Heterogeneity of regional systolic function detected by tissue Doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy

Kato, T. S.; Izawa, H.; Komamura, K.; Noda, A.; Asano, H.; Nagata, K.; Hashimoto, S.; Oda, N.; Kamiya, C.; Kanzaki, H.; Hashimura, K.; Ueda, H. I.; Murohara, T.; Kitakaze, M.; Yokota, M.
October 2008
Heart;Oct2008, Vol. 94 Issue 10, p1302
Academic Journal
Objective: To evaluate regional and global left ventricular (LV) function and LV wall thickness (LVVVT) in patients with hypertrophic cardiomyopathy (HCM). Design and setting: Observational study at the National Cardiovascular Centre and Nagoya University Hospital in Japan. Participants: Thirty-six patients with HCM and 16 patients with hypertensive LV hypertrophy (LVH). Main outcome measures: Conventional echocardiography and strain rate (SR) imaging derived from tissue Doppler imaging were performed. Systolic strain (ϵ[subsys]) peak systolic SR (SR[subsys), peak early diastolic SR (SR[subdia]) and LW\/T were obtained from eight LV segments. LV pressure was simultaneously recorded with a high-fidelity microma nometer. Results: The regional ϵ[subsys] and SR[subsys] were correlated with LV\i\/T in patients with HCM (r = 0.50, p<0.001 and r = 0.63, p<0.001, respectively) but not in patients with hypertensive LVH. The standard deviations of LVV\/T, ϵ[subsys] and SR[subsys] obtained from the eight LV segments of each subject were greater for patients with HCM than for patients with hypertensive LVH. The standard deviation of LVWT was correlated with those of ϵ[subsys] and SR[subsys] (r = 0.55, p<0.001 and r = 0.56, p<0.001, respectively). The standard deviations of LVVVT, ϵ[subsys] and SR[subsys] were correlated with tau )r = 0.35, p<0.05; r = 0.47, p<0.00l; and r = 0.39, p<0.005, respectively). Conclusions: Heterogeneity of regional LV systolic function detected by SR imaging is in part attributable to heterogeneity of LVH and may be linked to impaired global LV relaxation in HCM.


Related Articles

  • Echocardiography in patients with hypertrophic cardiomyopathy: usefulness of old and new techniques in the diagnosis and pathophysiological assessment. Losi, Maria-Angela; Nistri, Stefano; Galderisi, Maurizio; Betocchi, Sandro; Cecchi, Franco; Olivotto, Iacopo; Agricola, Eustachio; Ballo, Piercarlo; Buralli, Simona; D'Andrea, Antonello; D'Errico, Arcangelo; Mele, Donato; Sciomer, Susanna; Mondillo, Sergio // Cardiovascular Ultrasound;2010, Vol. 8, p7 

    Hypertrophic cardiomyopathy (HCM) is one of the most common inherited cardiomyopathy. The identification of patients with HCM is sometimes still a challenge. Moreover, the pathophysiology of the disease is complex because of left ventricular hyper-contractile state, diastolic dysfunction,...

  • Morphological and Electrical Characteristics in Patient with Hypertrophic Cardiomyopathy: Quantitative Analysis of 864 Korean Cohort. Sung-Hwan Kim; Yong-Seog Oh; Gi-Byoung Nam; Kee-Joon Choi; Dae Hee Kim; Jong-Min Song; Duk-Hyun Kang; Jae-Kwan Song; You-Ho Kim // Yonsei Medical Journal;Nov2015, Vol. 56 Issue 6, p1515 

    Purpose: Although several studies have reported the morphological and electrical characteristics in patients with hypertrophic cardiomyopathy (HCM), comparison between asymmetric and apical HCM has not been investigated in a reasonably sized cohort. Materials and Methods: Echocardiography and...

  • Sequential changes in myocardial function after valve replacement for aortic stenosis by speckle tracking echocardiography. Rost, Christian; Korder, S.; Wasmeier, G.; Wu, M.; Klinghammer, L.; Flachskampf, F. A.; Daniel, W. G.; Voigt, J.-U. // European Journal of Echocardiography;Aug2010, Vol. 11 Issue 7, p584 

    Aims: Regional myocardial function may change differently in different pathology. Speckle tracking echocardiography (STE) was applied to evaluate longitudinal, radial, and circumferential function in patients with aortic stenosis (AS) before, within 1 week, and 6 months after aortic valve...

  • Prevalence and clinical significance of systolic impairment in hypertrophic cardiomyopathy. Thaman, R.; Gimeno, J. R.; Murphy, R. T.; Kubo, T.; Sachdev, B.; Mogensen, J.; Elliott, P. M.; McKenna, W. J. // Heart;Jul2005, Vol. 91 Issue 7, p920 

    Objectives: To determine the frequency of systolic impairment (SI) and its impact on the natural history of hypertrophic cardiomyopathy (HCM). Methods: 1080 patients (mean (SD) age 43 (15) years, 660 men) with HCM were evaluated. Initial assessment included history, examination, 48 hour Holter...

  • Isolated Noncompaction of the Left Ventricular Myocardium. Gandhi, Ripal T.; Sarraf, Guilda; Budoff, Matthew // Texas Heart Institute Journal;2010, Vol. 37 Issue 3, p374 

    The article describes the case of a 52-year-old man who was diagnosed to have deep intertrabecular recesses in the noncompacted left ventricular myocardium. Initial echocardiography showed a left ventricular ejection fraction of 0.42. Images from a multidetector computed tomogram (MDCT) revealed...

  • Technological advances in tissue Doppler imaging echocardiography. Van de Veire, N. R.; De Sutter, J.; Bax, J. J.; Roelandt, J. R. T. C. // Heart;Aug2008, Vol. 94 Issue 8, p1065 

    Tissue Doppler imaging is a recently introduced echo-cardiographic tool for measuring myocardial velocities. In this article the physical principles and different myocardial velocity imaging modalities are discussed. Examples of practical applications and clinical use of this non-invasive...

  • The unravelling of primary myocardial impairment in Marfan syndrome by modern echocardiography. Kiotsekoglou, A.; Sutherland, G. R.; Moggridge, J. C.; Nassiri, D. K.; Camm, A. J.; Child, A. H. // Heart;Oct2009, Vol. 95 Issue 19, p14 

    Use of echocardiography has dramatically changed the way in which patients with Marfan syndrome are diagnosed, monitored and treated. Owing to the lethal nature of aortic complications, priority has been given to the assessment of the aortic root. Echocardiographic studies on patients with...

  • Contribution of ventricular assist devices to the recovery of failing hearts: a review and the Berlin Heart Center Experience. Dandel, Michael; Knosalla, Christoph; Hetzer, Roland // European Journal of Heart Failure;Mar2014, Vol. 16 Issue 3, p248 

    Ventricular assist-device ( VAD) implantation is a life-saving therapy which will later become either a bridge-to-transplantation or definitive therapy if heart transplantation ( HTx) is not possible. VAD-supported failing hearts often recover at the molecular and cellular level, but translation...

  • Application of Echocardiography on Transgenic Mice with Cardiomyopathies. G. Chen; Y. Li; J. Tian; L. Zhang; Jean-Charles, P.; Gobara, N.; C. Nan; J.-P. Jin; X. P. Huang // Biotechnology Research International;2012, p1 

    No abstract available.


Read the Article


Sign out of this library

Other Topics