Airway epithelial gene expression to detect lung cancer in smokers

Nanguzgambo, A. B.
September 2008
Thorax;Sep2008, Vol. 63 Issue 9, p774
Academic Journal
The article discusses a research which cites that gene expression in normal large airway epithelial cells can be used as a lung cancer biomarker and improve the diagnostic sensivity of bronchoscopy by supplementing the current cytopathological methods. Where facilities become availabel for performing such gene biomarker testing, further invasive testing may be avoided.


Related Articles

  • Gene Expression Tests Using Bronchial, Nasal Epithelium Under Development for Early Detection of Lung Cancer. Spira, Avrum // Personalized Medicine in Oncology;Nov2013, Vol. 2 Issue 7, p375 

    Information on the link between nasal and bronchial gene expression changes which may make nasal changes detect early lung cancer discussed at the 2013 Global Biomarkers Consortium conference is presented. The challenge is how to identify the 10% to 50% of smokers who will develop the disease in...

  • P130cas is required for TGF-β1-mediated epithelial-mesenchymal transition in lung cancer. BO DENG; QUN-YOU TAN; RU-WEN WANG; YAO-GUANG JIANG; JING-HAI ZHOU; WEI HUANG // Oncology Letters;2014, Vol. 8 Issue 1, p454 

    In lung cancer A549 cells, the present study evaluated the associations between p130cas expression and the activation of p38 or Smad2, which are components of two of the main signaling pathways of transforming growth factor-β1 (TGF-β1), i.e., epithelial-mesenchymal transition (EMT) and...

  • Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Spira, Avrum; Beane, Jennifer E; Shah, Vishal; Steiling, Katrina; Liu, Gang; Schembri, Frank; Gilman, Sean; Dumas, Yves-Martine; Calner, Paul; Sebastiani, Paola; Sridhar, Sriram; Beamis, John; Lamb, Carla; Anderson, Timothy; Gerry, Norman; Keane, Joseph; Lenburg, Marc E; Brody, Jerome S // Nature Medicine;Mar2007, Vol. 13 Issue 3, p361 

    Lung cancer is the leading cause of death from cancer in the US and the world. The high mortality rate (80–85% within 5 years) results, in part, from a lack of effective tools to diagnose the disease at an early stage. Given that cigarette smoke creates a field of injury throughout the...

  • Genetic Variation and Antioxidant Response Gene Expression in the Bronchial Airway Epithelium of Smokers at Risk for Lung Cancer. Xuting Wang; Chorley, Brian N.; Pittman, Gary S.; Kleeberger, Steven R.; Brothers II, John; Gang Liu; Spira, Avrum; Bell, Douglas A. // PLoS ONE;2010, Vol. 5 Issue 8, p1 

    Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell gene expression response to smoking can serve as an early diagnostic biomarker for lung cancer. As a first step in applying functional genomic analysis to...

  • MicroRNA-570-3p regulates HuR and cytokine expression in airway epithelial cells. Roff, Alanna N.; Craig, Timothy J.; August, Avery; Stellato, Cristiana; Ishmael, Faoud T. // American Journal of Clinical & Experimental Immunology;2014, Vol. 3 Issue 2, p68 

    Asthma is a chronic lung disease that affects people of all ages and is characterized by high morbidity. The mechanisms of asthma pathogenesis are unclear, and there is a need for development of diagnostic biomarkers and greater understanding of regulation of inflammatory responses in the lung....

  • Changes in Gene Expression and Cellular Architecture in an Ovarian Cancer Progression Model. Creekmore, Amy L.; Silkworth, William T.; Cimini, Daniela; Jensen, Roderick V.; Roberts, Paul C.; Schmelz, Eva M. // PLoS ONE;2011, Vol. 6 Issue 3, p1 

    Background: Ovarian cancer is the fifth leading cause of cancer deaths among women. Early stage disease often remains undetected due the lack of symptoms and reliable biomarkers. The identification of early genetic changes could provide insights into novel signaling pathways that may be...

  • Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk. Wang, Xuting; Pittman, Gary; Bandele, Omari; Bischof, Jason; Liu, Gang; Brothers, John; Spira, Avrum; Bell, Douglas // Human Genetics;Dec2014, Vol. 133 Issue 12, p1467 

    Chronic cigarette smoking exposes airway epithelial cells to thousands of carcinogens, oxidants and DNA-damaging agents, creating a field of molecular injury in the airway and altering gene expression. Studies of cytologically normal bronchial epithelial cells from smokers have identified...

  • Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung Cancer. Bo Zhang; Chengchu Zhu; Baofu Chen; Xia Zhang; Minhua Ye; Aifen Lin // Chinese Journal of Lung Cancer;Dec2010, Vol. 13 Issue 12, p1132 

    Background and objective Precious studies proven that the overexpression of eukaryotic translation initiation factor 4E (eIF4E) in a variety of solid tumors has linked with malignant tumorigenesis, invasion and metastasis. The aim of this work is to explore the expression of eIF4E and its...

  • Expressions of Cyr61 and WISP-3 in Non-small Cell Lung Cancer and Its Clinical Significance. Jianfa Lv; Youcheng Zou; Chunwei Zhang; Zhifu Mao // Chinese Journal of Lung Cancer;Dec2010, Vol. 13 Issue 12, p1122 

    Background and objective Cysteine-rich protein 61 (Cyr61) plays a role as a tumor suppressor in non-small cell lung cancer (NSCLC). Cyr61 and WISP-3 have a very significant sequence homology, belonging to the same CCN gene family. The aim of this study is to investigate the expressions of Cyr61...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics