Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors

Icoz, Kutay; Iverson, Brian D.; Savran, Cagri
September 2008
Applied Physics Letters;9/8/2008, Vol. 93 Issue 10, p103902
Academic Journal
We report noise and detection limitations in cantilever-based immunomagnetic biosensors. A differential cantilever system with sensing and control arms was used whereby the control arm was passivated with bovine serum albumin (BSA) and the sensing arm was functionalized with biotin-BSA. Streptavidin-coated magnetic beads were exposed to cantilever arms. An oscillatory magnetic field induced a magnetic force on the beads which caused a relative deflection of the sensing arm. Increasing the excitation frequency suppressed the 1/f noise by 100-fold, resulting in a deflection resolution of 0.065 Ã… in air.


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