Old cells, new tricks
- Human embryonic stem cells: The future is now. Keller, Gordon; Snodgrass, H. Ralph // Nature Medicine;Feb99, Vol. 5 Issue 2, p151
The development of human embryonic stem cells as a research tool and therapeutic option offers a number of potential applications including the replacement of damaged tissues.
- Corrigendum: Quantifying cell-generated mechanical forces within living embryonic tissues. Campàs, Otger; Mammoto, Tadanori; Hasso, Sean; Sperling, Ralph A; O'Connell, Daniel; Bischof, Ashley G; Maas, Richard; Weitz, David A; Mahadevan, L; Ingber, Donald E // Nature Methods;Mar2014, Vol. 11 Issue 3, p349
A correction to the article related to quantifying cell-generated mechanical forces in living embryonic tissues is presented.
- Direct Reprogramming. Marbán, Eduardo; Cingolani, Eugenio // JAMA: Journal of the American Medical Association;7/7/2015, Vol. 314 Issue 1, p19
The authors comment on the direct reprogramming of stem cells for therapeutics. Topics covered include concerns that have restricted in vivo applications of tissues and organs to be recreated from embryonic stem cells, the limitations of induced stem cells as well as the complexity of...
- Blastocyst Brouhaha. Bailey, Ronald // Reason;Oct2001, Vol. 33 Issue 5, p25
Addresses the issues concerning embryonic stem cell research in the United States. Diseases which are potential for treatment by stem cells; Scientific explanation on how the stem cells may be of therapeutic use; Argument on the cloning issue related to the implementation of the research;...
- Rapid Development of Pluripotent Stem Cells as a Potential Therapeutic Modality. Williams, David A. // Molecular Therapy;Jun2009, Vol. 17 Issue 6, p929
The author reflects on the development of induced pluripotent stem (iPS) cells as potential tools for therapeutic applications. He discusses the importance of iPS and embryonic stem (ES) cells for biological studies and future therapies. He also examines several researches including the study...
- ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Kim, Myoung Ok; Kim, Sung-Hyun; Cho, Yong-Yeon; Nadas, Janos; Jeong, Chul-Ho; Yao, Ke; Kim, Dong Joon; Yu, Dong-Hoon; Keum, Young-Sam; Lee, Kun-Yeong; Huang, Zunnan; Bode, Ann M; Dong, Zigang // Nature Structural & Molecular Biology;Mar2012, Vol. 19 Issue 3, p283
Understanding and controlling the mechanism by which stem cells balance self-renewal versus differentiation is of great importance for stem cell therapeutics. Klf4 promotes the self-renewal of embryonic stem cells, but the precise mechanism regulating this role of Klf4 is unclear. We found that...
- THE STEM-CELL SAGA. // Popular Science;Mar2012, Vol. 280 Issue 3, p88
The article discusses the history of embryonic stem cell research, examining objections to stem-cell research by anti-abortion activists as well as the approval of a clinical trial of stem-cell therapy by the U.S. Food and Drug Administration.
- Therapeutic potential of human embryonic stem cell transplantation in patients with cerebral palsy. Shroff, Geeta; Gupta, Anupama; Barthakur, Jitender Kumar // Journal of Translational Medicine;2014, Vol. 12 Issue 1, p1
Background The present study evaluated the efficacy and safety of human embryonic stem cell (hESC) therapy in patients with CP. Materials and methods This analysis included patients (30 days-18 yr) with documented diagnosis of CP. The study consisted of four treatment phases (T1, T2, T3, T4)...
- Stem Cell Therapy for Diabetes: Are We Close Enough? Kadam, Sachin S. // Journal of Krishna Institute of Medical Sciences (JKIMSU);Jan-Jun2014, Vol. 3 Issue 1, p6
Over the last few decades, understanding of the mechanism of cellular development has increased tremendously. The knowledge of the potential of stem/precursor cells in tissue engineering and cell therapy has gained the popularity. In case of diabetes, the availability of the source of stem cells...