Characteristics of HCN Channels and Their Participation in Neuropathic Pain

Yu-Qiu Jiang; Qian Sun; Hui-Yin Tu; You Wan
October 2008
Neurochemical Research;Oct2008, Vol. 33 Issue 10, p1979
Academic Journal
Abstract  Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain. The underlying mechanisms include peripheral and central sensitization resulted from neuronal hyperexcitability. A number of ion channels are considered to contribute to the neuronal hyperexcitability. Here, we particularly concentrate on an interesting ion channel, hyperpolarization-activated cyclic nucleotide gated (HCN) channels. We overview its biophysical properties, physiological functions, followed by focusing on the current progress in the study of its role in the development of neuropathic pain. We attempt to provide a comprehensive review of the potential valuable target, HCN channels, in the treatment of neuropathic pain.


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