TITLE

Increased Left Atrial Volume Index: Potent Biomarker for First-Ever Ischemic Stroke

AUTHOR(S)
Fatema, Kaniz; Bailey, Kent R.; Perry, George W.; Meissner, Irene; Osranek, Martin; Alsaileek, Ahmed A.; Khandheria, Buoy K.; Tsang, Teresa S.; Seward, James B.
PUB. DATE
October 2008
SOURCE
Mayo Clinic Proceedings;Oct2008, Vol. 83 Issue 10, p1107
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To establish the incidence and correlation of increased left atrial volume index (LAVI) in patients with first-ever lschemic stroke. PARTICIPANTS AND METHODS: Using our institution's epidemlological database, we defined a cohort of 432 patients (cases) who underwent transthoracic echocardiography within 60 days of first ischemic stroke between January 1, 1985, and December 31, 1994. Left atrial volume was measured with the biplane area-length method, indexed to body surface area (LAVI, expressed as mL/m². The control group consisted of 416 community residents who underwent transthoracic echocardiography as participants in a stroke risk factor study. Increased LAVI was defined as 28 mL/m² or higher. Survival In patients was compared with expected survival among white Minnesotans and was further modeled as a function of age, sex, LAVI, and clinical risk factors. RESULTS: Among the Included 306 patients, 230 (75%) had increased LAVI (mean ± SD, 49±21 mL/m²). Patients with Increased LAVI were older than those with normal LAVI (mean ± SD age, 76±11. vs 71±13 years; P=.003) and had more cardiovascular risk factors (mean ± SD number, 1.8±0.07 vs 1.3±0.89; P<.001). Mean LAVI was higher in cases than In age- and sex-matched controls (P<.001). At S-year follow-up, cases showed excess mortality compared with age-matched controls (P=.001). After variables were adjusted for age, sex, and clinical risk factors, LAVI was Independently associated with mortality. CONCLUSION: A useful Index for prediction of adverse cardiovascular events, LAVI might also predict first ischemic stroke and subsequent mortality.
ACCESSION #
34633271

 

Related Articles

  • Transient severe reversible functional mitral regurgitation: a three-dimensional transoesophageal perspective. Labbe, Vincent; Charlier, Patrick; Brochet, Eric; Iung, Bernard; Vahanian, Alec; Messika-Zeitoun, David // European Journal of Echocardiography;Apr2010, Vol. 11 Issue 3, pE3 

    Mrs B, a 49-year-old female, was referred to our institution for severe mitral regurgitation. Transthoracic echocardiography showed only a moderate organic mitral regurgitation, but a transient severe reversible functional mitral regurgitation was observed during transoesophageal...

  • Assessment of Mitral Regurgitation by the Measurement of Vena Contracta Using Power Doppler Echocardiography. Nozaki, Shiro; Mizushige, Katsufumi; Taminato, Tomohiko; Matsuo, Hirohide // International Journal of Angiology (Springer Science & Business ;Fall2003, Vol. 12 Issue 4, p234 

    The measurement of vena contracta is a promising method for quantification of mitral regurgitation (MR). No data exist regarding the ability of power Doppler echocardiography in the assessment of vena contracta in MR. We attempted to clarify the ability of power Doppler in the assessment of vena...

  • DIFFERENTIAL ECHOCARDIOGRAPHIC PATTERNS IN MITRAL REGURGITATION. Frankl, W. S.; MacMillan, R.; Smith, W. K. // Angiology;Dec1972, Vol. 23 Issue 11, p642 

    The syndrome of systolic click and late systolic murmur is due to ballooning or prolapse into the left atrium of one or both mitral valve leaflets during ventricular systole and with resulting mitral regurgitation and the characteristic murmur. The click results from sudden tensing of the...

  • Left atrial function and deformation in chronic primary mitral regurgitation. Borg, Alexander N.; Pearce, Keith A.; Williams, Simon G.; Ray, Simon G. // European Journal of Echocardiography;Oct2009, Vol. 10 Issue 7, p833 

    Aims: To study global and regional left atrial (LA) mechanics in chronic primary mitral regurgitation (MR) with echocardiography.

  • Using a double-plicated posterior leaflet as an anchor for mitral valve replacement: a case of mitral annular calcification. Taguchi, Shinichi; Niibori, Tatsuru; Hayashi, Ichiro; Kasahara, Hirofumi; Yozu, Ryohei // Journal of Cardiothoracic Surgery;2013, Vol. 8 Issue 1, Special section p1 

    We present a 62-year-old man with mitral regurgitation whose posterior annulus had severe calcification. Mitral valve replacement was performed by anchoring the cuff on a double-plicated posterior leaflet, and reinforcing with an equine pericardium. The patient is doing well 13 years after...

  • Fonksiyonel mitral yetersizliÄŸi. Sade, Leyla Elif // Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi;Jul2009 Supplement, Vol. 9, p3 

    Functional mitral regurgitation (FMR) is the mitral regurgitation that occurs due to myocardial disease in the presence of normal mitral valve leaflets. This scenario has the different characteristics than the organic mitral regurgitation. Functional mitral regurgitation is a disease of the...

  • Identification and quantification of prosthetic mitral regurgitation by flow convergence method using transthoracic approach. Arques, Stephane; Leonnet, Caroline; Roux, Emmanuel; Avierinos, Jean-François // Cardiovascular Ultrasound;2009, Vol. 7, Special section p1 

    The present case report illustrates the clinical applicability of the proximal isovelocity surface area (PISA) method in identifying, locating and assessing paravalvular prosthetic mitral regurgitation by transthoracic echocardiography.

  • Assessing prosthetic mitral valve regurgitation by transoesophageal echo/Doppler. Rahko, P. S. // Heart;May2004, Vol. 90 Issue 5, p476 

    Despite advances in imaging, the assessment of a mechanical prosthetic mitral valve remains a considerable challenge, particularly when valvar regurgitation is suspected. Transthoracic imaging is well suited to assess the haemodynamics of forward flow across prosthetic mitral valves. Thus...

  • Echocardiographic Confirmation of Mitral Valve Prolapse: A New Finding on Radionuclide Ventriculography -- A Case Report. Fig, Lorraine M.; Mountz, James M.; Gross, Milton D. // Angiology;Feb1989, Vol. 40 Issue 2, p138 

    A prominent filling defect was depicted on a radionucide ventriculogram in a patient with mitral regurgitation. This defect was later shown, by cardiac ultrasound, to he due to mitral valve prolapse into the left ventricle during diastole. This case illustrates that mitral valve prolapse should...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics