TITLE

Los felinos: ¿Una alternativa en estudios de toxicología genética?

AUTHOR(S)
Zamora-Perez, Ana; Gómez-Meda, Belinda C.; Ramos-Ibarra, María L.; Batista-González, Cecilia M.; Luna-Aguirre, Jaime; González-Rodríguez, Andrés; Rodríguez-Ávila, José L.; Zúñiga-González, Guillermo M.
PUB. DATE
June 2008
SOURCE
Revista de Biología Tropical;jun2008, Vol. 56 Issue 2, p969
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
The micronuclei (MN) test carry out in peripheral blood is fast, simple, economic and it is used to detect genotoxic environmental agents. MN are fragments of chromosomes or complete chromosomes remaining in the cytoplasm after cell division, which increase when organisms are exposed to genotoxic agents. Therefore, species with the highest values of spontaneous micronucleated erythrocytes (MNE) are the most suitable to be potentials biomonitor of micronucleogenic agents, using a drop of blood. Nine species of Felines that present spontaneous MNE in peripheral blood are shown. From these species, the cat has been previously proven, with positive results and also lion (Panthera leo), yaguaroundi (Felis yagoaroundi), lynx (Lynx ruffus), jaguar (Panthera onca), puma (Puma concolor), tiger (Panthera tigris), ocelote (Felis padalis) and leopard (Panthera pardus) display spontaneous MNE, and with this characteristic this Family can be propose like a potential group to be used in toxicogenetic studies.
ACCESSION #
34548414

 

Related Articles

  • EVALUATION OF THE GENOTOXICITY OF EURYCOMA LONGIFOLIA AQUEOUS EXTRACT (PHYSTA®) USING IN VITRO AMES TEST AND IN VIVO MAMMALIAN MICRONUCLEUS TEST. MING, YEE K.; ZULKAWI, NORAISYAH B. T.; CHOUDHARY, VANDANA K.; CHOUDHARY, YOGENDRA K. // International Journal of Pharmacy & Pharmaceutical Sciences;2014, Vol. 6 Issue 4, p652 

    Objective: In this study the genotoxic potential of Eurycoma longifolia aqueous extract (PHYSTA®) was investigated by the in vitro Ames test (Salmonella/microsome mutation assay) and the in vivo mouse peripheral blood cell micronucleus test. Eurycoma longifolia also known as Tongkat Ali in...

  • Hereditary spherocytosis with nephrotic syndrome. Mathew, A.; Varghese, J.; Kurian, G.; Unni, V. N. // Indian Journal of Nephrology;Oct-Dec2007, Vol. 17 Issue 4, p174 

    Hereditary spherocytosis is an autosomal dominant familial hemolytic disorder due to the abnormality of the erythrocyte membrane. We report a case of nephrotic syndrome due to membranoproliferative glomerulonephritis in a patient with hereditary spherocytosis.

  • THE EFFECT OF ENVIRONMENT ON PROLIFERATION AND MATURATION OF NUCLEATED RED CELLS. Erslev, Allan J. // Angiology;Jul1961, Vol. 12 Issue 7, p307 

    Examines the effect of the environment on the proliferation and maturation of nucleated red cells. Processes involved in sustained erythropoietic activity; Discussion on ways to prevent the pronormoblasts from being depleted during the process of cellular maturation; Probability of the red cells...

  • Extensive Ex Vivo Expansion of Functional Human Erythroid Precursors Established From Umbilical Cord Blood Cells by Defined Factors. Huang, Xiaosong; Shah, Siddharth; Wang, Jing; Ye, Zhaohui; Dowey, Sarah N; Tsang, Kit Man; Mendelsohn, Laurel G; Kato, Gregory J; Kickler, Thomas S; Cheng, Linzhao // Molecular Therapy;Feb2014, Vol. 22 Issue 2, p451 

    There is a constant shortage of red blood cells (RBCs) from sufficiently matched donors for patients who need chronic transfusion. Ex vivo expansion and maturation of human erythroid precursors (erythroblasts) from the patients or optimally matched donors could represent a potential solution....

  • Necrotising fasciitis. Mason, Philippa // British Journal of Perioperative Nursing;May2005, Vol. 15 Issue 5, p220 

    The article focuses on necrotising fasciitis which is a rare soft tissue infection, primarily involving the superficial fascia and resulting in extensive undermining of the surrounding tissues. Necrotising fasciitis usually occurs postoperatively after minor trauma or after inadequate care of...

  • REGULATION OF METHAEMOGLOBINAEMIA IN HORSE AND HUMAN ERYTHROCYTES. Robin, Helen; Harley, J. D. // Australian Journal of Experimental Biology & Medical Science;Feb1967, Vol. 45 Issue 1, p77 

    This article presents information regarding the regulation of methaemoglobinaemia in horse and human erythrocytes. Fresh, heparinised, venous blood was the source of erythrocytes. Horse erythrocytes were obtained from the jugular vein of apparently healthy, mature horses, normal human...

  • Induction of micronuclei in rat bone marrow after chronic exposure to lead acetate trihydrate. Alghazal, M. A.; Šutiaková, I.; Kovalkovicová, N.; Legáth, J.; Falis, M.; Pistl, J.; Sabo, R.; Benová, K.; Sabová, L.; Váczi, P. // Toxicology & Industrial Health;Oct2008, Vol. 24 Issue 9, p587 

    Lead increasingly contributes to pollution of the environment and may play a role in the development of adverse effects in the human and animal body. Data concerning its mutagenic, clastogenic, and carcinogenic properties have been conflicting. In this study, we evaluated the frequency of...

  • Molecular cloning and analysis of function of nucleoside diphosphate kinase (NDPK) from the scallop Chlamys farreri. Xiu-Zhen Shi; Xiao-Fan Zhao; Jin-Xing Wang // Biochemistry (00062979);Jun2008, Vol. 73 Issue 6, p686 

    Nucleoside diphosphate kinase (NDPK) is a key metabolic enzyme that catalyzes the synthesis of non-adenine nucleoside triphosphate (NTP) by transferring the terminal phosphate between nucleoside diphosphate (NDP) and NTP. NDPK regulates a variety of eukaryotic cellular activities including cell...

  • A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis. Imamura, Shintaro; Uchiyama, Junzo; Koshimizu, Eriko; Hanai, Jun-ichi; Raftopoulou, Christina; Murphey, Ryan D.; Bayliss, Peter E.; Imai, Yoichi; Burns, Caroline Erter; Masutomi, Kenkichi; Gagos, Sarantis; Zon, Leonard I.; Roberts, Thomas M.; Kishi, Shuji // PLoS ONE;2008, Vol. 3 Issue 10, p1 

    Although it is clear that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central function. To further examine the role of telomerase during vertebrate...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics