Improving head growth in preterm infants — a randomised controlled trial II: MRI and developmental outcomes in the first year

Tan, M.; Abernethy, L.; Cooke, R.
September 2008
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Sep2008, Vol. 93 Issue 5, pF342
Academic Journal
Background: Very preterm infants are at risk of poor growth and neurodevelopmental outcome. Illness and difficulties overcoming the challenges of feeding these infants often lead to undernutrition in the first few weeks. Objective: To explore the relationships between early nutrition, post-natal head growth, quantitative magnetic resonance imaging (MRI) and developmental outcome in the first year among infants born before 29 weeks' gestation. Design: Infants born before 29 weeks' gestation were randomised to receive hyperalimented or standard feeding regimen from birth to 34 weeks' postmenstrual age (PMA). The primary outcome was occipitofrontal circumference (OFC) at 36 weeks' OFC. Quantitative MRI was performed at 40 weeks' PMA. Developmental assessment using Bayley Scales of Infant Development II (BSID II) was carried out at 3 and 9 months post-term. Results: 1 D9 infants survived to the end of the first year PMA. 65 infants underwent MRI scan. 81 and 71 infants were seen at 3 and 9 months post-term. Quantitative MRI findings, mental development index (MDI) and psychomotor development index IPDII were not statistically different between the two groups. Total brain volume (TBV) at 40 weeks' PMA, MDI and PDI at 3 months post-term correlated significantly with energy deficit at 28 days of age. Conclusions: Improving early energy deficit in very preterm infants may promote brain growth. Quantitative MRI may have a role to play in predicting developmental outcome. Post-natal growth at 36 weeks' PMA and quantitative MRI finding at 40 weeks' PMA appear to be closely related to mental outcomes in the first year. Trial registration number: ISRCTN 19509258


Related Articles

  • Improving head growth in very preterm infants — a randomised controlled trial I: neonatal outcomes. Tan, M. J.; Cooke, R. W. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Sep2008, Vol. 93 Issue 5, pF337 

    Background: Infants born very preterm are at an increased risk of poor growth in the post-natal period. Poor brain growth in this critical period may result from inadequate nutrition, and has long-term effects on neurodevelopmental outcome. Aims: To examine the feasibility of providing...

  • Parenchymal Brain Injury in the Preterm Infant: Comparison of Cranial Ultrasound, MRI and Neurodevelopmental Outcome. Lampe, John B.; Chandra, Sudhish; Spitzer, Alan R. // Clinical Pediatrics;Apr2002, Vol. 41 Issue 3, p191 

    Comments on a study which compared the effectiveness of magnetic resonance imaging with cranial ultrasound in predicting neurodevelopmental outcome in preterm infants. Data used in the study; Results of the study.

  • Data quality in diffusion tensor imaging studies of the preterm brain: a systematic review. Pieterman, Kay; Plaisier, Annemarie; Govaert, Paul; Leemans, Alexander; Lequin, Maarten; Dudink, Jeroen // Pediatric Radiology;Aug2015, Vol. 45 Issue 9, p1372 

    Background: To study early neurodevelopment in preterm infants, evaluation of brain maturation and injury is increasingly performed using diffusion tensor imaging, for which the reliability of underlying data is paramount. Objective: To review the literature to evaluate acquisition and...

  • Prognostic value of gradient echo T2* sequences for brain MR imaging in preterm infants. Bruïne, Francisca; Steggerda, Sylke; Berg-Huysmans, Annette; Leijser, Lara; Rijken, Monique; Buchem, Mark; Wezel-Meijler, Gerda; Grond, Jeroen // Pediatric Radiology;Mar2014, Vol. 44 Issue 3, p305 

    Background: Gradient echo T2*-W sequences are more sensitive than T2-W spin-echo sequences for detecting hemorrhages in the brain. Objective: The aim of this study is to correlate presence of hemosiderin deposits in the brain of very preterm infants (gestational age <32 weeks) detected by T2*-W...

  • Stereological evaluation of the volume and volume fraction of newborns' brain compartment and brain in magnetic resonance images. Nisari, Mehtap; Ertekin, Tolga; Özçelik, Özlem; Çınar, Şerife; Doğanay, Selim; Acer, Niyazi // Surgical & Radiologic Anatomy;Nov2012, Vol. 34 Issue 9, p825 

    Purpose: Brain development in early life is thought to be critical period in neurodevelopmental disorder. Knowledge relating to this period is currently quite limited. This study aimed to evaluate the volume relation of total brain (TB), cerebrum, cerebellum and bulbus+pons by the use of...

  • Body growth and brain development in premature babies: an MRI study. Tzarouchi, Loukia; Drougia, Aikaterini; Zikou, Anastasia; Kosta, Paraskevi; Astrakas, Loukas; Andronikou, Styliani; Argyropoulou, Maria // Pediatric Radiology;Mar2014, Vol. 44 Issue 3, p297 

    Background: Prematurity and intrauterine growth restriction are associated with neurodevelopmental disabilities. Objective: To assess the relationship between growth status and regional brain volume (rBV) and white matter microstructure in premature babies at around term-equivalent age....

  • Retraction notice.  // Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2014, Vol. 99 Issue 3, pF252 

    A retraction to the article "NIDCAP in preterm infants and the neurodevelopmental effect in the first 2 years" by L. Fazilleau and colleagues that was published online on October 31, 2013 is presented.

  • The Prediction of Later Neurodevelopmental Status of Preterm Infants at Ages 7 to 10 Years Using the Bayley Infant Neurodevelopmental Screener. Soysal, A. Sebnem; Gucuyener, Kivilcim; Ergenekon, Ebru; Turan, Özden; Koc, Esin; Turkyılmaz, Canan; Önal, Esra; Atalay, Yıldız // Journal of Child Neurology;Oct2014, Vol. 29 Issue 10, p1349 

    The aim of this study was to see whether the scores of the Bayley Infant Neurodevelopmental Screener of 45 high-risk preterm infants (gestational age 26-37 wk) between the ages of 3 and 24 months predicted neurodevelopmental status at 7 to 10 years of age. Neurodevelopmental status of 45/122...

  • Visual function in preterm infants: visualizing the brain to improve prognosis. Chau, Vann; Taylor, Margot; Miller, Steven // Documenta Ophthalmologica;Aug2013, Vol. 127 Issue 1, p41 

    Considerable development of the visual system occurs in the third trimester of life, a time when very preterm-born infants are in a neonatal intensive care unit (NICU). Their very early birth during a period of rapid and marked neurodevelopment and their clinical course makes them a very...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics