TITLE

Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA

AUTHOR(S)
Li-Ping Bai; Zongwei Cai; Zhong-Zhen Zhao; Nakatani, Kazuhiko; Zhi-Hong Jiang
PUB. DATE
October 2008
SOURCE
Analytical & Bioanalytical Chemistry;Oct2008, Vol. 392 Issue 4, p709
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Spectrofluorometric titration, electrospray ionization time-of-flight mass spectrometric and UV melting methods were employed to study the binding of chelerythrine and sanguinarine to bulged DNA. The results showed that both alkaloids bind specifically to single pyrimidine (C, T) bulge sites. The ability of sanguinarine to bind to both regular and bulged hairpins was found to be stronger than that of chelerythrine, but the binding selectivity of chelerythrine toward single-base bulges was much larger than that of sanguinarine. [Figure not available: see fulltext.]
ACCESSION #
34426256

 

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