Beyond TNF, Th1 and Th2 in inflammatory bowel disease

Shale, Matthew; Ghosh, Subrata
October 2008
Gut;Oct2008, Vol. 57 Issue 10, p1349
Academic Journal
The article focuses on the widespread use of a therapy utilizing antitumour necrosis factor (TNF) monoclonal antibodies for the treatment of Crohn's disease (CD) and ulcerative colitis (UC). It states that other therapies with anticytokines ability are in development, including against interleukin 6 (IL6), IL12/23 and interferon. It cites that targeting cytokines is based from observations regarding cytokine profile in the tissues of the intestine of patients with inflammatory bowel disease.


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