in incidence of adenocarcinoma...

  • Collis-Nissen fundoplication for a symptomatic paraesophageal hernia. Racette, Ashley L.; Miller, Richard T. // JAAPA: Journal of the American Academy of Physician Assistants (;Jul2010, Vol. 23 Issue 7, p28 

    The article presents a case of 64-year-old female with a long history of gastroesophageal reflux disease (GERD), diagnosed with a large paraesophageal hernia after undergoing computer tomography (CT) scan. The patient complained mainly of early satiety, regurgitation of food, and some epigastric...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics