TITLE

Chronic, but Not Acute Morphine Treatment, Up-regulates α-Ca2/calmodulin Dependent Protein Kinase II Gene Expression in Rat Brain

AUTHOR(S)
Yuejun Chen; Yan Jiang; Wen Yue; Yuqing Zhou; Lin Lu; Lan Ma
PUB. DATE
October 2008
SOURCE
Neurochemical Research;Oct2008, Vol. 33 Issue 10, p2092
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  The effects of acute and chronic morphine treatments on the expression of Ca2ﷆꖚ蝮阩 dependent protein kinase II (CaMK II) gene in rat brain were investigated using in situ hybridization histochemistry. Our data showed that repeated, but not single morphine administration, resulted in significant up-regulation of the α-CaMK II gene expression in hippocampus and frontal cortex. We further studied the time courses of α-CaMK II gene expression in response to repeated morphine administration. After 3 days of consecutive morphine injections, the α-CaMK II mRNA levels exhibited a trend of up-regulation, and after 6 days of consecutive morphine injections it increased over 50–60% as compared with the control group. The α-CaMK II mRNA levels remained high 24 h after the cessation of chronic morphine treatment and returned to the control level 72 h later. However, changes of α-CaMK II gene levels mentioned above were not detected in amygdala or piriform cortex. Taken together, our data demonstrate that chronic morphine treatment region-specific up-regulates the levels of the α-CaMK II gene expression in hippocampus and frontal cortex.
ACCESSION #
34305431

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics