TITLE

Cirrhosis presenting as Parkinsonism

AUTHOR(S)
Noone, Mohan L.; Kumar, V. G. Pradeep; Ummer, K.; Achambat, Laila; Salam, K. A.
PUB. DATE
July 2008
SOURCE
Annals of Indian Academy of Neurology;Jul2008, Vol. 11 Issue 3, p179
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cirrhosis presenting as Parkinsonism is a distinct subset of acquired chronic hepatocerebral degeneration. The entity is not rare, and unless suspected, cirrhosis can easily be overlooked. We report our experience with three such patients. They presented to us, over a period of two years, with symmetrical Parkinsonism and were later diagnosed to have cirrhosis with portal hypertension. All patients had minimal or absent tremors. Reversal of serum albumin to globulin ratio and evidence of cirrhosis on abdominal ultrasound were consistent. All three patients had the characteristic MRI abnormality of symmetrical T1 hyperintensity in basal ganglia and anterior midbrain. They improved to variable extents after treatment for cirrhosis, along with dopa agonists. We stress the importance of recognizing this syndrome and briefly review the relevant literature.
ACCESSION #
34487121

 

Related Articles

  • Neinvazivna procena postojanja i veličine variksa jednjaka kod bolesnika obolelih od ciroze jetre pomoću indeksa desni lobus jetre/serumska koncentracija albumina. Alempijević, Tamara; Bulat, Vladislava; Kovačević, Nada; Ješić, Rada; Đuranović, Srđan; Tomić, Dragan; Krstić, Miodrag // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Jul2007, Vol. 64 Issue 7, p453 

    Background/Aim. Liver cirrhosis is a chronic, progressive disease and it is usually accompanied by portal hypertension. The development of oesophageal varices (OV) is one of the major complications of portal hypertension. Cirrhotic patients should be screened for the presence of OV when portal...

  • Acute propranolol administration effectively decreases portal pressure in patients with TIPS dysfunction. Bellis, L.; Moitinho, E.; Abraldes, J.G.; Graupera, M.; García-Pagán, J.C.; Rodés, J.; Bosch, J. // Gut;Jan2003, Vol. 52 Issue 1, p130 

    Background and aims: Up to 60% of patients treated with transjugular intrahepatic portosystemic shunt (TIPS) require angioplasty or restenting during the first year of follow up because of TIPS dysfunction (stenosis of the intrahepatic shunt increasing the portal pressure gradient above the 12...

  • Transjugular intrahepatic portosystemic shunt: Efficacy... Cosenza, Carlos A.; Hoffman, Allen L. // American Surgeon;Oct1996, Vol. 62 Issue 10, p835 

    Presents a study which dealt with the authors' experience with transjugular intrahepatic portosystemic shunts (TIPS) in patients with portal hypertension. Effect of procedure on patients who subsequently underwent orthotopic liver transplantation (OLT); Materials and methods used in study;...

  • Grading portal gastropathy: validation of a gastropathy scoring system. Stewart, Charmaine A.; Sanyal, Arun J. // American Journal of Gastroenterology;Aug2003, Vol. 98 Issue 8, p1758 

    : ObjectiveThe specific aim of this study was to independently evaluate the reproducibility and validity of the Baveno portal hypertensive gastropathy (PHG) grading system.: MethodsThis is a prospective study of 100 consecutive patients with cirrhosis and portal gastropathy. An endoscopy was...

  • Serum-Ascites Albumin Difference in Tuberculous Peritonitis. Marshall, John B.; Vogele, Kenneth A. // American Journal of Gastroenterology;Nov1988, Vol. 83 Issue 11, p1259 

    Recent studies have shown that the serum-ascites albumin difference provides better diagnostic discrimination than the ascites total protein concentration in the separation of "transudative" (portal hypertension) ascites and "exudative" (non-portal hypertension) ascites. Published studies to...

  • plasma protein fraction.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1801 

    A definition of the term "plasma protein fraction," which refers to a standard preparation of serum albumin and globulin, is presented.

  • Upright posture blunts postprandial splanchnic hyperemia in patients with cirrhosis and portal hypertension. Iwao, Tadashi; Oho, Kazuhiko; Nakano, Ryohichi; Yamawaki, Makoto; Sakai, Teruhiro; Sato, Masahiro; Miyamoto, Yasunao; Sakai, Kenji; Sata, Michio; Toyonaga, Atsushi // Journal of Gastroenterology;1999, Vol. 34 Issue 3, p359 

    Abstract: The aim of this study was to compare postprandial hemodynamic changes observed during assumption of the recumbent posture and upright posture in patients with cirrhosis and portal hypertension. Eleven patients with cirrhosis and portal hypertension were studied. Echo-Doppler...

  • Does portal hypertension contribute to the pathogenesis of gastric ulcer associated with liver cirrhosis? Kitano, Seigo; Dolgor, Baatar // Journal of Gastroenterology;2000, Vol. 35 Issue 2, p79 

    Examines the role of portal hypertension in the pathogenesis of gastric ulcer associated with liver cirrhosis. Prevalence of gastric ulcer in cirrhosis; Factors involved in the pathogenesis of gastric ulcer in liver cirrhosis; Information on gastric ulcer healing.

  • Propranolol Compared with Proparnolol plus Isosorbide-5-Mononitrate for Portal Hypertension in Cirrhosis. Garcia-Pagan, Joan Carles; Feu, Faust; Bosch, Jaume; Rodes, Joan // Annals of Internal Medicine;5/15/91, Vol. 114 Issue 10, p869 

    Investigates whether isosorbide-5-mononitrate (Is-5-Mn) given with propranolol reduces hepatic portal pressure more than propranolol alone in patients with cirrhosis. Common use of propranolol; Mechanism by which combined therapy enhances the reduction in the hepatic venous pressure gradient.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics