TITLE

Automated immunochemical quantitation of haemoglobin in faeces collected on cards for screening for colorectal cancer

AUTHOR(S)
Fraser, C. G.; Mathew, C.. M.; McKay, K.; Carey, F. A.; Steele, R. J. C.
PUB. DATE
September 2008
SOURCE
Gut;Sep2008, Vol. 57 Issue 9, p1256
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Simple card collection systems are becoming available for faecal immunochemical tests (FITs) as well as guaiac faecal occult blood tests (gFOBTs). FITs are now obtainable that allow quantitation of haemoglobin, so that the analytical detection limit can be set to give a positivity rate that is manageable in terms of the available colonoscopy. A combination of a card collection device and an automated FIT analytical system could be advantageous. Methods: The quantitation of haemoglobin in samples collected on cards with a new analytical system and the relationship between faecal haemoglobin concentration and pathology were investigated in a cohort of gFOBT- positive individuals. Results: All groups had large ranges of haemoglobin concentration and there was overlap between the groups. Median haemoglobin concentrations in participants with normal findings on colonoscopy 1167) diverticular disease 143), hyperplastic polyps (41), low risk adenoma (63), higher risk adenoma (35) and cancer (27) were 13.5, 15.6, 16.8, 15.2, 65.6 and 168.9 ng/ml haemoglobin, respectively. Those with diverticular disease, hyperplastic polyps and low risk adenoma were not significantly different from the normal group (p>0.2), but those with higher risk adenoma had significantly higher concentrations (p<0.001), as did those with cancer (p<0.001). Receiver operating characteristic analysis demonstrates that the cut-off concentration can be set to give appropriate clinical characteristics; optimum sensitivity and specificity are achieved at 26.7 ng/ml. Conclusions: The haemoglobin in faeces on simple FIT card collection devices can be immunoturbidimetrically analysed quantitatively, and the concentration relates to the presence or absence of significant neoplastic disease.
ACCESSION #
34310413

 

Related Articles

  • RECTAL ABERRANT CRYPT FOCI IDENTIFIED USING HIGH-MAGNIFICATION-CHROMOSCOPIC COLONOSCOPY: BIOMARKERS FOR RIGHT-HEMICOLONIC FLAT AND DEPRESSED NEOPLASIA. Hurlstone, D. P.; Cross, S. S.; Shorthouse, A. J.; Brown, S.; Adam, I.; Lobo, A. J. // Gut;Apr2004 Supplement 3, Vol. 53, pA9 

    Aberrant crypt foci (ACF) may represent pre-neoplastic lesions in the human colon. The prevalence of ACF detected using magnification chromoscopic colonoscopy is known to follow a stepwise progression from normal subjects to those with exophytic adenomas and colon cancer (CC). No studies have...

  • Do distal adenomas mandate total colonoscopy? Khan, A.; Shrier, I.; Gordon, P.H. // Surgical Endoscopy;Jun2003, Vol. 17 Issue 6, p886 

    Background: Distal adenomas have been considered markers of proximal neoplasms. It also has been suggested that patients with small, distal adenomas do not require proximal examination of the colon. This study was conducted to determine the validity of the latter recommendation. Methods: From a...

  • Narrow band imaging for colonoscopic surveillance in hereditary non-polyposis colorectal cancer. East, J. E.; Suzuki, N.; Stavrinidis, M.; Guenther, I.; Thomas, H. J. W.; Saunders, B. P. // Gut;Jan2008, Vol. 57 Issue 1, p65 

    Background: Colonoscopic surveillance for hereditary non-polyposis colorectal cancer (HNPCC) reduces death rates, but early interval cancers still occur, probably due to missed small, aggressive adenomas. Narrow band imaging (NBI), a novel endoscopic technology, highlights superficial mucosal...

  • Indigocarmine added to the water exchange method enhances adenoma detection - a RCT. Leung, Joseph; Mann, Surinder; Siao-Salera, Rodelei; Ngo, Catherine; McCreery, Randy; Canete, Wilhemina; Leung, Felix // Journal of Interventional Gastroenterology;7/ 1/2012, Vol. 2 Issue 3, p106 

    Purpose: Chromoendoscopy with dye spray and the water method both increase adenoma detection. Hypothesis: Adding indigocarmine to the water method will enhance further the effectiveness of the latter in adenoma detection. Methods: Screening colonoscopy was performed with the water method...

  • Endoscopists with low adenoma detection rates benefit from high-definition endoscopy. Waldmann, Elisabeth; Britto-Arias, Martha; Gessl, Irina; Heinze, Georg; Salzl, Petra; Sallinger, Daniela; Trauner, Michael; Weiss, Werner; Ferlitsch, Arnulf; Ferlitsch, Monika // Surgical Endoscopy;Feb2015, Vol. 29 Issue 2, p466 

    Background: An endoscopists adenoma detection rate (ADR) of less than 20 % correlates with high risk for occurrence of interval cancer. The impact of high-definition (HD) imaging on the ADR is discussed controversially. We aimed to investigate whether detection rates of individual endoscopists...

  • Colorectal Neoplasms and Barrett's Esophagus. Tripp, Michael R.; Sampliner, Richard E.; Kogan, Frederick J.; Morgan, Timothy R. // American Journal of Gastroenterology;Nov1986, Vol. 81 Issue 11, p1063 

    Prospective colonoscopic study of 36 patients with Barrett's esophagus found colorectal adenomas in 33% of patients. Of patients aged less than 60, four of 17 (24%) had adenomas, while patients aged 60 or more had adenomas in eight of 19 (42%) cases. All adenomas were ≤10 mm diameter. No...

  • Prevalence of Colonic Neoplasia in Patients with Barrett's Esophagus. Post, Anthony B.; Achkar, Edgar; Carey, William D. // American Journal of Gastroenterology;Jun1993, Vol. 88 Issue 6, p877 

    Recent reports have suggested that there might be an increased risk of colonic adenomas and cancer in patients with Barrett's esophagus. We conducted a controlled prospective study investigating the risk of colonic neoplasia in 17 patients with Barrett's esophagus. Six additional patients with...

  • Characteristics of Rectosigmoid Adenomas as Predictors of Synchronous Advanced Proximal Colon Neoplasms. Papatheodoridis, George V.; Triantafyllou, Konstantinos; Tzouvala, Maria; Paspatis, Gregorios; Xourgias, Vassilios; Karamanolis, Demetrios G. // American Journal of Gastroenterology;Sep1996, Vol. 91 Issue 9, p1809 

    Background/Aim: Colonoscopy is recommended to every patient with adenoma in rectosigmoid to disclose synchronous proximal neoplasms. The aim of this study was to determine whether characteristics of rectosigmoid adenomas are associated with proximal advanced neoplasms. Patients/Methods: One...

  • Sporadic duodenal adenoma is associated with colorectal neoplasia. Murray, M. A.; Zimmerman, M. J.; Ee, H. C. // Gut;Feb2004, Vol. 53 Issue 2, p261 

    Objective: The objective of this study was to assess the association between colorectal neoplasia and sporadic duodenal adenoma. Methods: A retrospective case control study was conducted using the databases of two major teaching hospitals in Western Australia. The frequency of colorectal...

  • A prospective randomised study on narrow-band imaging versus conventional colonoscopy for adenoma detection: does narrow-band imaging induce a learning effect? Adler, A.; Pohl, H.; Papanikolaou, I. S.; Abou-Rebyeh, H.; Schachschal, G.; Veltzke- Schlieker, W.; Khalifa, A. C.; Setka, E.; Koch, M.; Wiedenmann, B.; Rösch, T. // Gut;Jan2008, Vol. 57 Issue 1, p59 

    Background and aims: Colonoscopy is an established method of colorectal cancer screening, but has an adenoma miss rate of 10-20%. Detection rates are expected to improve with optimised visualisation methods. This prospective randomised study evaluated narrow-band imaging (NBI), a new technique...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics